A5090124205- Avian ecology and behavior
- Genetic diversity and population structure
- Toxic Organic Pollutants Impact
- Animal Behavior and Reproduction
- Gut microbiota and health
- Tryptophan and brain disorders
- Genomics and Phylogenetic Studies
- Free Radicals and Antioxidants
- Genetic and phenotypic traits in livestock
- Wildlife Ecology and Conservation
- Medical and Biological Sciences
- Amphibian and Reptile Biology
- Human Health and Disease
- Chemical Reactions and Isotopes
- Genetic and Environmental Crop Studies
- Plant Virus Research Studies
- Fish Ecology and Management Studies
- Plant Pathogens and Resistance
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Identification and Quantification in Food
- Evolution and Paleontology Studies
- Psychosomatic Disorders and Their Treatments
- Plant Disease Resistance and Genetics
- Plant Molecular Biology Research
Palacký University Olomouc
2002-2025
The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp end-products are essential intestinal homeostasis. Here, we investigated role metabolites from kynurenine pathway.Targeted quantitative metabolomics was performed in two large human IBD cohorts (1069 patients with IBD). Dextran sodium sulphate-induced colitis experiments mice were used evaluate effects identified...
Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between gut microbiota and its host. However, factors regulating AhR within gut, which complex metabolomic environment, are poorly understood. This study investigates effect of combination metabolites on activation mechanism AhR. activity was evaluated using both luciferase reporter system mRNA levels target genes human cell lines colonic explants. studied by radioligand-binding assay, nuclear translocation...
Abstract The human aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that pivotal regulator of physiology and pathophysiology. Allosteric inhibition AhR was previously thought to be untenable. Here, we identify carvones as noncompetitive, insurmountable antagonists characterize the structural functional consequences their binding. Carvones do not displace radiolabeled ligands from binding but instead bind allosterically within bHLH/PAS-A region AhR. influence...
Introgression is the incorporation of alleles from one species or semispecies into gene pool another through hybridization and backcrossing. The rate at which this occurs depends on frequency fitness hybrids backcrosses compared to 'pure' individuals. collared flycatcher (Ficedula albicollis) pied (F. hypoleuca) co-exist hybridize low moderate frequencies in a clinal hybrid zone Central Europe islands Gotland Oland off Swedish east coast. Data hatching success suggest that are less fertile...
Targeting the aryl hydrocarbon receptor (AhR) is an emerging therapeutic strategy for multiple diseases (e.g., inflammatory bowel disease). Thermosporothrix hazakensis microbial metabolite 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) a putative AhR endogenous ligand. To improve chemical stability, we synthesized series of ITE mimics. Using in vitro assays, identified 2-(1H-indole-3-carbonyl)-N-methyl thiazole-4-carboxamide (ITE-CONHCH3) as highly potent (EC50 =...
Abstract Across animal taxa, reproductive success is generally more variable and strongly dependent upon body condition for males than females; in such cases, parents able to produce offspring above‐average are predicted sons, whereas unable good should daughters. We tested this hypothesis the collared flycatcher ( Ficedula albicollis ) by cross‐fostering eggs among nests using of foster young that raised fledging as a functional measure their ability fit offspring. As predicted, females...
This paper reports on the structural rearrangement of satellite DNA type I repeats and heterochromatin during dedifferentiation cell cycling mesophyll protoplasts cucumber (Cucumis sativus). These were localized in telomeric chromosomes chromocenters interphase nuclei. The dramatic reduction involves decondensation subtelomeric freshly isolated protoplasts; however, there are not a great many remarkable changes expression profile. In spite that, reformation chromocenters, occurring 48 h...
Abstract Plasmopara halstedii is a biotrophic parasite of sunflower ( Helianthus annuus ). We genetically analysed 162 P. samples collected between 1982 and 2018, representing 3500 km west–east transect across Europe, from France to the Krasnodar region in southern Russia. To assess population genetic structure among isolates, we sequenced two mitochondrial regions cox1 cox2 ), addition analysing eight polymorphic simple sequence repeat (SSR, microsatellite) markers. Sequencing enabled...