A5066578279- Nutritional Studies and Diet
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Eating Disorders and Behaviors
- Alzheimer's disease research and treatments
- Folate and B Vitamins Research
- Gut microbiota and health
- Mobile Health and mHealth Applications
- Sleep and related disorders
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Diet, Metabolism, and Disease
- Child Nutrition and Feeding Issues
- Nutrition, Genetics, and Disease
- Sodium Intake and Health
- Obesity and Health Practices
- Sleep and Work-Related Fatigue
- Frailty in Older Adults
- Tryptophan and brain disorders
- Health Systems, Economic Evaluations, Quality of Life
- Traumatic Brain Injury and Neurovascular Disturbances
- Physical Activity and Health
- Nutrition, Health and Food Behavior
Eginition Hospital
2023-2025
Harokopio University of Athens
2016-2025
National and Kapodistrian University of Athens
2023-2025
Many lifestyle factors have been linked to cognitive function but little is known about their combined effect. An overall pattern for people living in the Mediterranean basin has proposed, including diet, also physical activity, sleep and daily activities with social/intellectual aspects. We aimed examine associations between a combination of these detailed performance. A total 1716 participants from Hellenic Longitudinal Investigation Ageing Diet (HELIAD), population-based study ≥65 years,...
Although research has generally shown a negative association between depression and adherence to the Mediterranean diet (MeDi), literature related older adults is controversial, perhaps partially due fact that cognitive status not been considered. The aim of current work was investigate MeDi incident in representative cohort people, taking into account their multiple ways. sample drawn from HELIAD study, longitudinal study including follow-up 3 years after baseline assessment. In total, 879...
Although there is some evidence of the relationships between sleep duration/quality and nutrient and/or food intake, associations dietary patterns have been poorly explored. The aim present study was to evaluate duration quality in relation adherence Mediterranean diet (MeDi), investigate sex- age-specific a population-representative cohort older adults.Participants from Hellenic Longitudinal Investigation Aging Diet were included. sample consisted 1639 adults aged ≥65 years. Sleep assessed...
Aging is accompanied by immune dysregulation, which has been implicated in Alzheimer's disease (AD) pathogenesis. Individuals who are genetically predisposed to elevated levels of proinflammatory mediators might be at increased risk for AD. To investigate whether genetic propensity higher circulating interleukin 6 (IL-6) associated with AD risk. We analyzed data from the Hellenic Longitudinal Investigation and Diet (HELIAD). Mean follow-up was 2.9 (SD, 0.8) years. Baseline assessment 11/2009...
In the present study, we investigated association of genetic predisposition with specific dimensions dementia pathophysiology for global and domain-specific cognitive decline in older adults. The sample was drawn from Hellenic Longitudinal Investigation Aging Diet (HELIAD) comprising 512 cognitively normal individuals over 64 years age, a mean follow-up 2.9 years. Cognitive function evaluated through neuropsychological test battery, while assessed based on two distinct Polygenic Risk Scores...
Abstract As sleep appears to be closely related cognitive status, we aimed explore the association between percentage of deep sleep, state, and cerebrospinal fluid (CSF) biomarker amyloid-beta 42 in non-demented individuals. In this cross-sectional study, 90 participants from Aiginition Longitudinal Biomarker Investigation Neurodegeneration cohort underwent a one-night WatchPAT evaluation. Participants were categorized by status (patients with mild impairment [MCI] or cognitively normal [CN]...
According to a WHO statement, it has been asserted that there is no safe level of alcohol consumption regarding human health. Nevertheless, the relationship between and Alzheimer's disease (AD) pathology remains unclear. Therefore, we examined whether frequency patterns could predict neurodegeneration biomarkers in cohort middle-aged adults without dementia. A total 195 participants dementia were included from ALBION study. Multivariate logistic regression analyses conducted using drinking...
The aim of the current study was to investigate whether a Total Lifestyle Index (TLI), including adherence Mediterranean diet, sleep duration, physical activity and engagement in activities daily living, is associated with cognitive health over time dementia risk, representative cohort older people. A total 1018 non-demented community-dwelling adults ≥65 years old (60% women) from HELIAD were included. comprehensive neurological neuropsychological assessment conducted at baseline 3-year...
Given the increase in aging population and thus prevalence of dementia, identification protective factors against cognitive decline is necessary. In a cohort 1076 non-demented adults ≥ 65 years old (59.7% women) from HELIAD study, we assessed whether changes body mass index (BMI) were associated with cognition over 3-year follow-up period separately for those ≤ 75 >75 old. We identified six BMI trajectory groups based on participants' status at baseline first visit; normal to was reference...
The role of Bifidobacterium species and microbial metabolites such as short-chain fatty acids (SCFAs) human milk oligosaccharides in controlling intestinal inflammation the pathogenesis obesity type 1 diabetes (T1D) has been largely studied recent years. This paper discusses discovery signature biomarkers for T1D based on data from a novel test profiling several species, combined with metabolomic analysis. Through NUTRISHIELD clinical study, total 98 children were recruited: 40 healthy...
Abstract Gut microbiome composition has been associated with early preclinical Alzheimer’s disease (AD), as reflected by cerebrospinal fluid (CSF) amyloid beta pathology, and mild cognitive impairment (MCI). However, the presence of distinct microbiota across different stages not fully characterized. We profiled gut in 50 nondemented individuals 16S ribosomal RNA sequencing taxonomic profiles were compared between amyloid-based (amyloid-normal vs. amyloid-pathology) clinically- based...
Background and Objectives: This article presents data from the ongoing Aiginition Longitudinal Biomarker Investigation of Neurodegeneration study (ALBION) regarding baseline clinical characterizations CSF biomarker profiles, as well preliminary longitudinal on progression. Materials Methods: As March 2022, 138 participants who either were cognitively normal (CN, n = 99) or had a diagnosis mild cognitive impairment (MCI, 39) been recruited at specialist disorders outpatient clinic Hospital....
Abstract Objective: The present study aimed to explore the associations between social life and adherence a healthy dietary pattern, Mediterranean diet (MD), in population-representative cohort of older people. Design: Cross-sectional study. Adherence MD was evaluated by an priori score; tertiles score, indicating low, medium high adherence, were used analyses. Social assessed questionnaire evaluating participation leisure-time activities number contacts; primary occupation also recorded job...
Objectives: Aiginition Longitudinal Biomarker Investigation Of Neurodegeneration (ALBION) is a longitudinal ongoing study initiated in 2018 that takes place the Cognitive Disorders Clinic of Hospital National and Kapodistrian University Athens. Its aim to address several research questions concerning preclinical prodromal stage Alzheimer's disease explore potential markers for early detection, prediction, primary prevention dementia. Methods: We here present design preliminary baseline...