A5059780882- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Retinal Diseases and Treatments
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Glaucoma and retinal disorders
- Cardiovascular Issues in Pregnancy
- Trace Elements in Health
- Orthopaedic implants and arthroplasty
- Blood properties and coagulation
- Wound Healing and Treatments
- Electrolyte and hormonal disorders
- Retinal Imaging and Analysis
- Analytical Methods in Pharmaceuticals
- Pharmaceutical Economics and Policy
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antioxidant Activity and Oxidative Stress
- Bone health and treatments
- Pressure Ulcer Prevention and Management
Medical University of Vienna
2009-2020
Boehringer Ingelheim (Germany)
2013
Sinai Hospital
2013
Wilhelminen Hospital
2013
Radboud University Nijmegen
2013
Kaiser-Franz-Josef-Spital
2012
Vienna General Hospital
2008-2010
Universitätszahnklinik Wien
2006-2008
Landeskrankenhaus Feldkirch
2003-2006
Vorarlberg Institute for Vascular Investigation and Treatment
2003-2006
Experimental studies have shown that liposomal curcumin can exert a reduction in tumor growth pancreatic and colorectal cancer. In this phase I clinical trial we investigated the pharmacokinetics, safety, tolerability of intravenously administered healthy subjects.50 male female participants were included randomized, placebo-controlled double-blind dose escalation study. Subjects received single (10 - 400 mg/m2; n = 2 6 per group) or placebo over hours intravenously.Dose-dependent increases...
Heme oxygenase-1 (HO-1) has been proposed to exert pharmacological benefits by its antioxidative and anti-inflammatory effects. HO-1 expression may be affected the GT length polymorphism in promoter region of gene. We investigated inducibility orally administered curcumin healthy male subjects correlation with polymorphism.In an open label uncontrolled phase-1 pilot study, ten received 12 g oral curcumin. To investigate effects on HO-1, five homozygous short long genotypes were studied....
The aim of this study was to investigate the effect alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus.A total 30 subjects were included randomized, controlled, double-blinded, parallel group study. FBF responses intra-arterial acetylcholine (ACh) glycerol trinitrate (GTN) measured before after 21 days intravenous 600 mg or placebo.FBF comparable at baseline. After...
Summary C-reactive protein (CRP) protects against bacterial pathogens and is a predictor of cardiovascular events. CRP produced by vascular organ-specific cells but the generation from peripheral blood mononuclear (PBMC) poorly established. In randomized, double-blind, placebo-controlled, two-way cross-over trial six healthy volunteers received bolus infusion 20 IU/kg Escherichia coli endotoxin [lipopolysaccharide (LPS)] or placebo. Intracellular secretion was measured at baseline 6 h after...
Several test systems exist for assessment of platelet function in patients under clopidogrel or aspirin therapy. The objective was to cross-validate the Multiple Electrode Aggregometry (MEA) with three other methods used determining reactivity treatment and aspirin. Platelet assessed by MEA, Vasodilator Stimulated Phosphoprotein (VASP) phosphorylation assay, Function Analyzer-100 (PFA-100) Cone Analyzer. Measurements were performed blood from nine healthy volunteers at baseline, 2, 4, 6 72...
Serial measurements of neurohormones have been shown to improve prognostication in the setting acute heart failure (HF) or chronic HF without therapeutic intervention. We investigated prognostic role serial emerging and BNP a cohort patients undergoing increases HF-specific therapy.In this prospective study we included 181 with systolic after an episode hospitalization for worsening HF. Subsequently, therapy was gradually increased outpatient until optimized. measured copeptin, midregional...
Experimental data imply that in decompensated heart failure (HF), the anti-angiogenic factor endostatin is increased. This study aimed to investigate whether angiogenesis inhibitor related risk of all-cause mortality a prospective cohort chronic HF patients.In this observational study, serum concentrations were determined patients with HF. Mortality recorded during median follow-up 31 months.One fifty one included. The overall rate was 20%. Baseline > 245 ng/mL associated higher [HR 8·7 (95%...
Developing effective therapies against chronic wound healing deficiencies is a global priority. Thus we evaluated the safety of two different doses topically administered autologous APOSEC, secretome apoptotic peripheral blood mononuclear cells (PBMCs), in healthy male volunteers with artificial dermal wounds. Ten men were enrolled single-center, randomized, double-blinded, placebo-controlled phase 1 trial. Two wounds at upper arm generated using 4-mm punch biopsy. Each participant was...
High levels of the plasma peptides mid-regional pro-adrenomedullin (MR-proADM) and pro-atrial natriuretic peptide (MR-proANP) are associated with clinical outcomes in general population. Data patients chronic kidney disease sparse. We therefore investigated association MR-proANP MR-proADM all-cause cardiovascular (CV) mortality, CV events peripheral arterial 201 incident dialysis INVOR-Study prospectively followed for a period up to more than 7 years. The overall mortality rate was 43%,...
Aims We aimed to evaluate the association of nutritional status by using risk index (NRI) with metabolic and inflammatory biomarkers, appetite-regulatory hormones in a cohort stable patients heart failure (HF), analyse its prognostic value. Methods results In this prospective observational study, we included 137 chronic HF (median age, 60 years; median body mass index, 27 kg/m2) optimised medical treatment. Baseline NRI < 113 (n = 45) was associated significant increase levels ghrelin (p...
In an ageing society, chronic ulcers pose increasingly relevant healthcare issue associated with significant morbidity and increasing financial burden. Hence, there is unmet medical need for novel, cost-effective therapies that improve healing of cutaneous wounds. This prospective, randomised, open-label, phase I trial investigated the safety tolerability topically administered purified clinoptilolite-tuff (PCT), mainly consisting naturally occurring zeolite-mineral clinoptilolite, in...
Clarithromycin, known as a potent inhibitor of the cytochrome P450 isoenzyme CYP3A, may increase plasma concentration statins metabolized by this pathway; therefore, risk interaction with in reference to pharmacokinetic studies. This study aimed characterize whether concomitant use statin clarithromycin is associated serious outcomes among adult persons. Health claims data persons Regional Sickness Fund Burgenland, Austria, who filled prescription for between July 1, 2009 and June 30, 2012...
Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect purified tuff (G-PUR) on enteral uptake in adults using stable isotope 204Pb as tracer. In this randomized, placebo-controlled, double-blind, parallel-group study, 42 healthy participants were randomized receive oral G-PUR 2.0 g, 2 * or placebo, together with 2.5 µg water. The enrichment...