A5060829081- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- COVID-19 epidemiological studies
- Animal Disease Management and Epidemiology
- COVID-19 Clinical Research Studies
- Congenital Diaphragmatic Hernia Studies
- Vaccine Coverage and Hesitancy
- Virology and Viral Diseases
- Cytomegalovirus and herpesvirus research
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
- Biosensors and Analytical Detection
- RNA and protein synthesis mechanisms
- Hepatitis C virus research
- Data-Driven Disease Surveillance
- Parvovirus B19 Infection Studies
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 diagnosis using AI
- Neonatal Respiratory Health Research
University of Milan
2016-2025
University of Pavia
2020-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
University of Genoa
2014-2022
Centro interuniversitario per la ricerca sull'influenza e le altre infezioni trasmissibili
2014-2022
Norges Røde Kors
2022
Peruvian University of Applied Sciences
2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020-2021
University of Insubria
2018
Department of Medical Sciences
2014
Since 2009 pandemic, international health authorities recommended monitoring severe and complicated cases of respiratory disease, that is, acute infection (SARI) distress syndrome (ARDS). We evaluated the proportion SARI/ARDS deaths due to influenza A(H1N1)pdm09 impact other viruses during pandemic postpandemic period (2009–2011) in northern Italy; additionally we searched for unknown those which diagnosis remained negative. 206 samples were collected from analyzed by real-time RT-PCR/PCR...
In the night of February 20, 2020, first case novel coronavirus disease (COVID-19) was confirmed in Lombardy Region, Italy. week that followed, experienced a very rapid increase number cases. We analyzed 5,830 laboratory-confirmed cases to provide epidemiological characterization COVID-19 outbreak Western Country. Epidemiological data were collected through standardized interviews and their close contacts. demographic backgrounds, dates symptom onset, clinical features, respiratory tract...
In the night of February 20, 2020, first epidemic novel coronavirus disease (COVID-19) outside Asia was uncovered by identification its patient in Lombardy region, Italy. following weeks, experienced a sudden increase number ascertained infections and strict measures were imposed to contain spread.We analyzed official records cases occurred characterize epidemiology SARS-CoV-2 during early phase outbreak. A line list laboratory-confirmed set up later retrospectively consolidated, using...
Abstract SARS-CoV-2 symptoms are non-specific and can range from asymptomatic presentation to severe pneumonia. Asymptomatic subjects carrying often remain undiagnosed it is still debated whether they develop immunoglobulins (Ig) how long persist. The aim of this study was investigate the development persistence antibodies against in infected by virus. This follow-up performed on 31 who presented a positive nasal swab or serology (Ig Spike-RBD) first part UNICORN (March 2020) aimed at...
We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is line the seasonality of EV-D68 was presumably stimulated by widespread reopening after COVID-19 lockdown. Most were identified September, but more are to be expected coming months. Reinforcement clinical awareness, diagnostic capacities surveillance urgently needed Europe.
Abstract Alongside vaccines, antiviral drugs are becoming an integral part of our response to the SARS‐CoV‐2 pandemic. Nirmatrelvir—an orally available inhibitor 3‐chymotrypsin‐like cysteine protease—has been shown reduce risk progression severe COVID‐19. However, impact nirmatrelvir treatment on development SARS‐CoV‐2‐specific adaptive immune responses is unknown. Here, by using mouse models infection, we show that administration blunts antibody and T cell responses. Accordingly, upon...
ABSTRACT Introduction Human respiratory syncytial virus (RSV) is one of the most frequent causes infections in children under 5 years age, but its socioeconomic impact and burden primary care settings still little studied. Methods During 2022/2023 winter season, 55 pediatricians from five Italian regions participated our community‐based study. They collected a nasal swab for RSV molecular test 650 patients age with acute (ARIs) performed baseline questionnaire. The clinical disease was...
Abstract Background Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age-distribution, and clinical presentations Europe from 2018-2023. Methods Aggregated data were requested ECDC National Focal Points for Surveillance European Non-Polio Enterovirus Network. Data included detection month, specimen type, age-group, presentation the ten most commonly reported types per year. Findings Twenty-eight...
