A5034134955- Neuroscience and Neuropharmacology Research
- Phosphodiesterase function and regulation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Chemotherapy-induced cardiotoxicity and mitigation
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Asthma and respiratory diseases
- Cholinesterase and Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Plant biochemistry and biosynthesis
- Skin Protection and Aging
- Cancer Treatment and Pharmacology
- Pharmacological Receptor Mechanisms and Effects
- Lichen and fungal ecology
- Synthesis and Biological Evaluation
- Crystallography and molecular interactions
- Phytochemistry and Biological Activities
- Pharmaceutical and Antibiotic Environmental Impacts
- Metal complexes synthesis and properties
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Microbial Natural Products and Biosynthesis
- Pain Mechanisms and Treatments
- Mast cells and histamine
Jagiellonian University
2016-2025
Humboldt-Universität zu Berlin
2023
Charité - Universitätsmedizin Berlin
2023
Freie Universität Berlin
2023
Lukasiewicz Research Network - Krakow Institute of Technology
2021
Cracow University of Technology
2018
Fluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of “click” chemistry strategy. probes for this approach can be constructed by linking an azide or alkyne group to a fluorophore, such as recently developed Safirinium derivatives. These compounds are water-soluble, highly fluorescent heterocycles based on 1,2,4-triazolium, with significant potential various applications, although they have not yet been converted...
Phosphodiesterase (PDE) inhibitors are currently a widespread and extensively studied group of anti-inflammatory anti-fibrotic compounds which may find use in the treatment numerous lung diseases, including asthma chronic obstructive pulmonary disease. Several PDE clinical development, some them, e.g., roflumilast, already recommended for use. Due to reports indicating that elevated intracellular cAMP levels contribute alleviation inflammation airway fibrosis, new effective constantly being...
An anticancer azo bond-containing half-sandwich Ir( iii ) complex oxidizes ascorbate to dehydroascorbate, and recovers in the presence of reduced glutathione.
In light of the multifactorial origin neurodegenerative disorders and some body evidence indicating that pharmacological blockade serotonin 5-HT6 dopamine D3 receptors might be beneficial for cognitive decline, we envisioned (S)-1-[(3-chlorophenyl)sulfonyl]-4-(pyrrolidine-3-yl-amino)-1H-pyrrolo[3,2-c]quinoline (CPPQ), a neutral antagonist 5-HT6R, as chemical template designing dual antagonists 5-HT6/D3 receptors. As shown by in vitro experiments, supported quantum calculations molecular...
G-protein coupled receptors (GPCRs) exist in an equilibrium of multiple conformational states, including different active which depend on the nature bound ligand. In consequence, states can initiate specific signal transduction pathways. The study identified compound 7e, acts as a potent 5-hydroxytryptamine type 6 receptor (5-HT6R) neutral antagonist at Gs and does not impact neurite growth (process controlled by Cdk5). MD simulations highlighted changes for 7e inverse agonist PZ-1444....
Doxorubicin (DOX) is a widely used anticancer drug. However, its clinical use severely limited due to drug-induced cumulative cardiotoxicity, which leads progressive cardiomyocyte dysfunction and heart failure. Enormous efforts have been made identify potential strategies alleviate DOX-induced cardiotoxicity; however, date, no universal highly effective therapy has introduced. Here we reported that cinnamic acid (CA) derivatives exert multitarget protective effect against cardiotoxicity. The...
Abstract Poly(allylamine hydrochloride) (PAH) has found many applications both in biotechnology and biomedical fields. However, its high toxicity toward various mammalian cells significantly limits effective usage. This study focuses on improving the biological properties of PAH by modification to strong polyelectrolytes. The polycations were prepared direct quaternization amino groups or attachment glycidyltrimethylammonium chloride these groups. properties, such as cytotoxicity human skin...