A5004842117- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Dermatological and COVID-19 studies
- HIV-related health complications and treatments
- Autoimmune Bullous Skin Diseases
- Eosinophilic Disorders and Syndromes
- Leprosy Research and Treatment
- Cutaneous lymphoproliferative disorders research
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Cancer and Skin Lesions
- Mast cells and histamine
- Autoimmune and Inflammatory Disorders Research
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Kawasaki Disease and Coronary Complications
- Skin Diseases and Diabetes
- Drug-Induced Adverse Reactions
Université Paris Cité
2020-2024
Assistance Publique – Hôpitaux de Paris
2006-2024
Centre Hospitalier René-Dubos
2012-2023
Centre hospitalier régional d'Orléans
2023
Hôpital Louis-Mourier
2020
Inserm
2020
Agroécologie
2016
Institut de Recherche en Santé, Environnement et Travail
2012
Générale de Santé
2006-2009
Sorbonne Université
1993-2005
To evaluate the clinical and biological impact of protease inhibitors on HIV-associated Kaposi's sarcoma.A cohort 10 patients included prospectively from April 1996 to June 1997 were studied in one institutional centre after initiation inhibitors.All but (stable disease) had progressive sarcoma. Three out stopped specific chemotherapy for sarcoma more than 4 weeks, three still under chemotherapy, four never received treatment Plasma HIV viral load, human herpesvirus (HHV)-8 viraemia...
The epidemiologic link between multicentric Castleman's disease (MCD) and Kaposi's sarcoma (KS) the high frequency of KS herpesvirus (KSHV) detection in both diseases raise question a role this new virus pathogenesis MCD. To explore hypothesis, KSHV DNA load was investigated peripheral blood mononuclear cells 3 human immunodeficiency (HlV)—infected patients with MCD at different points during clinical course. Clinical parameters, such as fever presence lymphadenopathy, were systematically...
We retrospectively reviewed 5 cases of hemophagocytic lymphohistiocytosis (HL) associated with human herpesvirus 8 (HHV-8) reactivation in immunodeficiency virus (HIV)-infected patients. All patients had clinical and biological features characteristic HL. Pulmonary symptoms were present all frequently life threatening. The mean number HL episodes was 6. Four HL-associated Kaposi sarcoma, 3 multicentric Castleman disease. CD4 cell count 200 cells/mm(3). HIV loads stable high levels HHV-8...
Serum sex hormone-binding globulin (SHBG), testosterone, non-SHBG-bound androstenedione, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), follicle-stimulating hormone (FSH), luteinizing (LH) and cortisol were measured in 58 homosexual men seropositive for human immunodeficiency virus (HIV), all clinically asymptomatic (Centers Disease Control 1993 classification stage A). The HIV patients divided into four groups according to the CD4 lymphocyte count--group 1 (more than...
BackgroundInterpretation of the increase in certain inflammatory markers virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We compared profiles participants under long-term antiretroviral therapy (ART) with those two HIV-uninfected groups contrasting health behaviours.MethodsWe studied 150 (42 women, 108...
In 28 fetuses studied during a 4 1/2-year period, the initial femur was below 2 standard deviations (SDs) of mean when compared with biparietal diameter. These were considered at risk for skeletal dysplasias and followed up. Studies performed gestational age 26.7 weeks (range, 15.3-41.0 weeks). Group 1 had length 1-4 mm 2-SDs line -2.0 to -4.0 SDs); no other abnormalities detected. Interval examination 12 femurs showed that 10 either remained shortened same degree or growth spurt. At birth,...
Progressive multifocal leukoencephalopathy occurred in two homosexual men affected with acquired immune deficiency syndrome (AIDS). Both patients received HLA-matched platelet transfusions an attempt to increase their status, but we were unsuccessful altering fatal clinical course.
New options for first-line treatment of human immunodeficiency virus type 2 (HIV-2) infection are needed. We evaluated an integrase inhibitor (raltegravir)–containing regimen. Antiretroviral therapy (ART)–naive adults with symptomatic by HIV-2 only, CD4 count <500 cells/μL or decrease >50 cells/μL/year over the past 3 years, a confirmed plasma RNA (pVL) load ≥100 copies/mL were eligible this noncomparative trial. The composite primary endpoint was survival at 48 weeks without any following:...
Abstract Objectives Despite the effectiveness of antiretroviral (ARV) therapy to control HIV infection, HIV-associated neurocognitive disorders (HAND) remain frequent. The Neuro+3 study assessed cognitive improvement associated with ARV intensification based on increased CNS penetration (CPE) scoring ≥+3 and total CPE score ≥9. Methods Thirty-one patients, aged 18–65 years, confirmed diagnosis HAND effective were included. was measured using Frascati three-stage classification global deficit...