Activated lymphocytes release nano-sized vesicles (exosomes) containing microRNAs that can be monitored in the bloodstream. We asked whether elicitation of immune responses is followed by lymphocyte-specific microRNAs. found that, upon activation vitro, human and mouse down-modulate intracellular miR-150 accumulate it exosomes. In vivo, levels increased significantly serum humans immunized with flu vaccines mice ovalbumin, this increase correlated elevation antibody titers. Immunization...
Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections worldwide. While historically RSV research has been focused on children, data infection in adults are limited. The goal this study was to establish the prevalence community-dwelling Italian and analyze its genetic variability during 2021/22 winter season.In cross-sectional study, random sample naso-/oropharyngeal specimens from symptomatic seeking for SARS-CoV-2 molecular testing between December 2021 March...
Respiratory syncytial virus (RSV) is a leading cause of hospitalisation and mortality in young children globally. The social distancing measures implemented against COVID-19 Lombardy (Italy) disrupted the typically seasonal RSV circulation during 2019-2021 caused substantially more hospitalisations 2021-2022. primary aim this study to quantify immunity gap-defined as increased proportion population naïve infection following relaxation restrictions Lombardy, which has been hypothesised be...
Since 1985, two antigenically distinct lineages of influenza B viruses (Victoria-like and Yamagata-like) have circulated globally. Trivalent seasonal vaccines contain circulating A strains but a single strain thus provide limited immunity against the lineage not included in vaccine. In this study, we describe characteristics that caused respiratory illness population Italy over 13 consecutive seasons virological surveillance, match between predominant vaccine lineage, each season.From 2004...
An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in December 2019 China and was declared a pandemic on 11.03.2020 by WHO. Italy is one the most afflicted Country this epidemic with 136,110 confirmed cases 16,654 deaths 9.4.2020 (at same date, Ministry Health reporting 143,626 cases). During these few months National Service have made great effort to cope increasing request intensive care beds all elective activities hospital been suspended. Data from...
2][3] This surveillance intends to overcome the limitations of traditional indicators, 4 such as number positive tests, which depends on test availability and indications, or COVID-19-related hospitalizations, occur weeks after spread SARS-CoV-2 do not include mild asymptomatic cases.This study evaluated association between load in urban wastewater indicators infection prevalence severity Milan, Italy.
Abstract Background Despite thousands of influenza cases annually recorded by surveillance systems around the globe, estimating transmission patterns seasonal is challenging. Methods We develop an age-structured mathematical model to analyze ten consecutive seasons (from 2010 2011 2019–2020) epidemiological and virological data reported Italian system. Results estimate that 18.4–29.3% infections are detected Influenza infection attack rate varied between 12.7 30.5% generally larger for...
Following the pandemic restrictions, epidemiology of respiratory syncytial virus (RSV) has changed, leading to intense hospitalization peaks. This study, conducted at multiple sites in Italy, aimed describe temporal dynamics two post-COVID-19 RSV epidemics. Additionally, circulating RSV-A and -B lineages were characterized compared those found 2018 2019. Respiratory specimens data collected from RSV-positive patients, both inpatients, outpatients, all ages three north-central Italy. To...
Abstract Echovirus 11 (E11) has gained attention owing to its association with severe neonatal infections. Due the limited data available, World Health Organization (WHO) considers public health risk general population be low. The present study investigated genetic variation and molecular evolution of E11 genomes collected from May December 2023. Whole genome sequencing (WGS) was performed for 16 strains. Phylogenetic analysis on WG showed how all Italian strains belonged genogroup D5,...
Between September and October 2018, an enterovirus D68 (EV-D68) outbreak occurred in patients hospitalised with severe acute respiratory infection northern Italy; 21 laboratory-confirmed cases were reported. Phylogenetic analysis revealed that 16/20 of the EV-D68 sequences belonged to a divergent group within sub-clade D1. Since its upsurge, has undergone rapid evolution emergence new viral variants, emphasising need for molecular surveillance include outpatients illness.