A5042650138- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Autism Spectrum Disorder Research
- Migraine and Headache Studies
- Nuclear Receptors and Signaling
- Dementia and Cognitive Impairment Research
- Neurological diseases and metabolism
- Cerebrovascular and genetic disorders
- Botulinum Toxin and Related Neurological Disorders
- Lysosomal Storage Disorders Research
- RNA regulation and disease
- MicroRNA in disease regulation
- Amyotrophic Lateral Sclerosis Research
- Restless Legs Syndrome Research
- Genetic Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Circular RNAs in diseases
- Health, psychology, and well-being
- Ginkgo biloba and Cashew Applications
- Respiratory and Cough-Related Research
- Transcranial Magnetic Stimulation Studies
- COVID-19 Clinical Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Global Health Care Issues
Eginition Hospital
2016-2025
National and Kapodistrian University of Athens
2016-2025
Laiko General Hospital of Athens
2024
Istanbul Health and Technology University
2023
Istanbul University
2023
Biomedical Research Foundation of the Academy of Athens
2018-2022
Institute for Language and Speech Processing
2015-2021
Academy of Athens
2018-2021
Hygeia Hospital
2019-2021
Ludwig-Maximilians-Universität München
2021
The Mediterranean dietary pattern has been associated with a decreased risk of many degenerative diseases and cognitive function in particular; however, relevant information from regions, where the prototype diet is typically adhered to, have very limited. Additionally, predefined (MeDi) scores use priori cut-offs used rarely, limiting comparisons between different populations thus external validity associations. Finally, associations individual components MeDi (i.e., food groups,...
ABSTRACT Background The SNCA gene encoding α‐synuclein (αSyn) is the first identified to cause autosomal‐dominant Parkinsonʼs disease (PD). Objective We report identification of a novel heterozygous A30G mutation in familial PD and describe clinical features affected patients, genetic findings, functional consequences. Methods Whole exome sequencing was performed discovery family proband. Restriction digestion with Bbvl used screen two validation cohorts. Greek cohort included 177 probands,...
(1) Background: Wearable sensors have emerged as a promising technology in the management of Parkinson’s disease (PD). These can provide continuous and real-time monitoring various motor non-motor symptoms PD, allowing for early detection intervention. In this paper, I review current research on application wearable focusing gait, tremor, bradykinesia, dyskinesia monitoring.(2) Methods: involved literature search that spanned 2000–2024 period included following keywords: “wearable sensors”,...
To assess the prevalence of laryngopharyngeal reflux (LPR) in Greek general population and its risk factors.Questionnaire based epidemiological, adult participants' survey. The Reflux Symptom Index (RSI) was used for assessment LPR prevalence. RSI questionnaire completed by 340 (183 male 157 female) randomly selected subjects. Subjects with score ≥13 were considered as patients those <13 non subjects.The found to be 18.8 % no statistically significant difference between two genders (p >...
Abstract Background New noninvasive and affordable molecular approaches that will complement current practices increase the accuracy of Parkinson's disease (PD) diagnosis are urgently needed. Circular RNAs (circRNAs) stable noncoding accumulate with aging in neurons increasingly shown to regulate all aspects neuronal development function. Objectives Τhe aims this study were identify differentially expressed circRNAs blood mononuclear cells patients idiopathic PD explore competing endogenous...
A minimally invasive test for early detection and monitoring of Parkinson's disease (PD) is a highly unmet need drug development planning patient care. Blood plasma represents an attractive source biomarkers. MicroRNAs (miRNAs) are conserved noncoding RNA molecules that serve as posttranscriptional regulators gene expression. As opposed to ubiquitously expressed miRNAs control house-keeping processes, brain-enriched regulate diverse aspects neuron function. These include neuron-subtype...
<b><i>Background:</i></b> Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are nowadays recognized as spectrum disorders with a molecular link, the TAR DNA-binding protein 43 (TDP-43), rendering it surrogate biomarker for these disorders. <b><i>Methods:</i></b> We measured cerebrospinal fluid (CSF) levels of TDP-43, beta-amyloid peptide 42 amino acids (Aβ<sub>42</sub>), total tau (τ<sub>T</sub>),...
There is a pressing need to identify and validate, minimally invasive, molecular biomarkers that will complement current practices increase the diagnostic accuracy in Parkinson's disease (PD). Brain-enriched miRNAs regulate all aspects of neuron development function; importantly, they are secreted by neurons amounts can be readily detected plasma. Τhe aim present study was validate set previously identified brain-enriched with potential for idiopathic PD recognize pathways affected these...
(1) Background: Wearable sensors have emerged as a promising technology in the management of Parkinson&#039;s Disease (PD). These can provide continuous and real-time monitoring various motor non-motor symptoms PD, allowing for early detection intervention. In this abstract, i review current research on application wearable focusing gait, tremor, bradykinesia, dyskinesia monitoring. (2) Methods: This is literature spanning 2000-2024 period including following keywords: “wearable...
(1) Background: Since there is no definite cure for Parkinsons Disease (PD) a growing interest novel therapeutical agents with neuroprotective potential. Aim of this review to update the knowledge nuclear factor-erythroid 2-related factor 2(Nrf2) as agent ; (2) Methods: briefly describe main methods or treatments applied; (3) Results: Activation Nrf2, transcription that regulates expression antioxidant and cytoprotective genes, has emerged promising therapeutic strategy PD. Nrf2 master...
There is growing evidence that headaches are connected to melatonin secretion. Our aim was assess the potential effectiveness of for primary headache prevention. Forty-nine patients (37 with migraine and 12 chronic tension-type headache, TTH) were prescribed oral melatonin, 4 mg, 30 minutes before bedtime six months. Forty-one (83.6%) 49 completed study, while eight dropped out personal reasons. A statistically significant reduction in frequency found between baseline final follow-up after...
Given the limited information on cognitive function before Parkinson disease (PD) clinical onset in general population, we sought to assess prodromal PD (pPD) probability and relate it detailed performance a community cohort.In population-based cohort of 1,629 dementia-free PD-free participants ≥65 years age Greece, assessed pPD according International Movement Disorder Society's criteria. Clinical diagnoses (cognitively unimpaired, mild impairment [MCI], dementia) considering...
Background: The role of blood uric acid as a biomarker in symptomatic motor PD has been increasingly established the literature. Objective: Our present study assessed serum putative prodromal cohort [REM Sleep Behavior disorder (RBD) and Hyposmia] followed longitudinally. Methods: Longitudinal 5-year measurement data 39 RBD patients 26 Hyposmia with an abnormal DATSCAN imaging were downloaded from Parkinson’s Progression Markers Initiative database. These cohorts compared 423 de novo 196...