A5081436508- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Cerebral Venous Sinus Thrombosis
- Ocular Oncology and Treatments
- Systemic Lupus Erythematosus Research
- Natural Products and Biological Research
- Head and Neck Surgical Oncology
- Molecular Junctions and Nanostructures
- Economic and Environmental Valuation
- Drug-Induced Ocular Toxicity
- Consumer Behavior in Brand Consumption and Identification
- Decision-Making and Behavioral Economics
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Biotin and Related Studies
- Glycosylation and Glycoproteins Research
- Corneal Surgery and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Behavioral Health and Interventions
- Consumer Retail Behavior Studies
Seoul National University Bundang Hospital
2018-2024
Konkuk University
2024
National University College
2023-2024
New Generation University College
2024
Seoul National University Hospital
2015-2023
University of the East Ramon Magsaysay Memorial Medical Center
2023
Woosuk University
2020
Neami National
2020
Seoul National University
2017
Baruch College
2006
<h3>Importance</h3> Retinal layer thickness is hypothesized to be related cognitive function in patients with mild impairment (MCI) and Alzheimer disease (AD). However, longitudinal cohort studies of the healthy older population are scarce. <h3>Objective</h3> To investigate association between retinal future decline a community-based cohort. <h3>Design, Setting, Participants</h3> A total 430 randomly sampled community-dwelling Korean individuals 60 years or participated baseline assessment...
To explore the relationship between immunogenicity and intraocular inflammation in intravitreal anti-VEGF drugs Perspective This review examines of individual their potential link to inflammation. We suggest that main cause is presence pre-existing treatment-induced anti-drug antibodies, along with considerations related molecular structure, which includes drug's format size. Researchers clinicians involved advancement new should take into consideration factors have been discussed.
Purpose: To investigate the intraocular distribution and kinetics of antibodies nanoparticles in experimental model. Methods: Antibodies (whole IgG 149kDa, antigen-binding fragments 48.39 kDa) four kinds nondegradable (25, 50, 200, 250 nm) were intravitreally injected right eye New Zealand white rabbits. The average optical density concentration used to measure kinetics. Results: After intravitreal injection, distributed throughout vitreous humor eliminated gradually into anterior posterior...
To objectively assess pupillary involvement according to various etiologies of acquired isolated third nerve palsy using automated pupillometry, and evaluate the efficacy digital pupillometry in discriminating compressive lesions from microvascular ischemic palsy.Retrospective, observational case series.A total 171 subjects were included this study, consisting 60 with presumed palsy, 51 non-ischemic controls whose light responses measured a dynamic pupillometer. Subjects divided into...
Objectives To investigate the characteristics and temporal changes in visual field defects (VFDs) eyes with acute central retinal artery occlusion (CRAO). Design Retrospective, observational case series Methods A total of 119 patients diagnosed non-arteritic CRAO through examination Goldmann perimetry were included among who visited Seoul National University Bundang Hospital between January 2009 December 2016. They treated either conservative treatments or intra-arterial thrombolysis (IAT)....
<b><i>Purpose:</i></b> This study was aimed at determining the intraocular pharmacokinetics based on molecular physicochemical properties in a rabbit model. <b><i>Methods:</i></b> The entire dataset obtained from previous literature, and research articles regarding 70 compounds were investigated. intravitreal half-lives eyeballs of 22 macromolecules 48 micromolecules analyzed. Multiple linear regression analysis carried out with non-collinear...
Purpose: To investigate intraocular pharmacokinetics of 10-fold dose intravitreally injected ranibizumab compared with the conventional in an experimental model. Methods: Ranibizumab 30 µL at 10 mg/mL (conventional) and 100 (10-fold) doses was separately into each eye 28 rabbits. concentrations aqueous humor, vitreous, retina were estimated time period after injection, using enzyme-linked immunosorbent assay. The pharmacokinetic properties determined a one-compartment model all three ocular...
In this study, Retina-RPE-Choroid-Sclera (RCS) and RPE-Choroid-Sclera (CS) were prepared by scraping them off neural retina, using the Ussing chamber we measured average time–concentration values in acceptor across five isolated rabbit tissues for each drug molecule. We determined outward direction permeability of RCS CS calculated retina permeability. The coefficients as follows: ganciclovir, 13.78 ± 5.82 23.22 9.74; brimonidine, 15.34 7.64 31.56 12.46; bevacizumab, 0.0136 0.0059 0.0612...
