A5028934517- Complement system in diseases
- Mosquito-borne diseases and control
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Vectors
- Blood Coagulation and Thrombosis Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- Viral Infections and Outbreaks Research
- Autoimmune and Inflammatory Disorders Research
- interferon and immune responses
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Alzheimer's disease research and treatments
- Malaria Research and Control
- Leptospirosis research and findings
- Peripheral Neuropathies and Disorders
- Inflammation biomarkers and pathways
- S100 Proteins and Annexins
- Barrier Structure and Function Studies
- Extracellular vesicles in disease
- Bacterial Infections and Vaccines
- HIV Research and Treatment
- Immune cells in cancer
- Apelin-related biomedical research
- Axon Guidance and Neuronal Signaling
Centre Hospitalier Universitaire de La Réunion
2016-2025
Écologie Marine Tropicale des Océans Pacifique et Indien
2010-2023
Observatoire des Sciences de l'Univers de la Réunion
2008-2022
Pharmac
2020-2021
Peuplements végétaux et bioagresseurs en milieu tropical
2009-2021
Centro de Salud Casa del Barco
2021
Inserm
1992-2019
Processus Infectieux en Milieu Insulaire Tropical
2015-2019
Centre National de la Recherche Scientifique
2016-2019
Institut de Recherche pour le Développement
2016-2019
Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV was addressed prospective cohort study 49 hospitalized patients from Reunion Island subsequently categorized into two distinct groups at 12 mo postinfection. Comprehensive analyses the clinical and immunological parameters throughout disease course...
Abstract C biosynthesis at extrahepatic sites remote from plasma may be important in the protection of tissues against inflammation and infection but also contribute to tissue injury. This latter possibility is particularly relevant central nervous system (CNS), where several cell types are susceptible damage by C. We have previously shown that human astrocyte-derived tumor lines synthesize secrete all components activation pathways In this study, we demonstrate these cells produce (C6, C7,...
C3a and C5a anaphylatoxins are cytokine-like polypeptides generated during complement (C) system activation released at the inflammatory site. They exert several biological activities through binding to G-protein-coupled receptors C3aR C5aR, respectively. Cloning Northern blot experiments have indicated that both expressed by myeloid as well nonmyeloid cells (e.g., endothelial epithelial cells). To better understand roles of C inflammation, we investigated their effects on expression...
Abstract The complement anaphylatoxins C5a and C3a are released at the inflammatory site, where they contribute to recruitment activation of leukocytes resident cells. distribution receptor for (C5aR) has been well studied; however, (C3aR) only recently cloned, its is uncharacterized. Using a specific affinity-purified anti-C3aR peptide Ab oligonucleotides reverse transcriptase-PCR analysis, C3aR expression was characterized in vitro on myeloid nonmyeloid cells vivo brain. expressed by adult...
Chikungunya virus (CHIKV) surprised medical workers by a massive outbreak in the Indian Ocean region, reaching Europe 2007, with exceptional pathologies infants and elderly patients. Although CHIKV was recently shown to persist myoblasts, monocytes, macrophages, we argued that robust antiviral mechanisms, including apoptosis, are essential ward off virus. Herein, tested capacity of mobilize apoptotic machinery HeLa cells as well primary fibroblasts, making use several inhibitors caspases,...
The C fragment C5a exerts its important physiologic and pathologic effects through interaction with a specific receptor (C5aR) which is highly expressed on polymorphonuclear leukocytes some other leukocytes. presence of this epithelia endothelia has recently been documented, raising the possibility that these cells might also respond to locally generated C5a. implicated in several brain disorders, notably demyelination neurodegeneration, within can synthesize complete system. It thus...