A5000648027- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- SARS-CoV-2 detection and testing
- Disaster Response and Management
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Bacillus and Francisella bacterial research
- Viral Infections and Vectors
- Clostridium difficile and Clostridium perfringens research
- Bacterial Infections and Vaccines
- COVID-19 epidemiological studies
- Syphilis Diagnosis and Treatment
- Biosensors and Analytical Detection
- Hepatitis B Virus Studies
- Bacterial Identification and Susceptibility Testing
- Salmonella and Campylobacter epidemiology
- Immune responses and vaccinations
- COVID-19 diagnosis using AI
- Burkholderia infections and melioidosis
- Mycobacterium research and diagnosis
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Diphtheria, Corynebacterium, and Tetanus
- Reproductive tract infections research
- Brucella: diagnosis, epidemiology, treatment
Santé Publique France
2022-2025
Institut thématique Santé Publique
2022-2025
Austrian Agency for Health and Food Safety
2020-2022
European Centre for Disease Prevention and Control
2020-2022
Medical University of Vienna
2022
Paracelsus Medical University
2022
University of Salzburg
2022
BOKU University
2022
Ames Research Center
2022
Centre International de Recherche en Infectiologie
2017-2021
Background Early detection and characterisation of SARS-CoV-2 variants have been continue to be essential for assessing their public health impact. In August 2023, Santé publique France implemented enhanced surveillance BA.2.86 sub-lineage JN.1 because genetic divergence from other increased prevalence. Aim To detail how combining epidemiological laboratory data sources, targeted investigations modelling enabled comprehensive JN.1. Methods Data were collected using a standardised...
We aimed to investigate the first Omicron cases detected in France order assess case characteristics and provide supporting information on possible impact of this variant healthcare system. A standardized questionnaire was used collect from confirmed probable cases. Median age 468 investigated 35 years, 376 were symptomatic (89%); 64% vaccinated with two doses 7% had received three doses. Loss smell taste reported by 8.3% 9% cases, respectively. Seven hospitalized, those unvaccinated...
BackgroundA rapid increase in incidence of the SARS-CoV-2 Omicron variant (sub-lineage BA.1) occurred France December 2021, while Delta was prevailing since July 2021. We aimed to determine whether risk a severe hospital event following symptomatic infection differs for versus Delta.MethodsWe conducted retrospective cohort study compare events (admission intensive care unit or death) between and cases matched according week virological diagnosis age. The analysis adjusted age, sex,...
Lassa fever is a major threat in Western Africa. The large number of people living at risk for this disease calls the development vaccine against virus (LASV). We generated live-attenuated LASV vaccines based on measles and Mopeia platforms expressing different antigens, with aim to develop able protect after single shot. compared efficacy these cynomolgus monkeys. were well tolerated protected animals from infection immunization but varying efficacy. Analysis immune responses showed that...
BACKGROUND. The pathogenesis of Ebola virus (EBOV) disease (EVD) is poorly characterized. establishment well-equipped diagnostic laboratories close to treatment centers (ETCs) has made it possible obtain relevant virological and biological data during the course EVD assess their association with clinical different outcomes disease. METHODS. We were responsible for diagnosing EBOV infection in patients admitted two ETCs forested areas Guinea. pattern signs was recorded, an etiological...
BackgroundLassa fever is a viral haemorrhagic endemic in parts of west Africa. New treatments are needed to decrease mortality, but pretrial reference data on the disease characteristics scarce. We aimed document baseline and outcomes for patients hospitalised with Lassa Nigeria.MethodsWe did prospective cohort study (LASCOPE) at Federal Medical Centre Owo, Nigeria. All admitted confirmed were invited participate asked give informed consent. Patients all ages, including newborn infants,...
