A5056641569- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Mosquito-borne diseases and control
- Healthcare Systems and Practices
- Travel-related health issues
- HIV, Drug Use, Sexual Risk
- Prenatal Substance Exposure Effects
- Cannabis and Cannabinoid Research
- Gestational Diabetes Research and Management
- Substance Abuse Treatment and Outcomes
- Nutrition and Health in Aging
- Climate Change and Health Impacts
- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Vectors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Posttraumatic Stress Disorder Research
- Hepatitis Viruses Studies and Epidemiology
- Alcohol Consumption and Health Effects
- Homelessness and Social Issues
- Health, Medicine and Society
- Viral-associated cancers and disorders
- Adolescent Sexual and Reproductive Health
- Hepatitis C virus research
Inserm
2003-2024
Peuplements végétaux et bioagresseurs en milieu tropical
2018-2024
Centre Hospitalier Universitaire de La Réunion
2021-2024
Écologie Marine Tropicale des Océans Pacifique et Indien
2024
Centre d’histoire de Sciences Po
2016-2023
Santé Publique France
2013-2021
Economic & Social Sciences, Health Systems & Medical Informatics
2014-2021
Aix-Marseille Université
2014-2021
Institut de Recherche pour le Développement
2014-2021
Clinical Investigation Center Plurithematic Tours
2021
Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and albopictus. After half a century of focal outbreaks acute febrile polyarthralgia in Africa Asia, the disease unexpectedly spread past decade with large around Indian Ocean rare autochthonous transmission temperate areas. This emergence brought new insights on its pathogenesis, notably role A226V mutation that improved CHIKV fitness Ae. albopictus possible persistence deep tissue sanctuaries for...
Since 2003, the tropical arthritogenic chikungunya (CHIK) virus has become an increasingly medical and economic burden in affected areas as it can often result long-term disabilities. The clinical spectrum of post-CHIK (pCHIK) rheumatic disorders is wide. Evidence-based recommendations are needed to help physicians manage treatment afflicted patients.We conducted a 6-year case series retrospective study Reunion Island patients referred rheumatologist due continuous or musculoskeletal pains...
We compared the morbidity and quality of life military policemen ("gendarmes") infected with chikungunya virus (CHIKV+) 30 months after contamination. categorized subjects in 3 groups: healed patients (n = 48), non-healed 37, 44% CHIKV+), uninfected (CHIKV-, n 297). Data were self-recorded this retrospective cohort study; they included sociodemographic information, clinical symptoms, Medical Outcome Study 36-item short-form health survey (MOS-SF36) questionnaire. The study population was...
Clinical trials of direct oral anticoagulants (DOAC) are scarce and inconclusive in patients who receiving dialysis, for whom DOAC not labelled Europe. In a French nationwide registry study on chronic we compared the effectiveness safety off-label use vs approved vitamin K antagonist (VKA).
The objective of this study was to estimate the prevalence and risk factors for clinical lipodystrophy (LD) metabolic disorders in human immunodeficiency virus (HIV) type 1-infected patients. A cross-sectional survey Aquitaine Cohort performed January 1999. diagnosis LD categorized as fat wasting (FW), peripheral accumulation (FA), mixed syndromes (MS). Of 581 patients studied, 61% were treated with protease inhibitors. overall 38% (95% confidence interval [CI], 32–42): FW 16% CI, 13–18);...
Objective: To study hepatic cytolysis in patients treated by highly active antiretroviral therapy (HAART) with protease inhibitor or two nucleoside reverse transcriptase inhibitors (NRTIs). Methods: We selected of the Aquitaine Cohort who initiated HAART NRTIs before 1 January 1998, had alanine amino-transferase (ALT) ≤ 200 IU/l at baseline and least one follow-up measure. Cox model was used to association between occurrence severe (ALT>200 IU/l) age, gender, HIV transmission group, CD4 CD8...
The objective was to identify severity characteristics of initial chikungunya infection (CHIKV) stages associated with post-CHIKV arthritis and arthralgia. French gendarmes exposed the 2005–2006 CHIKV epidemic in Reunion Island who completed 2006 (self-reporting acute early chronic [median: 6 months] symptoms) 2008 (Endpoint 30 months]: self-perceived recovery rheumatic disorders (RDs)) surveys were included. Multinomial logistic regression multiple correspondence analysis (MCA) used....
Background Chikungunya virus (CHIKV), an arbovirus, is responsible for a two-stage disabling disease, consisting of acute febrile polyarthritis the first 10 days, frequently followed by chronic rheumatisms, sometimes lasting years. Up to now, pathophysiology stage has been elusive. Considering existence occasional peripheral vascular disorders and some unexpected seronegativity during we hypothesized role cryoglobulins. Methods From April 2005 May 2007, all travelers with suspected CHIKV...
