A5078561388- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Muscle Physiology and Disorders
- Advanced X-ray Imaging Techniques
- Laser-Plasma Interactions and Diagnostics
- Cooperative Communication and Network Coding
- Force Microscopy Techniques and Applications
- Laser-Matter Interactions and Applications
- Cellular Mechanics and Interactions
- Nuclear Structure and Function
- Advanced Electron Microscopy Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Cognitive Radio Networks and Spectrum Sensing
- Wireless Communication Security Techniques
- Tissue Engineering and Regenerative Medicine
- Genetic Neurodegenerative Diseases
- Electron and X-Ray Spectroscopy Techniques
- RFID technology advancements
- X-ray Spectroscopy and Fluorescence Analysis
- Digital Holography and Microscopy
- Health and Wellbeing Research
- Cardiovascular Function and Risk Factors
- Shoulder Injury and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Dementia and Cognitive Impairment Research
University of Massachusetts Chan Medical School
2014-2023
Samsung (South Korea)
2023
Seoul National University Bundang Hospital
2018-2021
BongSeng Memorial Hospital
2018-2020
Institute for Basic Science
2015-2020
Seoul National University
2020
UMass Memorial Medical Center
2017
Korea Advanced Institute of Science and Technology
2009-2013
Gwangju Institute of Science and Technology
2013
Korea Institute of Energy Research
2013
To investigate sleep disturbances that induce cognitive changes over 4 years in nondemented elderlies.Data were acquired from a nationwide, population-based, prospective cohort of Korean elderlies (2,238 normal cognition [NC] and 655 mild impairment [MCI]). At baseline 4-year follow-up assessments, sleep-related parameters (midsleep time, duration, latency, subjective quality, efficiency, daytime dysfunction) status measured using the Pittsburgh Sleep Quality Index Consortium to Establish...
Significance All animals have the ability to move. Myosin II is motor protein that generates this movement by powering muscular contraction; it also drives motility in nonmuscle cells. In relaxed muscle and quiescent cells, myosin switched off intramolecular interactions between its heads inhibit activity. This interacting-heads motif (IHM) a fundamental contributor contractile regulation. Given importance cell contractility, we wanted determine when IHM first evolved. Using electron...
In this paper, we investigate the outage performance of cognitive wireless relay networks where source nodes communicate to their destinations via multiple hops facilitated by intermediate able acquire spectrum holes. Specifically, consider a model that consists node, destination and group network clusters each consisting number (unlicensed) primary (licensed) node. Cognitive information from depending on geographical proximity ability hole successfully. We high SNR approximation probability...
To explore the physiological significance of N-glycan maturation in plant Golgi apparatus, gnt1, a mutant with loss N-acetylglucosaminyltransferase I (GnTI) function, was isolated Oryza sativa. gnt1 exhibited complete inhibition and accumulated high-mannose N-glycans. Phenotypic analyses revealed that shows defective post-seedling development incomplete cell wall biosynthesis, leading to symptoms such as failure tiller formation, brittle leaves, reduced thickness, decreased cellulose...
The beating heart exhibits remarkable contractile fidelity over a lifetime, which reflects the tight coupling of electrical, chemical, and mechanical elements within sarcomere, elementary unit. On beat-to-beat basis, calcium is released from ends sarcomere must diffuse toward center to fully activate myosin- actin-based proteins. resultant spatial temporal gradient in free across should lead nonuniform inefficient activation contraction. We show that myosin-binding protein C (MyBP-C),...
The Spo0B-associated GTP-binding protein (Obg) GTPase, essential for bacterial viability, is also conserved in eukaryotes, but its primary role eukaryotes remains unknown. Here, our functional characterization of Arabidopsis and rice obgc mutants strongly underlines the evolutionarily eukaryotic Obgs organellar ribosome biogenesis. exhibited a chlorotic phenotype, caused by retarded chloroplast development. A plastid DNA macroarray revealed plastid-encoded RNA polymerase (PEP) deficiency an...
Myosin and actin filaments are highly organized within muscle sarcomeres. Myosin-binding protein C (MyBP-C) is a flexible, rod-like located the C-zone of sarcomere. The C-terminal domain MyBP-C tethered to myosin filament backbone, N-terminal domains postulated interact with and/or head modulate sliding. To define where localized in sarcomere active relaxed mouse myocardium, relative positions N terminus were imaged fixed samples using super-resolution fluorescence microscopy. resolution...
