A5039907008- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Dermatology and Skin Diseases
- Cell Adhesion Molecules Research
- Sepsis Diagnosis and Treatment
- Microplastics and Plastic Pollution
- Cytokine Signaling Pathways and Interactions
- Skin and Cellular Biology Research
- Eosinophilic Disorders and Syndromes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Medicine and Dermatology Studies History
- Connexins and lens biology
- COVID-19 Clinical Research Studies
- Toxic Organic Pollutants Impact
- Corneal Surgery and Treatments
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Vascular Anomalies and Treatments
- Kruppel-like factors research
- Effects and risks of endocrine disrupting chemicals
Ludwig Boltzmann Institute for Lung Vascular Research
2023
Medical University of Graz
2016-2021
University Dermatology
2021
FH Campus Wien
2021
Centre National de la Recherche Scientifique
2019
Institut de Biologie Moléculaire et Cellulaire
2019
University Medical Center of the Johannes Gutenberg University Mainz
2019
Johannes Gutenberg University Mainz
2019
Medical University of Vienna
2019
Immunologie, Immunopathologie et Chimie Thérapeutique
2019
Abstract Dendritic cells (DCs) have been implicated in the pathogenesis of psoriasis but roles for specific DC subsets are not well defined. Here we show that DCs required psoriasis-like changes mouse skin induced by local injection IL-23. However, Flt3L-dependent and resident Langerhans dispensable inflammation. In epidermis dermis, critical TNF-producing IL-1β-producing monocyte-derived DCs, including a population inflammatory cells. Depleting Ly6C hi blood monocytes reduces accumulation...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Immune cell recruitment, endothelial barrier disruption, and platelet activation are hallmarks of lung injuries caused by COVID-19 or other insults which can result in acute respiratory distress syndrome (ARDS). Basement membrane (BM) disruption is commonly observed ARDS, however, the role newly generated bioactive BM fragments mostly unknown. Here, we investigate endostatin, a fragment protein collagen XVIIIα1, on ARDS associated cellular functions such as neutrophil integrity, aggregation...
Langerhans cell (LC) networks play key roles in immunity and tolerance at body surfaces. LCs are established prenatally can be replenished from blood monocytes. Unlike skin-resident dermal DCs (dDCs)/interstitial-type inflammatory dendritic epidermal cells appearing dermatitis/eczema lesions, lack monocyte-affiliated markers. Inversely, express various epithelial genes critical for their long-term peripheral tissue residency.Dendritic (DCs) functionally involved diseases; however, the...
Bone morphogenetic proteins (BMPs) are members of the TGF-β family that signal via BMP receptor (BMPR) signaling cascade, distinct from canonical signaling. downstream is strongly induced within epidermal keratinocytes in cutaneous psoriatic lesions, and BMP7 instructs monocytic cells to acquire characteristics psoriasis-associated Langerhans dendritic (DCs). Regulatory T (Treg)-cell numbers increase during skin inflammation were recently shown limit inflammation. However, factors mediating...
In recent years, accumulating evidence has shown that pulmonary arterial hypertension (PAH) a strong underlying inflammatory component. Vascular remodeling, common pathology observed in all forms of (PH), is accompanied by pronounced accumulation leukocytes around and within the vessels. Proteolytic products immune cells, particularly neutrophil mast cell serine proteases, have been to play central pathogenic role vascular remodeling PAH development. Serine proteases are involved many...
Reticulon 1A (RTN1A) is an endoplasmic reticulum-associated protein and besides its expression in neuronal tissues, a marker for cells of the dendritic lineage, including epidermal Langerhans (LCs) dermal (DCs) humans.Expression RTN1A before appearance LC markers during skin development suggests that it may play role differentiation/migration process.To obtain prenatal human challenging, therefore studies were continued wild-type C57BL/6 mice to unravel cutaneous physiology.Intriguingly,...