Ursula Morley
A5050603657- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- SARS-CoV-2 detection and testing
- Polyomavirus and related diseases
- Animal Disease Management and Epidemiology
- Infectious Encephalopathies and Encephalitis
- Biosensors and Analytical Detection
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Whipple's Disease and Interleukins
- Animal Virus Infections Studies
University College Dublin
2017-2024
Heinrich Heine University Düsseldorf
2018
Imperial College London
2018
Biocrates Life Sciences (Austria)
2018
St Thomas' Hospital
2018
Amsterdam UMC Location University of Amsterdam
2018
Hamad General Hospital
2018
University of Oxford
2018
We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is line the seasonality of EV-D68 was presumably stimulated by widespread reopening after COVID-19 lockdown. Most were identified September, but more are to be expected coming months. Reinforcement clinical awareness, diagnostic capacities surveillance urgently needed Europe.
SARS-CoV-2 RNA quantification in wastewater is an important tool for monitoring the prevalence of COVID-19 disease on a community scale which complements case-based surveillance systems. As novel variants concern (VOCs) emerge there also need to identify primary circulating community, accomplished date by sequencing clinical samples. Quantifying offers cost-effective means augment these efforts. In this study, N1 concentrations and daily loadings were determined compared data collected as...
Abstract Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Network (ENPEN) aimed to investigate the epidemiological genetic characteristics of EV-D68 its clinical impact during fall-winter season 2021–2022. From 19 countries, 58 institutes reported 10 481 (6.8%) EV-positive samples which 1004 (9.6%) were identified as (including 852 samples). Clinical data for 969 cases; 78.9% in children (0–5 years);...
In 2018, an upsurge in echovirus 30 (E30) infections was reported Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected 22 countries Europe during 2016-2018. Most cases affected persons 0-4 years age (29%) 25-34 (27%). Sequences were divided into 6 genetic clades (G1-G6). (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 displayed >2...
Abstract Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) human parechovirus (HPeV) infections. Its effectiveness depends critically on using appropriate sample types high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis sepsis clinical presentation can be extremely low. This study evaluated specificity currently used commercial in‐house diagnostic assays. Accurately quantified RNA transcript...
Enteroviruses (EVs) are associated with a broad spectrum of clinical presentation, including aseptic meningitis (AM), encephalitis, hand, foot and mouth disease, acute flaccid paralysis, myelitis. Epidemics occur sporadically increased cases AM in children. The present study describes the seroepidemiological analysis circulating EVs Ireland from 2005 to 2014 phylogenetic characterization echovirus 30 (E-30), enterovirus A71 (EV-A71), D68 (EV-D68). EV VP1 genotyping was applied viral isolates...
The Neuropathology of Human Parechovirus (HPeV) is not widely described due to the relatively recent discovery virus combined with a limited number autopsy case reports. We report an infant boy born at 38 weeks who, six days after birth, presented fever and severe neurological dysfunction. Type 3 (HPeV3) RNA was detected in his cerebrospinal fluid (CSF) blood. He died five initial presentation. Neuropathologic examination demonstrated multicystic encephalomalacia (ME). This confirms that...
Human parechoviruses (HPeVs), particularly type 3, can cause severe neurological disease and neonatal sepsis in infants. HPeV3 lacks the receptor-binding motif arginine-glycine aspartic acid (RGD), is proposed to use a different receptor associated with disease. In contrast, HPeV1, which contains RGD motif, mild Rapid characterization of presence/absence this essential for understanding their epidemiology differential profiles. Current HPeV typing assays are based on partial capsid genes...
Data on the neurodevelopment of children who experienced central nervous system (CNS) infections with enteroviruses (EV) or parechoviruses (hPeV) is scarce and mostly limited to follow up short-term outcomes.Parents presented between 2014 2019, underwent a lumbar puncture whose cerebrospinal fluid was polymerase chain reaction positive for EV hPeV, were asked complete care-giver-administered neurodevelopmental assessment tool (The Ages Stages Instrument [ASQ3]). Clinical data infective...