Striated muscle contraction involves sliding of actin thin filaments along myosin thick filaments, controlled by calcium through filament activation. In relaxed muscle, the two heads interact with each other on surface to form interacting-heads motif (IHM). A key question is how both are released from approach and produce force. We used time-resolved synchrotron X-ray diffraction study tarantula before after tetani. The patterns showed that IHM present in live muscle. Tetanic produced only a...
Fast skeletal myosin-binding protein-C (fMyBP-C) is one of three MyBP-C paralogs and predominantly expressed in fast muscle. Mutations the gene that encodes fMyBP-C,
<b><i>Background:</i></b> The aim of this study was to investigate the association gait speed and variability, an index how much parameters, such as step time, fluctuate step-to-step, with risk cognitive decline in cognitively normal elderly individuals. While high variability is emerging early indicator dementing illnesses, there little research on whether predicts who have no evidence impairment. <b><i>Methods:</i></b> In 4-year prospective...
Myocyte disarray is a hallmark of many cardiac disorders. However, the relationship between alterations in orientation individual myofibrils and myofilaments to disease progression has been largely underexplored. This oversight predominantly because paucity methods for objective quantitative analysis. Here, we introduce novel, less-biased approach quantify myofibrillar myofilament muscle under near-physiological conditions demonstrate its superiority as compared with conventional...
Transient asynchrony induced by an implanted pacemaker improves pathobiology of heart failure in large animals.
Myosin binding protein-C (MyBP-C) exists in three major isoforms: slow skeletal, fast and cardiac. While cardiac MyBP-C (cMyBP-C) expression is restricted to the heart adult, it transiently expressed neonatal stages of some skeletal muscles. However, unclear whether this necessary for proper development function muscle. Our aim was determine absence cMyBP-C alters structure, function, or isoform adult muscle using a null mouse model (cMyBP-C(t/t)). Slow both muscles, whereas mostly...
Abstract Aims A 25-base pair deletion in the cardiac myosin binding protein-C (cMyBP-C) gene (MYBPC3), proposed to skip exon 33, modifies C10 domain (cMyBP-CΔC10mut) and is associated with hypertrophic cardiomyopathy (HCM) heart failure, affecting approximately 100 million South Asians. However, molecular mechanisms underlying pathogenicity of cMyBP-CΔC10mutin vivo are unknown. We hypothesized that expression cMyBP-CΔC10mut exerts a poison polypeptide effect leading improper assembly...
An RFID tag antenna with electric-thread using a sewing machine is proposed. The characteristics of the used as are studied and changes conductivity for different methods analyzed. electro-thread designed by shape alphabet characters. radiation efficiency about 33% measured maximum reading range 2.5m in an anechoic chamber. It demonstrated that possible to be directly applied clothes brand or company marks. However, it necessary develop some additional technology packaging protect chip from...
We investigated the effects of lifetime cumulative ginseng intake on cognitive function in a community-dwelling population-based prospective cohort Korean elders. Community-dwelling elders (N = 6422; mean age 70.2 ± 6.9 years, education 8.0 5.3 female 56.8%) from Longitudinal Study Cognitive Aging and Dementia were included. Among them, 3918 participants (61.0%) completed 2-year 4-year follow-up evaluations. Subjects categorized according to at baseline evaluation; no use group, low (< 5...
Myosin II is a motor protein with two heads and an extended tail that plays essential role in cell motility. Its active form polymer (myosin filament) pulls on actin to generate motion. inactive monomer compact structure (10S sedimentation coefficient), which the folded interact each other, inhibiting activity. This conformation thought function cells as energy-conserving of molecule suitable for storage well transport sites filament assembly. The mechanism inhibition not fully understood....
Structural and functional studies of heart muscle are important to gain insights into the physiological bases cardiac contraction pathological disease. While fresh tissue works best for these kinds studies, this is not always practical obtain, especially from large animal models humans. Conversely, banks frozen human hearts available could be a tremendous resource translational research. It well understood, however, how liquid nitrogen freezing cryostorage may impact structural integrity...
We consider a wireless communication scenario where multiple unlicensed cognitive users seek to access unused frequency channels licensed the primary users. A main challenge in this case is design spectrum sensing strategy that aids acquire and limits interference Towards addressing challenge, we propose cooperative which collaborate share their decisions regarding occupancy of demonstrate effectiveness proposed aims equip all with information as many possible, observe improves throughput...
A novel UHF RFID metal tag antenna using a cavity structure for long reading range is proposed. The size of the proposed 176.0 x 61.0 31.0 (mm3) and it can be applied large materials heavy equipments. measured about 1 lm in free space 15 m when attached to plate. at 4m better than that space.