A5018390548- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Reproductive tract infections research
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Advanced Biosensing Techniques and Applications
- Syphilis Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Medicine and Dermatology Studies History
- Psoriasis: Treatment and Pathogenesis
- Sarcoidosis and Beryllium Toxicity Research
- Genital Health and Disease
- IL-33, ST2, and ILC Pathways
- Mast cells and histamine
- Autoimmune and Inflammatory Disorders
- Drug-Induced Adverse Reactions
- Cytokine Signaling Pathways and Interactions
- Vector-borne infectious diseases
- Extracellular vesicles in disease
- Cervical Cancer and HPV Research
Medical University of Vienna
2016-2025
CeMM Research Center for Molecular Medicine
2019-2025
Austrian Academy of Sciences
2019-2025
Universitätszahnklinik Wien
2020-2024
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases
2019-2023
Austrian Society of Dermatology and Venereology
2008-2023
University Dermatology
2020-2023
University of Vienna
2003-2022
Ludwig Boltzmann Institute for Digital Health and Prevention
2022
Wienerberger (Czechia)
2019
Imiquimod (IMQ), a synthetic agonist to Toll-like receptor (TLR) 7, is being successfully used for the treatment of certain skin neoplasms, but exact mechanisms by which this compound induces tumor regression are not yet understood. While treating basal cell carcinoma (BCC) patients with topical IMQ, we detected, immunohistochemistry, sizable numbers both myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs) within inflammatory infiltrate. Surprisingly, peritumoral mDCs stained positive...
Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ-producing CD4 T cells. By contrast, we report mucosal exposure to ultraviolet light (UV)-inactivated Ct (UV-Ct) generated regulatory cells exacerbated subsequent infection. We show immunization with UV-Ct complexed charge-switching synthetic adjuvant particles (cSAPs) elicited long-lived protection in conventional and humanized mice. UV-Ct-cSAP targeted immunogenic uterine CD11b(+)CD103(-)...
Granulomas are lumps of immune cells that can form in various organs. Most granulomas appear unstructured, yet they have some resemblance to lymphoid To better understand granuloma formation, we performed single-cell sequencing and spatial transcriptomics on from patients with sarcoidosis bioinformatically reconstructed the underlying gene regulatory networks. We discovered an stimulatory environment repurposes transcriptional programs associated organ development. Granuloma formation...
PKC isoforms tau, alpha, and beta play fundamental roles in the activation of T cells other immune cell functions. Here we show that inhibitor AEB071 both abolishes production several cytokines by activated human cells, keratinocytes, macrophages vitro inhibits an acute allergic contact dermatitis response rats. To translate these findings into humans, single multiple ascending oral doses were administered to healthy volunteers patients with psoriasis, respectively. was well tolerated no...
Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in United States. infections that ascend to upper genital tract can persist, trigger inflammation, and result serious sequelae such as infertility. However, mouse models which vaginal vault inoculated with C. do not recapitulate course of human disease. These intravaginal efficiently tract, cause persistent infection, induce significant CD4⁺ T cell infiltration. In this article, we describe a...
GVHD includes an autoinflammatory host-versus-graft component from recipient-derived skin-resident memory T cells.
Experimental data suggest that bacterial translocation (BT) promotes systemic inflammation, portal hypertension, and circulatory dysfunction in advanced chronic liver disease (ACLD).Patients with ACLD undergoing hepatic venous pressure gradient (HVPG) measurement absence of acute decompensation or infections were included (n = 249). Serum biomarkers BT (lipopolysaccharide [LPS], lipoteichoic acid [LTA], DNA [bactDNA]), inflammation markers assessed. T-cell subsets intestinal biopsies 7 ACLD,...
Abstract Dendritic cells (DCs) not only exhibit the unique capacity to evoke primary immune responses, but may also acquire TLR-triggered cytotoxic activity. We and others have previously shown that TLR7/8- TLR9-stimulated plasmacytoid DCs (pDCs) isolated from human peripheral blood express effector molecule TRAIL. The exact mechanisms through which pDCs elicit their activity are still clear. now show in absence of costimulators, TRAIL induction on occurs with agonists intracellular TLRs is...
Emigration of tissue-resident memory T cells (TRMs) was recently introduced in mouse models and may drive systemic inflammation. Skin TRMs patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) can coexist beside donor cells, offering a unique human model system to study migration. By genotyping, mathematical modeling, single-cell transcriptomics, functional analysis patient blood skin we detected small consistent population circulating skin-derived with TRM phenotype...
Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to would aid in new therapeutic development.
Postoperative pain affects most patients after major surgery and can transition to chronic pain. The considerable side effects limited efficacy of current treatments underline the need for new therapeutic options. We observed increased amounts metabolites BH4 serotonin skin injury. Mast cells were primary postoperative sources Gch1 , rate-limiting enzyme in synthesis, itself an obligate cofactor production by tryptophan hydroxylase (Tph1). Mice deficient mast or cell–specific Tph1 showed...
Abstract Although glucocorticosteroids (GCSs) have been used for many decades in transplantation and (auto)inflammatory diseases, the exact mechanisms responsible their immunosuppressive properties are not fully understood. The purpose of this study was to characterize effects oral GCSs on cutaneous immune response. We analyzed, by immunofluorescence staining quantitative RT-PCR, residual skin biopsy material from a clinical which we had GCS as positive control determining candidate...
Cervical intraepithelial neoplasia (CIN) is a common disease among women of reproductive age. High-grade CIN lesions (CIN 2–3) are precancerous and can progress to cervical cancer. The most important risk factor for the development progression cancer persistent high-risk human papillomavirus (HPV) infection. preferred treatment in countries surgical excision using conization. There high need medical alternative therapy 2–3 largely because preterm birth other long-term sequelae conization...
Adaptive features of natural killer (NK) cells have been reported in various species with different underlying mechanisms. It is unclear, however, which NK cell populations are capable mounting antigen-specific recall responses and how such functions regulated at the molecular level. Here, we identify characterize a discrete population CD49a+CD16- human liver that displays increased epigenetic potential to elicit memory has functional properties exert immunity skin as an effector site....
Summary Background and Objectives Serovar L1–L3 of Chlamydia trachomatis (CT) causes lymphogranuloma venereum (LGV). A surge in LGV‐cases has been observed among HIV‐positive men who have sex with (MSM). Discrimination between LGV non‐LGV is pivotal since it major treatment implications. Here, we aimed to determine the prevalence characteristics CT‐infections. Patients Methods All CT‐positive results from 04/2014–12/2021 at four largest Austrian HIV STI clinics were evaluated. Disease...
Targeting of the proinflammatory cytokine interleukin 17A (IL-17A) or tumor necrosis factor alpha (TNFα) with monoclonal antibodies (mAbs) ixekizumab adalimumab, respectively, is a successful therapy for chronic plaque psoriasis. The effects these treatments on immune cell populations in skin are largely unknown. In this study, we compared composition cutaneous, lesional and non-lesional cells blood ixekizumab- adalimumab-treated patients Our data reveal that both efficiently downregulate T...