Malaria chemoprophylaxis compliance is suboptimal among French soldiers despite the availability of free malaria and repeated health education before, during after deployment to endemic areas. In 2007, a randomized controlled study was performed cohort returning from Côte d'Ivoire assess feasibility acceptability sending daily short message service (SMS) reminder via mobile device remind take their chemoprophylaxis, impact SMS on compliance. consisted dose 100 mg doxycycline monohydrate,...
Background Clinical guidelines for the prevention of opportunistic infections in human immunodeficiency virus (HIV)-infected individuals have been developed on basis natural history data collected USA. The objective this study was to estimate incidence primary HIV-infected geographically distinct cohorts France.
To investigate employment levels and identify barriers to work among persons living with HIV/AIDS in France 2001, we conducted a cross-sectional study HIV-infected patients seen the hospital outpatient clinics of two French regions most affected: Ile-de-France (IDF) Provence–Alpes–Côte-d'Azur (PACA). Of 840 outpatients included study, 58.8% IDF 46.8% PACA were currently employed, 28.1 47.8%, respectively, receiving disability benefits. Among unemployed patients, 32.1% 29.6% reported that...
To describe the recent evolution of antiretroviral prescriptions and to look for clinical biological changes among a population HIV-infected patients.Patients received follow-up in hospital-based information system Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA), Southwestern France, from 1995 1997.Quarterly treatments indicators were studied this observational survey computerized records obtained after each hospital contact.Overall numbers patients who contacts remained stable....
The prognosis for survival of patients infected with the human immunodeficiency virus (HIV) who develop non-Hodgkin lymphoma (NHL) usually is considered to be poor. To authors' knowledge impact highly active antiretroviral therapy, recently introduced in HIV disease case management, has not yet been studied such circumstances.All cases NHL prospectively diagnosed between January 1986 and December 1997 among followed Aquitaine Cohort were reviewed. Kaplan-Meier method proportional hazards...
Based on national level surveys, we examined data relevant to the United States' overall effort prevent spread of HIV among heterosexual adults. We changes in condom use at-risk heterosexuals over past decade. The observed increases time across all population segments are consistent with (declines) trends and syphilis 1990s. These results findings from prior studies suggest that U.S. efforts facilitate contain related sexually transmitted disease (STD)cofactors adult at risk was succeeding...
Objective: To describe the clinical and biologic evolution of HIV-1 infection in Africa. Methods: One hundred four HIV-1-infected individuals were identified prospectively from regular blood donors Abidjan, Côte d’Ivoire. The date seroconversion was estimated results sequential serologic tests. Biologic followup performed every 6 months, starting as early possible after seroconversion. Case management followed national guidelines. Results: median interval between study inclusion 9.7 window...
The aim of the current study is to describe consumption rate alcohol, tobacco, and cannabis in French Army. A cross-sectional two strata randomized survey was performed between October 2006 March 2007 using self-report questionnaires (n = 990) collect individual characteristics, consumption, addictive behaviors with urinal tests for 985). surveyed sample comprised 59% privates, 26% non-commissioned officers, 6% predominantly male (89%) young (median age: 29 years), had a low level education...
This study assesses, for the first time, incidence, etiology, and determinants associated with traveler's diarrhea (TD) among French forces deployed to N'Djamena, Chad.A prospective was conducted based on physician consultation during a 5-month mandate. Diarrhea defined as ≥3 loose stools in 24-hour period or ≥2 within last 8 hours. For each diarrheic episode, an anonymous physician-administered questionnaire completed stool sample collected. Samples were tested parasites, bacteria, enteric...
Malaria is a public health concern in the French armed forces, with 400–800 cases reported every year and three deaths past 2 years. However, lack of chemoprophylaxis (CP) compliance often among service members. The aim this study was to explore factors associated CP compliance. A retrospective (1296 members) carried out troops deployed Central African Republic. Determinants were collected by self-questionnaire. Socio-demographic variables, behavioural characteristics, belief operational...
The aims were to evaluate the accuracy of self-report past-month cannabis use in a representative sample French military staff members and scale prevarication bias.Data from three cross-sectional surveys conducted between 2005 2008 (n = 3493) used. characteristics (sensitivity, specificity, positive predictive value negative value) computed using tetrahydrocannabinol detection urine as reference.The prevalence for was 16.1% testing 13.4%. discriminant power good, with an area under receiver...
Self-reporting seems more appropriate than medical-based surveillance to estimate true incidence of diarrhea during deployment military troops. Most soldiers self-reported multiple episodes, 42% leading medical care, mainly the first episode, resulting in a threefold higher incidence. Mathematical models integrating data should better predict outbreaks deployments and define complete assessment disease burden.