A5014872134- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Nonmelanoma Skin Cancer Studies
- Polyomavirus and related diseases
- Carcinogens and Genotoxicity Assessment
- Cutaneous lymphoproliferative disorders research
- Cytomegalovirus and herpesvirus research
- Autoimmune Bullous Skin Diseases
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Bacterial Infections and Vaccines
- Nail Diseases and Treatments
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- Toxic Organic Pollutants Impact
- Autoimmune and Inflammatory Disorders
- Immunotoxicology and immune responses
- Hematopoietic Stem Cell Transplantation
- Cervical Cancer and HPV Research
- Skin Protection and Aging
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Ocular Diseases and Behçet’s Syndrome
- Drug-Induced Adverse Reactions
Medical University of Vienna
2014-2024
University of Tübingen
2023
European Centre for Disease Prevention and Control
2022
Austrian Agency for Health and Food Safety
2022
Paracelsus Medical University
2022
University of Salzburg
2022
BOKU University
2022
Universitätszahnklinik Wien
2017-2021
University of Vienna
1995-2011
Universitätsmedizin Greifswald
2008-2011
The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacological activation promising strategy for skin protection cancer prevention. We show here that prolonged in keratinocytes causes sebaceous gland enlargement seborrhea mice due to upregulation growth epigen, which we identified as novel target. This was accompanied by thickening hyperkeratosis hair follicle infundibula. These abnormalities caused dilatation infundibula, loss, cyst development upon...
Primary cutaneous posttransplant lymphoproliferative disorders (PTLD) are rare. This retrospective, multicenter study of 35 cases aimed to better describe this entity. Cases were (re)-classified according the WHO-EORTC or WHO 2008 classifications lymphomas. Median interval between first transplantation and diagnosis was 85 months. Fifty-seven percent patients had a kidney transplant. Twenty-four (68.6%) classified as primary T cell lymphoma (CTCL) 11 (31.4%) B PTLD. Mycosis fungoides (MF)...
Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome (OMIM 604416) is a rare autosomal dominant inherited autoinflammatory characterized by pyogenic arthritis less frequently accompanied gangrenosum acne. It associated with missense mutations in the proline-serine-threonine phosphatase-interacting protein 1 gene (PSTPIP1) located on chromosome 15. The patient was diagnosed as having features of PAPA-like which cutaneous manifestations, such fulminans,...
Use of immune checkpoint inhibitors (ICIs) in solid organ transplant recipients (SOTRs) with advanced skin cancers presents a significant clinical management dilemma. SOTRs and other immunosuppressed patients have been routinely excluded from ICI trials good reason: checkpoints play an important role self- allograft-tolerance risk acute allograft rejection reported retrospective studies affects 10% to 65% cases. These reports also confirm that cutaneous squamous cell carcinoma melanoma...
A variety of health effects have been attributed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), but little information is available on the course a verified high-level TCDD intoxication. In this paper we describe two cases heavy intoxication with and present 2-year follow-up including clinical, biochemical, hematologic, endocrine, immunologic parameters monitored in women, 30 27 years age, who suffered from chloracne due unknown origin. Patient 1, had highest level ever recorded an...
There is a paucity of evidence to guide physicians regarding prevention strategies for cutaneous squamous cell carcinoma (CSCC) in solid organ transplant recipients (SOTRs).To examine the development and results Delphi process initiated identify consensus-based medical management recommendations CSCC SOTRs.Dermatologists with more than 5 years' experience treating SOTRs were invited participate. A novel actinic damage skin cancer index (AD-SCI), consisting 6 ordinal stages corresponding an...
This retrospective study on syphilis screening at the sexually transmitted infection (STI) unit of a University Department emphasizes necessity treponemal-specific test as appropriate test. The Venereal Disease Research Laboratory (VDRL) for may, under certain circumstances, yield positive results in patients not infected with Treponema pallidum, phenomenon referred to biological false-positive (BFP) VDRL aim this was determine frequency BFP tests large sample sera. In study, we analysed...
In 1995, a 40-year-old heterosexual man developed perianal tumor that rapidly increased in size. Following clinical and histologic diagnosis of large condyloma acuminatum (CA), the was partially resected primary care hospital. Subsequently, recurrent fistulae abscesses required several surgical interventions, patient underwent transverse colostomy to allow subsequent complete resection condyloma. At patient’s first visit our clinic 1996, physical examination demonstrated smooth, exophytic,...
Since 2003, an ongoing outbreak of lymphogranuloma venereum (LGV), caused by Chlamydia trachomatis biovar L2b, has been reported among men who have sex with men.Twenty-four samples positive for C. were analyzed specific biovars and genovariants genotyping the variable segment (VS) 4, VS2 VS1 regions outer membrane protein (omp) A. In addition we assessed patients' sociodemographic background clinical signs symptoms.Twenty-four presented either anorectal or inguinal symptoms tested DNA. Of...
Abstract Background Solid organ transplant recipients have a high risk of developing nonmelanoma skin cancers (NMSC). We describe the characteristics and incidence tumors in an Austrian population heart (HTR). Methods Three hundred twenty‐two HTR out 970 who had received their between December 1984 July 2003 were analyzed for NMSC. Factors associated with tumor development including different immunosuppressive (IS) modalities evaluated. Besides triple combination therapy, all allograft...
Objective The correct in vivo quantification of aryl hydrocarbon receptor‐mediated induction cytochrome P450 1A2 (CYP1A2) humans is a long‐standing question. We compared the performance several modifications caffeine test for measurement CYP1A2 activity subjects with exceptionally high, low, or absent enzyme induction. Methods was measured 2 women highly exposed to 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD), 1 man moderately exposed, and 50 control (30 nonsmokers 20 heavy smokers). After...
Patients with latent syphilis or of unknown duration should be evaluated for tertiary disease and neurosyphilis. The aim this retrospective study was to determine relevant serological parameters the identification those individuals who are most likely have neurosyphilis therefore require lumbar puncture. After excluding repeated estimates patients whose blood serology had either been negative not determined within 3 months puncture, 265 out 710 cerebrospinal fluids from 1988 2004 were...
Developing effective therapies against chronic wound healing deficiencies is a global priority. Thus we evaluated the safety of two different doses topically administered autologous APOSEC, secretome apoptotic peripheral blood mononuclear cells (PBMCs), in healthy male volunteers with artificial dermal wounds. Ten men were enrolled single-center, randomized, double-blinded, placebo-controlled phase 1 trial. Two wounds at upper arm generated using 4-mm punch biopsy. Each participant was...
Abstract Background The proportion of Merkel cell carcinomas (MCCs) in solid‐organ transplant recipients (SOTR) harbouring polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes. Objective To describe clinicopathological features MCC SOTR, investigate the tumoral MCPyV‐status and identify associated with tumour Methods Retrospective, international, cohort‐study. was investigated by immunohistochemistry polymerase chain reaction. Results A total 30 SOTR 44 consecutive...