A5059375704- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Metabolomics and Mass Spectrometry Studies
- Medical Imaging Techniques and Applications
- Tryptophan and brain disorders
- Gut microbiota and health
- Receptor Mechanisms and Signaling
- Radiopharmaceutical Chemistry and Applications
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Cholinesterase and Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Neurological disorders and treatments
- Synthesis and Biological Evaluation
- Lanthanide and Transition Metal Complexes
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Chromatography
- Alzheimer's disease research and treatments
- Fluorine in Organic Chemistry
- Mitochondrial Function and Pathology
- Attention Deficit Hyperactivity Disorder
Inserm
2016-2025
Centre Hospitalier Universitaire de Tours
2016-2025
Université de Tours
2016-2025
Hôpital Bretonneau
2006-2024
Imagerie et Cerveau
2012-2023
Thion Medical (France)
2022
Centre Val de Loire
2020-2022
Institut National de Recherche en Santé Publique
2018
Université de Poitiers
2015
NYU Langone Health
2015
Antimicrobial C-type lectin regenerating islet-derived 3 gamma (REG3G) is suppressed in the small intestine during chronic ethanol feeding. Our aim was to determine mechanism that underlies REG3G suppression experimental alcoholic liver disease.Interleukin 22 (IL-22) regulates expression of REG3G. Therefore, we investigated role IL-22 mice subjected chronic-binge feeding (NIAAA model).In a mouse model disease, found type innate lymphoid cells produce lower levels IL-22. Reduced production...
The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp end-products are essential intestinal homeostasis. Here, we investigated role metabolites from kynurenine pathway.Targeted quantitative metabolomics was performed in two large human IBD cohorts (1069 patients with IBD). Dextran sodium sulphate-induced colitis experiments mice were used evaluate effects identified...
Chronic alcohol consumption is an important cause of liver-related deaths. Specific intestinal microbiota profiles are associated with susceptibility or resistance to alcoholic liver disease in both mice and humans. We aimed identify the mechanisms by which targeting can improve alcohol-induced lesions.We used human mice, a mouse model transplanted patients prebiotic, pectin, modulate microbiota. Based on metabolomic analyses, we focused tryptophan metabolites, ligands aryl hydrocarbon...
Abstract The biological mechanisms involved in SARS-CoV-2 infection are only partially understood. Thus we explored the plasma metabolome of patients infected with to search for diagnostic and/or prognostic biomarkers and improve knowledge metabolic disturbance this infection. We analyzed 55 45 controls by LC-HRMS at time viral diagnosis (D0). first evaluated ability predict from metabotype D0 an independent population. Next, assessed feasibility predicting disease evolution 7th 15th day....
Autism spectrum disorder (ASD) is a neurodevelopmental with no clinical biomarker. The aims of this study were to characterize metabolic signature ASD and evaluate multiplatform analytical methodologies in order develop predictive tools for diagnosis disease follow-up. Urine samples analyzed using (1)H (1)H-(13)C NMR-based approaches LC-HRMS-based (ESI+ ESI- on HILIC C18 chromatography columns). Data tables obtained from the six modalities training set 46 urine (22 autistic children 24...
Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between gut microbiota and its host. However, factors regulating AhR within gut, which complex metabolomic environment, are poorly understood. This study investigates effect of combination metabolites on activation mechanism AhR. activity was evaluated using both luciferase reporter system mRNA levels target genes human cell lines colonic explants. studied by radioligand-binding assay, nuclear translocation...
Two novel series of iodinated N-substituted analogs 2β-carbomethoxy-3β-(4'-iodophenyl)tropane (β-CIT) and N-(3-iodoprop-(2E)-enyl)-2β-carbomethoxy-3β-(3',4'-disubstituted phenyl)nortropane were synthesized. They evaluated for their inhibitory properties on dopamine (DAT), serotonin (5-HTT), norepinephrine (NET) transporters in rat brain homogenates using [3H]GBR-12935, [3H]paroxetine, [3H]nisoxetine as specific ligands. All new β-CIT exhibited higher DAT selectivity over both 5-HTT NET than...
Pathophysiological mechanisms involved in amyotrophic lateral sclerosis (ALS) are complex and none has identified reliable markers useful routine patient evaluation. The aim of this study was to analyze the CSF patients with ALS by (1)H NMR (Nuclear Magnetic Resonance) spectroscopy order identify biomarkers early stages disease, evaluate biochemical factors ALS.CSF samples were collected from at time diagnosis without neurodegenerative diseases. One two-dimensional analyses performed...
Amyotrophic lateral sclerosis (ALS) is characterized by the absence of reliable diagnostic biomarkers. The aim study was to (i) devise an untargeted metabolomics methodology that reliably compares cerebrospinal fluid (CSF) from ALS patients and controls liquid chromatography coupled high-resolution mass spectrometry (LC-HRMS); (ii) ascertain a metabolic signature use LC-HRMS platform; (iii) identify metabolites for as or pathophysiologic markers. We developed method analyze CSF components...
The selective degeneration of motoneuron that typifies amyotrophic lateral sclerosis (ALS) implicates non‐cell‐autonomous effects astrocytes. However, mechanisms underlying astrocyte‐mediated neurotoxicity remain largely unknown. According to the determinant role astrocyte metabolism in supporting neuronal function, we propose explore metabolic status astrocytes exposed ALS‐associated conditions. We found a significant dysregulation including purine, pyrimidine, lysine, and...
Currently, most clinical studies in metabolomics only consider a single type of sample such as urine, plasma, or feces and use analytical platform, either NMR MS. Although some have already investigated data from multiple fluids, the information is limited to unique platform. On other hand, investigating human metabolome that combine multi-analytical platforms focused on biofluid. Combining types for one patient using multimodal approach (NMR MS) should extend coverage. Pre-analytical phases...
Abstract Background and Purpose Gut bacteria metabolize tryptophan into indoles. Intestinal levels of the metabolite indole‐3‐acetic acid are reduced in patients with alcohol‐associated hepatitis. Supplementation protects against ethanol‐induced liver disease mice. The aim this study was to evaluate effect engineered producing indoles as Aryl‐hydrocarbon receptor (Ahr) agonists. Methods C57BL/6 mice were subjected chronic‐plus‐binge ethanol feeding orally given PBS, control Escherichia coli...
Objectives Alterations in tryptophan (Trp) metabolism have been reported inflammatory diseases, including rheumatoid arthritis (RA). However, understanding whether these alterations participate RA development and can be considered putative therapeutic targets remains undetermined. In this study, we combined quantitative Trp metabolomics the serum from patients with corrective administration of a recombinant enzyme experimental to address question. Methods Targeted was performed on 574...
Infliximab is a chimeric monoclonal antibody that binds to human tumor necrosis factor alpha and approved for refractory rheumatoid arthritis. We studied the association between infliximab concentration long-term control of disease activity in patients with arthritis treated on routine basis both cross-sectional analysis over long term. Trough serum concentrations were measured receiving infusions during period August October 2006. Disease was assessed by Activity Score 28 Joints (DAS28)...