The etiology of central retinal artery occlusion (CRAO) is unclear in approximately 50% patients, suggesting pathomechanical heterogeneity; moreover, little known about outcomes according to etiology. This study investigated whether the presence an embolic source affects outcome CRAO.CRAO patients within 7 days symptom onset were retrospectively enrolled. Clinical parameters, including initial and 1-month visual acuity, CRAO subtype, brain images, reviewed. was categorized as with or without...
To evaluate the long-term visual outcomes and complications of cataract surgery in eyes previously treated for retinoblastoma.We reviewed medical records patients who underwent extraction intraocular lens implantation at Seoul National University Children's Hospital a secondary that developed after retinoblastoma treatment.During period between 1990 2014, 208 147 received eye-salvaging treatment (radiotherapy, chemotherapy, local therapy) Hospital. Among these eyes, was detected 17 14...
Abstract We investigated the full-field electroretinographic (ERG) parameters with visual function and prognosis in central retinal artery occlusion (CRAO), according to its severity. 110 affected eyes of CRAO patients were enrolled compared fellow uninvolved (N = 110) normal control 30). B/A ratio photopic negative response amplitude (PhNR) resulted statistically significant differences among subgroups severity ischemia. Amplitudes PhNR indicating ganglion cell showed a more marked decline...
Vitreoretinal lymphoma is a malignancy with high mortality. Incidence rare, and there lack of medical evidence to direct management. This work describes presentation, diagnostic testing, first treatment approaches in recently diagnosed treated patient cohort.
Central serous chorioretinopathy (CSC), characterized by detachment of the macula, is a clinically important retinal disease presenting as various visual symptoms. Predisposing psychopathological factors have been investigated and psychological stress, specific personality profiles psychiatric disorders were suggested relevant factors. These psychic induce hormonal changes stimulating sympathetic nervous system, thus aggravating extravasation fluid from choroid. Psychotherapeutic strategies...
<title>Abstract</title> Purpose To identify genetic influences on subfoveal choroidal thickness using a genome-wide association study (GWAS). Methods We recruited 300 participants from the population-based Korean Longitudinal Study Health and Aging (KLoSHA) Cognitive Dementia (KLOSCAD) cohort studies 500 Bundang age-related macular degeneration (AMD) dataset. conducted GWAS older adult populations in KLoSHA KLOSCAD cohorts. Single nucleotide polymorphisms (SNPs) associated with were...
To identify longitudinal retinal layer thickness changes in normal eyes of cognitively healthy elderly people.
To identify genetic influences on subfoveal choroidal thickness of older adults using a genome-wide association study (GWAS). We recruited 300 participants from the population-based Korean Longitudinal Study Health and Aging (KLoSHA) Cognitive Dementia (KLOSCAD) cohort studies 500 Bundang age-related macular degeneration (AMD) dataset. conducted GWAS adult populations in KLoSHA KLOSCAD cohorts. Single nucleotide polymorphisms (SNPs) associated with were identified P values < 1.0 × 10
Abstract Background To elucidate the biological mechanisms underpinning association between macular Retinal Nerve Fiber Layer (RNFL) thickness and cognitive function in older adults, this study investigates its correlation with brain volume cortical thickness. Method From a community‐dwelling prospective cohort, we included 166 non‐demented participants aged over 65 years (mean age 75.2 ± 5.3; 61.4% women) who had 3D T1 MRI images no ocular pathologies that could affect retinal layer Using...
Introduction: This study was conducted to assess the systemic pharmacokinetic profiles of half-dose verteporfin photodynamic therapy (PDT) using concentration data from a previous clinical trial, and subsequently suggest safety precaution guidelines. Methods: Coefficients for bi-exponential model were obtained published on post-infusion plasma concentrations within period 0.17–4 h. Using extrapolative forecasting method, we plotted 48 h post-verteporfin model. The time required achieve...
Our website uses cookies to enhance your experience. By continuing use our site, or clicking "Continue," you are agreeing Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications Network Open Cardiology Dermatology Health Forum Internal Medicine Neurology Oncology Otolaryngology–Head & Neck Surgery Pediatrics Psychiatry Archives of (1919-1959) JN Learning / CMESubscribeJobsInstitutions LibrariansReprints Permissions Terms Use Privacy...
To investigate the incidence and clinical features of red blood cell (RBC)-coated intraocular lens (IOL) in breakthrough vitreous hemorrhage (VH) with subretinal (SRH) secondary to neovascular age-related macular degeneration (nAMD).Seoul National University Bundang Hospital, Seongnam, Korea.Retrospective cohort analysis.A total 30 patients diagnosed as VH SRH nAMD who underwent pars plana vitrectomy were included this study. Demographics characteristics subjects, visual acuities, sizes...