The COVID-19 pandemic has demonstrated the need for massively-parallel, cost-effective tests monitoring viral spread. Here we present SARSeq, saliva analysis by RNA sequencing, a method to detect SARS-CoV-2 and other respiratory viruses on tens of thousands samples in parallel. SARSeq relies next generation sequencing multiple amplicons generated multiplexed RT-PCR reaction. Two-dimensional, unique dual indexing, using four indices per sample, enables unambiguous scalable assignment reads...
This cohort study evaluated the protection against symptomatic Omicron BA.5 infection conferred by Pfizer-BioNTech Original/BA.4-5 bivalent vaccine compared to mRNA Original monovalent vaccines (Pfizer- BioNTech or Moderna). Individuals of ≥60 years old, who received a booster dose between 03/10/2022 and 06/11/2022, when both were used in France, included matched according type received. The outcome interest was positive SARS-CoV-2 RT-PCR antigenic test associated self-reported symptoms, ≥...
BACKGROUND. The West African Ebola virus epidemic from 2014–2016 highlighted the lack of knowledge about pathogenicity and factors responsible for outcome. A performant rapid diagnosis is crucial importance, as overcoming difficulty providing high-quality patient management during such an extensive outbreak. Here, we propose to study role immune mediators disease define some molecules importance in
Abstract Lassa virus (LASV) is endemic in West Africa and induces a viral hemorrhagic fever (VHF) with up to 30% lethality among clinical cases. The mechanisms involved control of or, contrast, the ensuing catastrophic illness death are poorly understood. We used cynomolgus monkey model reproduce human disease asymptomatic mild or fatal disease. After initial replication at inoculation site, LASV reached secondary lymphoid organs. did not spread further nonfatal was rapidly controlled by...
In face of evidence rapid waning vaccine effectiveness against Omicron and its sub-lineages, a second booster with mRNA vaccines was recommended for the most vulnerable in France. We used test negative design to estimate relative first protection conferred by previous SARS-CoV-2 infection, symptomatic BA.2 or BA.4/5. included ≥60 years old individuals tested March 21-October 30, 2022. Compared 181-210 days booster, restored 41% [95%CI: 39-42%], 7-30 post-vaccination. This gain lower than one...
Lassa virus (LASV) is responsible for a viral hemorrhagic fever in humans and the death of 3,000 to 5,000 people every year. The immune response LASV poorly understood, but type I interferon (IFN-I) T-cell responses appear be critical host. We studied myeloid dendritic cells (mDC) LASV, as mDCs are involved both IFN-I production activation. compared primary human Mopeia (MOPV), which similar non-pathogenic. showed that produced substantial amounts MOPV. However, only MOPV-infected were able...
Brucellosis is a zoonotic disease caused by Brucella spp. and major concern for livestock. Most human cases are B. melitensis clinical presentation usually mild febrile illness. However, treatment failure frequent more severe complications can occur. In Austria, every brucellosis investigated to determine whether it was imported from endemic areas or the sign of an undetected autochthonous transmission. For this study, 21 strains isolated in Austria between 2005 2019 were collected, 17 15...
In February 2022, samples collected in northwest France showed discordant molecular results. After virological and epidemiological investigations, 17 cases of Deltacron XD recombinant severe acute respiratory syndrome coronavirus 2 were confirmed by sequencing or suspected due to links, showing evidence an extended transmission event circulation this form, with low clinical severity.
Abstract This cohort study aimed to evaluate the protection against symptomatic SARS-CoV-2 infection conferred by Pfizer-BioNTech Original/BA.4-5 bivalent vaccine compared mRNA Original (ancestral) monovalent vaccines. Individuals of ≥60 years old who received a booster dose between 03/10/2022 and 06/11/2022, when both vaccines were used in France, included. with (1) (Pfizer- BioNTech or Moderna) (2) matched. The outcome interest was positive RT-PCR antigenic test associated self-reported...
We present the findings from European Programme for Intervention Epidemiology Training (EPIET) Alumni Network (EAN) Member Survey conducted in October to December 2021. The EAN consists of field epidemiologists and public health microbiologists (European Public Health Microbiology (EUPHEM)) who stay connected after their 2-year fellowship. This active alumni network provides opportunities career development, mentorship, knowledge exchange sharing best practices community members, affiliated...
