A5028418709- Hepatitis Viruses Studies and Epidemiology
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Hepatitis C virus research
- Antibiotic Resistance in Bacteria
- Liver Disease and Transplantation
- Mycobacterium research and diagnosis
- Health, Medicine and Society
- Antibiotic Use and Resistance
- Healthcare Systems and Practices
- Zoonotic diseases and public health
- Vaccine Coverage and Hesitancy
- Vibrio bacteria research studies
- Tuberculosis Research and Epidemiology
- Travel-related health issues
- Salmonella and Campylobacter epidemiology
- Liver Disease Diagnosis and Treatment
- Burkholderia infections and melioidosis
- Diphtheria, Corynebacterium, and Tetanus
- Veterinary medicine and infectious diseases
- Parasites and Host Interactions
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Child Nutrition and Water Access
- Yersinia bacterium, plague, ectoparasites research
Académie Nationale de Médecine
2007-2024
Sorbonne Université
2016-2023
Centenary Institute
2023
Institut de Médecine Tropicale du Service de Santé des Armées
2005-2019
Centre Hospitalier Régional Universitaire de Brest
2019
Centre d’Infectiologie Christophe Mérieux of Laos
2009-2018
Institut Pasteur
2002-2018
Pitié-Salpêtrière Hospital
2016-2018
Agence de Médecine Préventive
2018
Société Française de Cardiologie
2018
Over a 3-year follow-up, 30 out of the 318 unique Mycobacterium tuberculosis complex isolates recovered in Republic Djibouti had smooth-type morphology and were Niacine-negative, characteristics 'Mycobacterium canettii' strains. Unlike M. tuberculosis, 'M. grew on nutrient-poor media at 30°C, possessed characteristic lipids. They isolated from respiratory extra-respiratory sites patients with typical forms tuberculosis. Most cases resolved antibiotic therapy but two human immunodeficiency...
Abstract Background Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae have spread worldwide but there are few reports on carriage in hospitals low-income countries. ESBL-producing (ESBL-PE) been increasingly isolated from nosocomial infections Antananarivo, Madagascar. Methods we conducted a prevalence survey pediatric unit March to April 2008 Patient rectal swabs were sampled the first and last day of hospitalization. Medical staff environment also sampled. Rectal...
Background Extended-spectrum ß-lactamase-producing Enterobacteria (ESBL-PE) emerged at the end of 1980s, causing nosocomial outbreaks and/or hyperendemic situations in hospitals and long-term care facilities. In recent years, community-acquired infections due to ESBL-PE have spread worldwide, especially across developing countries including Madagascar. Objectives This study aimed determine prevalence risk factors intestinal carriage community Antananarivo. Methods Non-hospitalized patients...
Background The global burden of diarrhea is a leading cause morbidity and mortality worldwide. In montane areas South-East Asia such as northern Laos, recent changes in land use have induced increased runoff, soil erosion in-stream suspended sediment loads, potential pathogen dissemination. To our knowledge, few studies related incidences to catchment scale hydrological factors river discharge, loads Fecal Indicator Bacteria (FIB) Escherichia coli, together with sociological hygiene...
The epidemiologic link between multicentric Castleman's disease (MCD) and Kaposi's sarcoma (KS) the high frequency of KS herpesvirus (KSHV) detection in both diseases raise question a role this new virus pathogenesis MCD. To explore hypothesis, KSHV DNA load was investigated peripheral blood mononuclear cells 3 human immunodeficiency (HlV)—infected patients with MCD at different points during clinical course. Clinical parameters, such as fever presence lymphadenopathy, were systematically...
The aim of this study was to investigate the following in a large population French patients with chronic hepatitis C: geographical distribution C virus (HCV) genotypes; relationship between HCV genotypes and epidemiological characteristics; severity disease; response interferon (IFN) therapy. Data from 14 tertiary referral centres, corresponding 1872 C, were prospectively collected 1989 1997. genotyping performed using line probe assay (LiPA). 1b, 3, 1a, 2, 4 mixed infection found 41%, 22%,...
Sporadic cases of acute hepatitis E among ten native Nigerian adults were reported in Port-Harcourt (Nigeria). Hepatitis virus (HEV) was detected serum and/or faecal samples seven patients by RT–PCR the open reading frame (ORF)-1 polymerase region and 3′-end ORF2. Restriction analysis widely used to distinguish genotypes I III showed that all strains have a pattern similar Mexican strain (NotI, nt 286; SmaI, 397; no KpnI restriction site) but displayed BsmI site at 213 as do most African HEV...
