A5038765769- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Frailty in Older Adults
- Nutrition and Health in Aging
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Alzheimer's disease research and treatments
- Sleep and related disorders
- Health, Environment, Cognitive Aging
- Neurobiology of Language and Bilingualism
- Health disparities and outcomes
- Sleep and Wakefulness Research
- Genetic Associations and Epidemiology
- Obesity, Physical Activity, Diet
- Restless Legs Syndrome Research
- Cognitive Functions and Memory
- Health and Well-being Studies
- Stroke Rehabilitation and Recovery
- Health Literacy and Information Accessibility
- COVID-19 and Mental Health
- Folate and B Vitamins Research
- Palliative Care and End-of-Life Issues
- Long-Term Effects of COVID-19
- Sleep and Work-Related Fatigue
Greek Association of Alzheimer's Disease and Related Disorders
2015-2025
Alzheimer's Association
2024
National and Kapodistrian University of Athens
1983-2021
University of Thessaly
2019-2021
Harokopio University of Athens
2019-2021
Columbia University
2019-2021
Aristotle University of Thessaloniki
2019-2021
University of Cyprus
2019-2021
The University of Texas Health Science Center at San Antonio
2021
National Institute on Aging
2021
The Mediterranean dietary pattern has been associated with a decreased risk of many degenerative diseases and cognitive function in particular; however, relevant information from regions, where the prototype diet is typically adhered to, have very limited. Additionally, predefined (MeDi) scores use priori cut-offs used rarely, limiting comparisons between different populations thus external validity associations. Finally, associations individual components MeDi (i.e., food groups,...
The International Parkinson and Movement Disorder Society recently introduced a methodology for probability score calculation prodromal PD.To assess the of PD in an older population investigate its possible association with Mediterranean diet adherence.Data from population-based cohort study adults (HEllenic Longitudinal Investigation Aging Diet) Greece were used. Probability was calculated according to research criteria. A detailed food frequency questionnaire used evaluate dietary intake...
Objective The aim of this paper was to assess the efficacy process-based cognitive training (pb-CT) combined with reminiscence therapy (RT) in patients mild Alzheimer's disease (mAD) and impairment (MCI) healthy elderly (HE) subjects. Methods This multicenter, randomized, controlled trial involved 348 participants mAD, MCI, HE from four European countries. Participants were randomly assigned two arms a crossover design: those arm A underwent 3 months computerized pb-CT for memory executive...
Aging is characterized by a functional shift of the immune system toward proinflammatory phenotype. This derangement has been associated with cognitive decline and implicated in pathogenesis dementia. Diet can modulate systemic inflammation; thus, it may be valuable tool to counteract risk for impairment The present study aimed explore associations between inflammatory potential diet, assessed an easily applicable, population-based, biomarker-validated diet index (DII), dementia...
Abstract Background Current evidence suggests that nutrition in general and specific dietary patterns particular, such as the Mediterranean type diet (MeDi), can be employed potential preventive strategies against development of dementia cognitive decline. However, longitudinal data exploring applicability these findings populations origin are limited. The aim present study was to explore relationships MeDi adherence with incidence rates change over time a traditional population,...
<h3>Objective</h3> To investigate the effects of completed pregnancy with childbirth and incomplete without on late-life cognition risk Alzheimer disease (AD) in women. <h3>Methods</h3> Using pooled data 3,549 women provided by 2 population-based cohort studies, we conducted logistic regression analyses to examine retrospectively associations risks mild cognitive impairment AD. For dementia, also covariance Mini-Mental State Examination (MMSE) score. <h3>Results</h3> Grand multiparous who...
Subjective cognitive decline may reflect a dementia prodrome or modifiable risk factor such as sleep disturbance. What is the association between and subjective decline? Cross-sectional design, from two studies of older adults: WHICAP in USA HELIAD Greece. A total 1,576 1,456 participants, without mild impairment, severe depression/anxiety, were included. Participants mostly women, with 12 (WHICAP) 8 (HELIAD) mean years education. Sleep problems estimated using Scale Medical Outcomes Study....
Many lifestyle factors have been linked to cognitive function but little is known about their combined effect. An overall pattern for people living in the Mediterranean basin has proposed, including diet, also physical activity, sleep and daily activities with social/intellectual aspects. We aimed examine associations between a combination of these detailed performance. A total 1716 participants from Hellenic Longitudinal Investigation Ageing Diet (HELIAD), population-based study ≥65 years,...
Introduction: Study of the epidemiology dementia to gain insight into putative predisposing and prophylactic factors is first step toward establishing effective preventive therapeutic strategies for this ever-growing public health problem. Relevant data in Greece are scattered outdated. Methods: We investigated prevalence as part a population-representative epidemiological study [Hellenic Longitudinal Investigation Aging Diet (HELIAD)] 2 Greek regions. Results: Our sample comprised 1792...