Abstract Background A rapid increase in incidence of the SARS-CoV-2 Omicron variant occurred France December 2021, while Delta was prevailing since July 2021. We aimed to determine whether risk a severe hospital event following symptomatic infection differs for versus Delta. Methods conducted retrospective cohort study compare events (admission intensive care unit or death) between and cases matched according week virological diagnosis age. The analysis adjusted age, sex, vaccination status,...
We aimed to describe the characteristics of individuals infected by BA.4 or BA.5 in France comparison BA.1, and analyze factors associated with hospitalization among cases. A standardized questionnaire was used collect information on confirmed probable Omicron Hospitalization risk BA.4/BA.5 cases were analyzed using Poisson regression. Variables a p-value below 0.2 univariate analysis priori confounders included multivariable regression model. The median age 301 investigated 47 years 97%...
Diphtheria is a vaccine-preventable disease with high potential for reemergence. One of its causative agents Corynebacterium diphtheriae, some strains producing diphtheria toxin. From 2011 to 2019, 57 clinical C. diphtheriae were isolated in Austria, either from the respiratory tract or skin infections. The aim this study was investigate genetic diversity these isolates using whole-genome sequencing. Isolates characterized by genome-wide comparisons single nucleotide polymorphism analysis...
We investigated genomic determinants of antimicrobial resistance in 1,318 Neisseria gonorrhoeae strains isolated Austria during 2016-2020. Sequence type (ST) 9363 and ST11422 isolates had high rates azithromycin resistance, ST7363 correlated with cephalosporin resistance. These results underline the benefit surveillance for monitoring.
SUMMARY Viral pandemics, such as Covid-19, pose serious threats to human societies. To control the spread of highly contagious viruses SARS-CoV-2, effective test-trace-isolate strategies require population-wide, systematic testing. Currently, RT-qPCR on extracted RNA is only broadly accepted test for SARS-CoV-2 diagnostics, which bears risk supply chain bottlenecks, often exaggerated by dependencies proprietary reagents. Here, we directly compare performance gold standard diagnostic direct...
Lassa virus (LASV) causes a viral haemorrhagic fever in humans and is major public health concern West Africa. An efficient immune response to LASV appears rely on type I interferon (IFN-I) production T-cell activation. We evaluated the of plasmacytoid dendritic cells (pDC) LASV, as they are an important early source IFN-I. compared primary human pDCs Mopeia (MOPV), which very closely related but non-pathogenic. showed that not productively infected by either MOPV or produce However,...
Lassa Fever (LF), is a severe viral disease prevalent in Western Africa. It classified as priority by the World Health Organization (WHO). Ribavirin recommended therapy despite weak evidence of its efficacy. Promising therapeutic agents are becoming available for evaluation human. Before launching trials, we need data on evolution under best possible conditions care. We have initiated prospective study Nigeria to better understand clinical course and prognostic factors LF while implementing...
There is an increasing emphasis on identifying individuals with schizophrenia earlier and in their disease process, the assumption that identification translates into treatment, which improved outcome. Unfortunately, one age cohort, children under 13 years of age, have been excluded from this critical alteration clinical inter-vention strategy, its associated One barriers to inclusion younger lack knowledge about diagnostic issues related attenuated psychotic symptoms sample. This report...
Abstract In face of evidence rapid waning vaccine effectiveness against Omicron and its sub-lineages, a second booster with mRNA vaccines was recommended for the most vulnerable in France. We used test negative design to estimate relative first protection conferred by previous SARS-CoV-2 infection, symptomatic BA.2 or BA.4/5. included ≥60 years old individuals tested March 21-October 30, 2022. Compared 181-210 days booster, restored 39% [95%CI: 38% - 41%], 7-30 post-vaccination This gain...