A5113255134- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Wound Healing and Treatments
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Surgical Sutures and Adhesives
- Proteoglycans and glycosaminoglycans research
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Tendon Structure and Treatment
- Hemostasis and retained surgical items
- Retinopathy of Prematurity Studies
- Coronary Interventions and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Cellular Mechanics and Interactions
- Advancements in Transdermal Drug Delivery
Ajou University
2016-2025
Government of the Republic of Korea
2015-2020
Suwon Research Institute
2014-2019
PRG S&Tech (South Korea)
2015
Hanyang University
2010
Yonsei University
2003
Korea Institute of Science and Technology
1993-2002
Seoul National University
1993-2002
New Generation University College
2002
Konkuk University
1993
An in situ gel-forming system composed of rutin- and tyramine-conjugated chitosan derivatives, horseradish peroxidase (HRP), hydrogen peroxide (H2O2) was prepared applied to dermal wound repair. Rutin employed enhance production accumulation extracellular matrix the healing process. In vitro study demonstrates that released rutin significantly enhanced cell proliferation as compared with media without rutin. vivo performed by injecting hydrogels on rat dorsal wounds a diameter 8 mm for 14...
Abstract Heparin was immobilized onto segmented polyurethane‐urea surfaces (Biomer) using hydrophilic poly(ethylene oxide) spacers of different chain lengths. The use the spacer, oxide), reduces protein adsorption and subsequent platelet adhesion on surface. In addition, bioactivity heparin is enhanced by incorporation these spacers. Immobilized shown to be a function PEO spacer length. Use demonstrates that heparin's consistently higher than C 6 alkyl but heparin‐immobilized demonstrate no...
Over the past decades, hydrogels have been widely studied as biomaterials for various biomedical applications like implants, drugs and cell delivery carriers because of their high biocompatibility, water contents excellent permeability nutrients metabolites. Especially, in situ forming hydrogel systems received much attention easy application based on minimal invasive techniques. Chemical cross-linking fabricated using enzymatic reactions advantages, such biocompatibility control reaction...
The present study describes enzymatically cross-linked gelatin-based hydrogels as in situ forming tissue adhesives. A series of gelatin derivatives with different phenolic contents were synthesized by conjugating hydroxyphenyl propionic acid and tyramine to backbones. Two derivatives, gelatin–hydroxyphenyl (GH) acid–tyramine (GHT) maximum obtainable (146.6 μmol g−1 GH 395.7 GHT), used prepare via horseradish peroxidase (HRP)-mediated reactions the presence hydrogen peroxide (H2O2). By...
An in situ cross-linkable gelatin–poly(ethylene glycol)–tyramine (GPT) hydrogel was developed as a novel injectable material for tissue regenerative medicine. The formed rapidly using horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). gelation times could be controlled from five seconds to over one minute by changing the HRP concentration, mechanical properties varying H2O2 concentration. storage moduli of hydrogels ranged approximately 200 8000 Pa. In addition, an vitrocell...
In situ nitric oxide generation from copper-containing hydrogel enhances anti-inflammatory, cell migration, and angiogenic processes for promoted wound healing.
In situ forming hydrogels show promise as therapeutic implants and carriers in a wide range of biomedical applications. They can easily seal or fill damaged tissue, thereby functioning cell/drug delivery vehicles hemostats. this regard, strong stable adhesion to the surrounding tissue is considered an important parameter improve vivo performance hydrogels. study, tissue-adhesive gelatin-based were prepared by dual-enzymatic cross-linking, where horseradish peroxidase (HRP) tyrosinase (Tyr)...
In this study, in situ forming gelatin hydrogels via horseradish peroxidase (HRP)-catalyzed cross-linking were developed to serve as bioactive wound dressings with suitable tissue adhesive properties deliver dermal fibroblasts (DFBs). The DFB-encapsulated different stiffnesses, GH-soft (1.1 kPa) and GH-hard (6.2 kPa), prepared by controlling the hydrogen peroxide (H2O2) concentrations. hydrogel was capable of facilitating proliferation DFBs synthesis extracellular components, compared...
Fast in situ forming supramolecular hydrogels consisted of the tyramine-conjugated structures and chitosan derivative were prepared via an enzymatic reaction with horseradish peroxidase (HRP) hydrogen peroxide (H2O2). The gel formation was varied within a time period 5 s to 10 min by controlling concentrations HRP, H2O2, polymers. Tyramine conjugation at different sites structure resulted significant changes physical properties degradation that confirmed water uptake, compressive strength...