Although research has generally shown a negative association between depression and adherence to the Mediterranean diet (MeDi), literature related older adults is controversial, perhaps partially due fact that cognitive status not been considered. The aim of current work was investigate MeDi incident in representative cohort people, taking into account their multiple ways. sample drawn from HELIAD study, longitudinal study including follow-up 3 years after baseline assessment. In total, 879...
Lifestyle factors have been implicated in the long-lasting neurodegenerative process prodromal Parkinson's disease (pPD). The aim was to investigate associations between adherence a Mediterranean diet (MeDi) and longitudinal changes of pPD probability development (PD) or older population.Data from Hellenic Longitudinal Investigation Aging Diet cohort (community-dwelling individuals, aged ≥ 65 years) were used. A detailed food frequency questionnaire used evaluate dietary intake calculate...
A comparison of a group chronic schizophrenics with controls showed that: the patients had significantly less interest in sex, frequency intercourse, and satisfaction from sex; percentage individuals sexual dreams fantasies did not differ between two groups; severity psychopathology influenced intercourse length institutionalization variety disorders, but there was significant difference sexes disturbances thought perception; and, more male schizophrenics, females, dysfunction associated...
Although there is some evidence of the relationships between sleep duration/quality and nutrient and/or food intake, associations dietary patterns have been poorly explored. The aim present study was to evaluate duration quality in relation adherence Mediterranean diet (MeDi), investigate sex- age-specific a population-representative cohort older adults.Participants from Hellenic Longitudinal Investigation Aging Diet were included. sample consisted 1639 adults aged ≥65 years. Sleep assessed...
Introduction: Timely recognition of mild cognitive impairment (MCI) is essential in optimizing prevention and treatment for Alzheimer disease. Because the paucity data on MCI epidemiology Greece variability worldwide published results, we investigated prevalence determinants elderly population Greece. Methods: As part Hellenic Epidemiological Longitudinal Investigation Aging Diet (HELIAD), randomly selected 1960 individuals 65 years older to undergo full neurological neuropsychological...
Objective To determine the longitudinal trajectories and normative standards of episodic memory in older adults.Methods Participants were drawn from cognitively normal(CN) subgroup population-based HELIAD cohort, a fairly representative cohort Greek population. Verbal non-verbal assessed using Learning Test Medical College Georgia-Complex Figure Test. Baseline associations performance with age, sex formal education explored linear regression analysis generalized estimated equations.Results A...
Abstract Objective To investigate differences in language performance among older adults with normal cognition (CN), mild cognitive impairment (MCI), and Alzheimer’s disease (ad). Owing to the conflicting literature concerning MCI, discrepancies between amnestic (aMCI) non-amnestic MCI (naMCI) were explored greater detail. Method The study sample was drawn from (&gt;64 years) HELIAD cohort. Language assessed via semantic phonemic fluency, confrontation naming, verbal comprehension,...
Aging is accompanied by immune dysregulation, which has been implicated in Alzheimer's disease (AD) pathogenesis. Individuals who are genetically predisposed to elevated levels of proinflammatory mediators might be at increased risk for AD. To investigate whether genetic propensity higher circulating interleukin 6 (IL-6) associated with AD risk. We analyzed data from the Hellenic Longitudinal Investigation and Diet (HELIAD). Mean follow-up was 2.9 (SD, 0.8) years. Baseline assessment 11/2009...
In the present study, we investigated association of genetic predisposition with specific dimensions dementia pathophysiology for global and domain-specific cognitive decline in older adults. The sample was drawn from Hellenic Longitudinal Investigation Aging Diet (HELIAD) comprising 512 cognitively normal individuals over 64 years age, a mean follow-up 2.9 years. Cognitive function evaluated through neuropsychological test battery, while assessed based on two distinct Polygenic Risk Scores...
Abstract Depressive symptoms are common in mild cognitive impairment (MCI), dementia caused by Alzheimer’s disease (AD dementia) and cognitively unimpaired older adults. However, it is unclear whether they could contribute to the identification of ageing. To assess potential utility depressive distinguish between healthy ageing MCI AD dementia. The diagnostic workup function 1737 individuals, 334 people with 142 individuals relied on a comprehensive neuropsychiatric assessment, including...
The pilot phase of the Greek Interventional Geriatric Initiative to Prevent Cognitive Impairment and Disability (GINGER) aims assess feasibility a multi-level dementia risk reduction intervention in individuals with subjective cognitive decline (SCD) over six-month period. study design incorporates comprehensive set trans-disciplinary assessments interventions multiple centers across Greece. Individuals 55 years or older complaints who do not fulfill criteria for either mild impairment are...