A5053522082- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- HIV Research and Treatment
- Dengue and Mosquito Control Research
- Vector-Borne Animal Diseases
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Parvovirus B19 Infection Studies
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Viral Infections and Immunology Research
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- Lymphoma Diagnosis and Treatment
- Fire effects on ecosystems
- Travel-related health issues
- HIV/AIDS Research and Interventions
- Plant Virus Research Studies
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Histiocytic Disorders and Treatments
Institut Pasteur du Laos
2014-2023
Ministry of Health
2022
Institut Pasteur
2008-2021
Université Paris Cité
2021
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit
2018
Hôpital Laveran
2007-2016
Institut de Médecine Tropicale du Service de Santé des Armées
2004-2013
Department of Virology
2013
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2012
Laboratoire National de Référence
2012
Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV was addressed prospective cohort study 49 hospitalized patients from Reunion Island subsequently categorized into two distinct groups at 12 mo postinfection. Comprehensive analyses the clinical and immunological parameters throughout disease course...
In September 2010, two cases of autochthonous dengue fever were diagnosed in metropolitan France for the first time. The occurring Nice, southeast France, where Aedes albopictus is established, are evidence virus circulation this area. This local transmission calls further enhanced surveillance, active case finding and vector control measures to reduce spread risk an epidemic.
In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis viral genomes imported and isolates indicated new features for potential emergence spread Europe.
A large chikungunya virus (CHIKV) outbreak emerged in 2005-2006 the Indian Ocean islands, including Comoros, Mayotte, Mauritius, Seychelles, and particularly Reunion Island where 35% of 770,000 inhabitants were infected 6 months. More recently, circulation has been documented Madagascar India CHIKV is spreading rapidly. CHIKV-infected visitors have returned home to nonendemic regions from these islands. We conducted a 14-month prospective observational study on clinical aspects infection...
Chikungunya virus (CHIKV) is a recently reemerged arbovirus responsible for massive outbreak of infection in the Indian Ocean region and India that has very significant potential to spread globally because worldwide distribution its mosquito vectors. CHIKV induces usually self-limited disease humans characterized by fever, arthralgia, myalgia, rash; however, cases severe have been described, particularly adults with underlying condition neonates born viremic mothers.
Background Since 2005, cases of chikungunya (CHIK) were caused by an unusual vector, Aedes albopictus. This mosquito, present in Europe since 1979, has gained importance its involvement the first CHIK outbreak Italy 2007. The species is capable transmitting experimentally 26 arboviruses. However, vectorial status temperate populations remained little investigated. In 2010, autochthonous and dengue (DEN) reported southeastern France. We evaluated potential a French population Ae. albopictus...
To identify the mosquito species able to sustain transmission of West Nile Virus (WNV) in Camargue region (the main WNV focus southern France), we assessed vector competence Culex modestus and pipiens, most abundant bird-feeders, Aedes caspius, mammophilic occasionally found engorged with avian blood. Female mosquitoes were exposed infectious meal (10(10.3) plaque forming units (PFU)/mL) by membrane feeding, hold at 26 degrees C. After incubation period, disseminated infection was detection...
Chikungunya virus (CHIKV) is transmitted to humans through the bite of Aedes mosquitoes. During 2005–2006 epidemic that occurred in Indian Ocean Islands, a viral strain harboring substitution an alanine valine at position 226 (E1-A226V) E1 glycoprotein enhanced transmissibility CHIKV by albopictus. In March 2011, autochthonous transmission was reported New Caledonia (NC), island located southwest Pacific Ocean. This first report local chikungunya (CHIK) this region world. Phylogenetic...
Abstract We report the isolation of chikungunya virus from a patient during an outbreak denguelike syndrome in Cameroon 2006. The was phylogenetically grouped Democratic Republic Congo cluster, indicating continuous circulation genetically similar population 6 years Central Africa.
The primary vector at the origin of 2007 outbreak in Libreville, Gabon is identified as Aedes albopictus, trapped around nearby French military camp. Chikungunya virus was isolated from mosquitoes and found to be identical A226V circulating human strain. This first field study showing role recently arrived species albopictus transmission Central Africa, it demonstrates this species' modifying epidemiological presentation Gabon.