Multiresistance to antibiotics including beta-lactams, e.g. cefoxitin, was transferred by conjugation Escherichia coli strain C1a from a clinical isolate of Salmonella senftenberg recovered stools an Algerian child. The susceptibility pattern beta-lactams similar the profile mediated AmpC-type beta-lactamase. By biochemical analysis, typical enzyme substrate and inhibition profiles were obtained. Finally, ampC plasmid-encoded beta-lactamase gene cloned sequenced. Its deduced amino acid...
Abstract Objectives Intestinal carriage constitutes an important reservoir of antimicrobial-resistant bacteria, with some the highest rates reported from Asia. Antibiotic resistance has been little studied in Laos, where antibiotics are available without restriction, but others such as carbapenems not available. Patients and methods We collected stools 397 healthy children 12 randomly selected pre-school childcare facilities around Vientiane. Colonization ESBL-producing Enterobacteriaceae...
To assess the antibiotic prescribing practices of doctors working in Lao People's Democratic Republic and their knowledge local resistance patterns.Doctors attending morning meetings 25 public hospitals four provinces were asked to complete a knowledge, attitude practice survey. The questionnaire contained 43 multiple choice questions that doctor answered at time meeting.The response rate was 83.4% (386/463). Two hundred seventy (59.8%) declared they had insufficient information about...
Background During late 2012 and early 2013 several outbreaks of diphthe-ria were notified in the North Lao People's Democratic Republic. The aim this study was to determine whether re-emergence vaccine-preventable disease due insufficient vaccination coverage or reduction vaccine effectiveness within affected regions. Methods A serosurvey conducted Huaphan Province on a cluster sampling 132 children aged 12–59 months. Serum samples, socio-demographic data, nutri-tional status history...
Melioidosis, a severe infection with the environmental bacterium Burkholderia pseudomallei, is being recognised increasingly frequently. What determines its uneven distribution within endemic areas poorly understood. We cultured soil from rice field in Laos for B. pseudomallei at different depths on 4 occasions over 13-month period. also measured physical and chemical parameters order to identify associated characteristics. Overall, 195 of 653 samples (29.7%) yielded pseudomallei. A higher...
The purpose of this study was to analyze partial nucleotide sequences and derived peptide hepatitis E virus (HEV) from two outbreaks in Africa (Chad 1983–1984; Algeria 1978–1980). A portion ORF3 the major ORF2 were amplified by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). PCR products sequenced directly or after cloning into pCRII vector. Sequences then compared corresponding regions reported full length HEV sequences. In regions, homology between Algerian Chad isolates at...
Hepatitis E virus (HEV) is a major enterically transmitted pathogen in many developing countries, where it causes outbreaks and sporadic cases of acute hepatitis. A study conducted with pigs from several livestock farms Cambodia identified one swine genotype 1 HEV isolate as being associated prevalent 3 HEV.
The genetic diversity of hepatitis E virus (HEV) has been extensively analysed during the last decade. Most sporadic and epidemic HEV strains are distributed into genotypes or groups. Nevertheless, few studies have looked at polymorphism isolated from a given outbreak. A serum bank collected in Tanefdour, Algeria, an acute (1986-1987), retrospectively confirmed as E, was analysed. Of 69 samples within 8-week period, 23 were positive for both partial ORF1 (replicase gene) ORF2 (capsid...
Cervical cancer is the first female in Lao PDR, a low-income country with no national screening and prevention programs for this human papillomavirus (HPV) associated pathology. HIV-infected women have higher risk of persistent oncogenic HPV infection.The purpose study was to determine knowledge, awareness attitudes about cervical among attending or not an HIV treatment center, order understand if attendance had offered opportunity information prevention.A cross-sectional case-control survey...
Despite hepatitis B vaccination at birth and 6, 10 14 weeks of age, virus (HBV) infection continues to be endemic in the Lao People's Democratic Republic (PDR). We carried out a cross-sectional serological study infants, pre-school children, school pupils pregnant women determine their burden disease, risk status. A total 2471 participants between 9 months 46 years old were recruited from urban (Vientiane Capital, Luang Prabang), semi-urban (Boulhikhamxai Savannakhet) remote rural areas...
Forty-one patients with acute or fulminant hepatitis and 86 control were entered into a study of sporadic, acute, in the N'Djamena area Chad 1993. Acute B was diagnosed nine (22%) E 27 (66%) patients. No A observed 10% had serologic markers C virus (HCV) infection. Dual four (10%) HEV infection associated chronic surface antigen carriage 16 (39%). Epidemiologic findings concerning HBV from suggest that these undiagnosed liver disease due to HBV, deterioration caused by superimposed...