A5016508902- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Cervical Cancer and HPV Research
- Herpesvirus Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- Reproductive tract infections research
- Molecular Biology Techniques and Applications
- Mycobacterium research and diagnosis
- HIV/AIDS drug development and treatment
- Immunodeficiency and Autoimmune Disorders
- Blood groups and transfusion
- Liver Disease and Transplantation
- Global Cancer Incidence and Screening
- Viral Infections and Immunology Research
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Toxoplasma gondii Research Studies
Université d'Angers
2012-2024
Centre Hospitalier Universitaire d'Angers
2014-2024
Sciences, Philosophie, Histoire
2023
Nantes Université
2023
methodS in Patient-centered outcomes and HEalth ResEarch
2023
University of Oxford
2021
Université Nantes Angers Le Mans
2015-2021
Université Bretagne Loire
2018
Department of Virology
2018
Institut de Virologie
2007-2014
Cytomegalovirus (CMV) drug resistance is a therapeutic challenge in the transplant setting. No longitudinal cohort studies of CMV real-life setting have been published valganciclovir era. We report findings for French multicentre prospective 346 patients enrolled at initial diagnosis infection (clinical trial registered clinicaltrials.gov: NCT01008540). Patients were monitored detection ≥2 years. Real-time by UL97 and UL54 gene sequencing antiviral phenotyping was performed if viral...
We aimed to investigate the first Omicron cases detected in France order assess case characteristics and provide supporting information on possible impact of this variant healthcare system. A standardized questionnaire was used collect from confirmed probable cases. Median age 468 investigated 35 years, 376 were symptomatic (89%); 64% vaccinated with two doses 7% had received three doses. Loss smell taste reported by 8.3% 9% cases, respectively. Seven hospitalized, those unvaccinated...
Humoral response against sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after two doses of BNT162b2 (Pfizer-BioNTech) has been proven to be less intense in maintenance dialysis patients as compared with healthy subjects, leading the French authorities recommend a third injection this population. Here we investigated cohorts haemodialysis (HD) patients.Data from prospective observational were collected. In first ('systematic') cohort, HD centres (n = 66) received BNT162b2,...
Abstract Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Network (ENPEN) aimed to investigate the epidemiological genetic characteristics of EV-D68 its clinical impact during fall-winter season 2021–2022. From 19 countries, 58 institutes reported 10 481 (6.8%) EV-positive samples which 1004 (9.6%) were identified as (including 852 samples). Clinical data for 969 cases; 78.9% in children (0–5 years);...
Abstract No recent data are available on hepatitis B virus (HBV) and Delta (HDV) prevalence in Mauritania. One thousand twenty pregnant women 946 patients visiting for routine checkups were screened HBV HDV infection. Demographic, epidemiological, ethnic, clinical, biological recorded. genotypes determined by sequencing phylogenetic analyses. In the cohorts, respectively, of HBsAg (10.7% 18.3%) anti‐HBcAb (66.3% 76.5%) indicated high endemicity. women, exposure to was significantly...
BackgroundA program, supported by the GEMHEP (Groupe d'étude Moléculaire des Hépatites), was established in 2007 sanitary district of Tokombéré, to prevent perinatal transmission hepatitis B virus (HBV). It comprises screening for HBV surface antigen (HBsAg) all pregnant women and vaccinating newborn if tests are positive. Methods/Principal Findings1276 were enrolled study after providing informed consent. Demographic data blood samples available 1267 patients. HBsAg determined locally using...
ABSTRACT During the last decade, growing efforts have focused on human papillomavirus (HPV) detection using liquid hybridization, conventional PCR, and real-time PCR-based methods to increase overall proportion of patients participating in cervical cancer screening procedures. We proposed a new general HPV DNA PCR Mx4000 (Stratagene) LightCycler (Roche Diagnostics) systems usable for both scrape specimens urine samples. A linear range was obtained from 5 copies 8 log 10 copies/ml, intra-...
SARS-CoV-2 coronavirus infection induces heterogeneous symptoms, ranging from asymptomatic to lethal forms. Severe forms usually occur in the elderly and/or individuals with comorbidities. Children generally remain primary infection, suggesting that they may have an effective local innate immune response. IFN-I and -III non-redundant protective roles against SARS-CoV-2, although sometimes damaging host. The expression role of anti-viral peptides during thus far been little studied. We aimed...
Abstract Aims Our main objective was to improve non‐invasive fibrosis staging accuracy by resolving the limits of previous methods via new test combinations. secondary objectives were precision, developing a detailed classification, and reliability (personalized accuracy) determination. Methods All patients (729) included in derivation population had chronic hepatitis C, liver biopsy, 6 blood tests Fibroscan. Validation populations 1584 patients. Results The most accurate combination...
Recent data have outlined a link between hypogammaglobulinemia (HGG) and infection risk suggested that HGG correction may decrease post-transplant infections.We analyzed the factors of relationship severe in cohort 318 kidney transplant recipients (KTR) who were transplanted 2003 2013. Immunoglobulin (Ig) concentration was measured prospectively at day 15 (D15), month 6 (M6), 12 (M12), 24 (M24) post transplant.The prevalence IgG 56% 36.8% D15 M6, respectively. Age sole identified for (odds...
International guidelines suggest combining a blood test and liver stiffness measurement (LSM) to stage fibrosis in chronic hepatitis C (CHC) non-alcoholic fatty disease (NAFLD). Therefore, we compared the accuracies of these tests between main etiologies diseases.Overall, 1968 patients were included 5 etiologies: CHC: 698, B: 152, human immunodeficiency virus/CHC: 628, NAFLD: 225, alcoholic (ALD): 265. Sixteen [13 tests, LSM (Fibroscan), 2 combined: FibroMeters] evaluated. References Metavir...
We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C II III I, suggesting that these specific residues are not involved enzymatic functions.