A5066559232- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Blood Pressure and Hypertension Studies
- Complement system in diseases
- Diabetes Treatment and Management
- Dialysis and Renal Disease Management
- Neurological Complications and Syndromes
- Organ Transplantation Techniques and Outcomes
- Healthcare Systems and Practices
- Organ Donation and Transplantation
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Neurological and metabolic disorders
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Vasculitis and related conditions
- Acute Kidney Injury Research
- Sodium Intake and Health
- Hormonal Regulation and Hypertension
- Blood groups and transfusion
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Artery Disease Management
- Liver Disease Diagnosis and Treatment
Linköping University
2025
Centre Hospitalier Universitaire de Tours
2015-2024
Hôpital Bretonneau
2014-2024
Université de Tours
2015-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Nantes Université
2021-2024
Inserm
2015-2024
French Clinical Research Infrastructure Network
2017-2024
Institut thématique Immunologie, inflammation, infectiologie et microbiologie
2021-2024
Centre Val de Loire
2024
Summary Background and objectives Renal infarction is an arterial vascular event that may cause irreversible damage to kidney tissues. This study describes the clinical characteristics of patients with renal according underlying mechanism injury. Design, setting, participants, & measurements retrospectively identified 94 diagnosed between 1989 2011 aim highlighting potential correlations demographic, clinical, biologic etiology infarction. Four groups were identified: cardiac origin...
Background: The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure–lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment resistant hypertension at 6 months. We report influence adherence on pressure control. Methods: One hundred six patients with 4 weeks indapamide 1.5 mg/d, ramipril 10 mg/d (or irbesartan 300 mg/d), and amlodipine were randomly assigned plus treatment, or same alone. For spironolactone 25...
Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic are less characterized than primary (thrombotic thrombocytopenic purpura atypical hemolytic uremic syndrome). The relative frequencies outcomes of secondary unknown.
In June 2023, the European Society of Hypertension (ESH) presented and published new 2023 ESH Guidelines for Management Arterial Hypertension, a document that was endorsed by Renal Association (ERA). Following evolution evidence in recent years, several novel recommendations relevant to management hypertension patients with chronic kidney disease (CKD) appeared these Guidelines. These include target office blood pressure (BP) <130/80 mmHg most against BP <120/70 all CKD; use spironolactone...
Clinical trials of direct oral anticoagulants (DOAC) are scarce and inconclusive in patients who receiving dialysis, for whom DOAC not labelled Europe. In a French nationwide registry study on chronic we compared the effectiveness safety off-label use vs approved vitamin K antagonist (VKA).
Metabolic determinants of microalbuminuria remain poorly understood in non-diabetic individuals and particularly women. We investigated both sexes whether an elevated waist circumference (WC) or the presence metabolic syndrome (MetS) predict development albuminuria at 6 years.We studied 2738 subjects from DESIR cohort without diabetes baseline who were followed up for years.At years, 254 [9.3%; 95% confidence interval (CI) 8.2-10.4%] had developed (> = 20 mg/l), which was significantly...
To improve the management of hypertension in French population, Society Hypertension has decided to issue a new set guidelines that include following practical characteristics: usefulness for clinical practice, short, easy-to-read format, comprehensive writing non-physicians, wide dissemination among healthcare professionals and hypertensive assessment their impact with regard public health goals. These guidelines, so-called appointments patient, 15 recommendations, divided into three...
The annual cost of eculizumab maintenance therapy in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic–uremic syndrome (aHUS) exceeds $300,000 per patient. A better understanding pharmacokinetics subsequent individual dose adjustment could reduce this cost. We measured the trough concentration 9 patients with (aHUS, n = 7; PNH, 2) determined: 1) intra- inter-individual variability; influence weight on pharmacokinetics; 3) rate elimination following discontinuation....
In Brief Background Inconsistencies in outcome reporting and frequent omission of patient-centered outcomes can diminish the value trials treatment decision making. We identified critically important domains kidney transplantation based on shared priorities patients/caregivers health professionals. Methods a 3-round Delphi survey, professionals rated importance for 9-point Likert scale provided comments. During rounds 2 3, participants rerated after reviewing their own score, distribution...
Abstract Aims Several reports have suggested a relationship between male sex and albuminuria in Type 2 diabetes, but impact on renal function decline has not been established. Our aim was to describe the influence of diabetes. Methods SURDIAGENE, an inception cohort, consisted 1470 people with Patients without replacement therapy ≥ 3 serum creatinine determinations during follow‐up prior end‐stage disease were included study. Estimated glomerular filtration rate calculated using Chronic...
In patients with end-stage renal disease treated hemodialysis or peritoneal dialysis, hypertension is very common and often poorly controlled. Blood pressure (BP) recordings obtained before after display a J-shaped U-shaped association cardiovascular events survival, but this most likely reflects the low accuracy of these measurements peculiar hemodynamic setting related dialysis treatment. Elevated BP by home ambulatory monitoring clearly associated shorter survival. Sodium volume excess...
Renal dysfunction is a key risk factor for all-cause mortality in patients with type 2 diabetes (T2D). Circulating tumor necrosis receptor 1 (TNFR1) was recently suggested as strong biomarker end-stage renal failure T2D. However, its relevance regarding death has yet to be conclusively established. We aimed assess the prognostic value of serum TNFR1 concentration T2D and diabetic kidney disease (DKD) from SURDIAGENE (Survie, Diabete de et Genetique) study.A total 522 DKD (estimated...
Autoimmune thrombotic thrombocytopenic purpura (TTP) can be associated with other autoimmune disorders, but their prevalence following TTP remains unknown. To assess the of disorders and to determine risk factors for time course development an disorder after a episode, we performed cross sectional study. Two-hundred sixty-one cases were included in French Reference Center registry between October, 2000 May, 2009. Clinical laboratory data available at diagnosis recovered. Each center was...