Chikungunya virus (CHIKV) is an alphavirus responsible for numerous epidemics in Africa and Asia. Infection by CHIKV often characterized long-lasting, incapacitating arthritis, some fatal cases have been described among elderly newborns. Currently, there no available vaccine or specific treatment against CHIKV. Blood B cells from a donor with history of infection were activated, immortalized, amplified, cloned. Two human mAbs CHIKV, 5F10 8B10, identified, sequenced, expressed recombinant...
Background. Chikungunya virus (CHIKV) is an arbovirus with a high potential to spread globally. We investigated whether CHIKV transmittable via corneal grafts.
Jingmenvirus is a recently identified group of segmented RNA viruses phylogenetically linked with unsegmented Flaviviridae viruses. Primarily in various tick genera originating China, geographical distribution has rapidly expanded to cover Africa, South America, Caribbean, and Europe. The identification Jingmen-related mammals, including febrile humans, opens the possibility that Jingmenviruses may be novel tick-borne arboviruses. In this study, we aimed at increasing knowledge host range,...
The epidemiologic link between multicentric Castleman's disease (MCD) and Kaposi's sarcoma (KS) the high frequency of KS herpesvirus (KSHV) detection in both diseases raise question a role this new virus pathogenesis MCD. To explore hypothesis, KSHV DNA load was investigated peripheral blood mononuclear cells 3 human immunodeficiency (HlV)—infected patients with MCD at different points during clinical course. Clinical parameters, such as fever presence lymphadenopathy, were systematically...
Sporadic cases of acute hepatitis E among ten native Nigerian adults were reported in Port-Harcourt (Nigeria). Hepatitis virus (HEV) was detected serum and/or faecal samples seven patients by RT–PCR the open reading frame (ORF)-1 polymerase region and 3′-end ORF2. Restriction analysis widely used to distinguish genotypes I III showed that all strains have a pattern similar Mexican strain (NotI, nt 286; SmaI, 397; no KpnI restriction site) but displayed BsmI site at 213 as do most African HEV...
Abstract This study reports the first isolation and partial genetic characterization of Chikungunya virus (CHIKV) from patients during a 2006–2007 dengue‐like syndrome outbreak in Gabon. The isolated viruses were phylogenetically close to strains Democratic Republic Congo 7 years ago more recently Cameroon. These results indicate continuing circulation genetically stable CHIKV population Central Africa. J. Med. Virol. 80:430–433, 2008. © 2008 Wiley‐Liss, Inc.
The development and validation of a one-step, single-tube, real-time accelerated reverse-transcription loop-mediated isothermal amplification (RT-LAMP) for the detection L RNA segment Rift Valley fever virus (RVFV) are described. assay was performed at constant temperature (63 degrees C), with follow-up using LightCycler double-stranded-DNA-intercalating fluorochrome. is highly sensitive comparable to RT-PCR, limit approximately 10 copies per assay. However, RT-LAMP much faster than...
Chikungunya fever is a mosquito-borne disease of key public health importance in tropical and subtropical countries. Although severe joint pain the most distinguishing feature chikungunya fever, diagnosis remains difficult because symptoms are shared by many pathogens, including dengue fever. The present study aimed to develop new immunochromatographic test for detection virus antigen serum. Mice were immunized with isolates from patients Thai East/Central/South African genotype, produce...
Background Dengue is not well documented in Africa. In Cameroon, data are scarce, but dengue infection has been confirmed humans. We conducted a study to document risk factors associated with anti-dengue virus Immunoglobulin G seropositivity humans three major towns Cameroon. Methodology/Principal Findings A cross sectional survey was Douala, Garoua and Yaounde, using random cluster sampling design. Participants underwent standardized interview were blood sampled. Environmental housing...
Mayaro virus (MAYV) disease is a mosquito-borne zoonosis endemic in humid forests of tropical South America. MAYV closely related to other alphaviruses that produce dengue-like illness accompanied by long-lasting arthralgia. A French tourist developed high-grade fever and severe joint manifestations following 15-day trip the Amazon basin, Brazil, was diagnosed with infection January 2010. This case first reported traveller returning from an American country Europe.