A5077436871- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Lichen and fungal ecology
- Phytochemical Studies and Bioactivities
- Plant biochemistry and biosynthesis
- Phytochemistry and Bioactive Compounds
- Bioactive Compounds and Antitumor Agents
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Phytochemical compounds biological activities
- Bryophyte Studies and Records
- Medicinal plant effects and applications
- Microbial Natural Products and Biosynthesis
- Garlic and Onion Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Seed and Plant Biochemistry
- Plant Pathogens and Fungal Diseases
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Phytochemistry Medicinal Plant Applications
- Phytoestrogen effects and research
- Medicinal Plants and Bioactive Compounds
- Tea Polyphenols and Effects
- Botany and Plant Ecology Studies
Jagiellonian University
2016-2025
Farmak (Czechia)
2019
Introduction: Adaptogens are a group of plants that exhibit complex, nonspecific effects on the human body, increasing its ability to adapt, develop resilience, and survive in stress conditions. They found many traditional medicinal systems play key role restoring body’s strength stamina. Research recent years has attempted elucidate mechanisms behind their pharmacological effects, but it appears these difficult define precisely involve multiple molecular pathways. Neuroinflammation: In...
Abstract Steroidal saponins are a group of glycosides widely distributed among monocotyledonous families. They exert wide spectrum biological effects including cytotoxic and antitumor properties which the most studied. This review is an update our previous paper— Saponins as agents (Podolak et al. in Phytochem Rev 9:425–474, 2010) covers studies that were since published (2010–2018). In this paper we refer to steroidal presenting results cytotoxicity studies, mechanisms action...
Citrus hystrix DC. peel essential oil (ChEO) has been reported to have many biological activities and is promoted for topical application. However, its effect on skin functioning not yet studied. This study aimed evaluate safety normal cells as well potential activity against human melanoma. In addition, pro-inflammatory anti-inflammatory was assessed, inhibitory effects important enzymes: tyrosinase hyaluronidase. To better understand the complexity of action ChEO role individual...
Abstract Saponins make up an important group of natural glycosidic compounds which are distinguished by triterpene or steroidal aglycone. Although widely distributed in terrestrial flora, especially higher plants, they can also be found some marine organisms. Cytotoxic activity is one the most frequently reported from a wide array pharmacological activities known for these metabolites. The current review update our previous paper— as cytotoxic agents (Podolak et al. Phytochem Rev 9:425–474,...
Vasorelaxant and antiplatelet agents play an important role in preventing combating endothelial dysfunction, atherosclerosis a plethora of associated cardiovascular diseases (CVDs). CVDs are the leading cause death worldwide nowadays occur not only developed but also developing societies. They include, among others, coronary heart disease, cerebrovascular disease peripheral artery disease. Due to their high prevalence, it is seek efficient preventive measures, such as lifestyle changes...
Calenduloside E (CE) and chikusetsusaponin IVa (ChIVa) are triterpene saponins with multidirectional bioactivity. In this study, the contents of CE ChIVa were determined in roots, stems, leaves, fruits ten wild-growing species Amaranthaceae. To achieve optimal extraction conditions for both saponins, maceration, shaking-assisted ultrasound-assisted heat reflux compared. A sensitive, specific, rapid UPLC-MS/MS method was developed validated simultaneous quantification ChIVa. The results...
This study investigates the phytochemical composition and biological activities of hemp (
The in vitro anti-denaturation and anti-hyaluronidase activities of Impatiens parviflora extracts isolated galactolipids (MGDG-1, DGDG-1) were investigated. This is the first report on these compounds I. parviflora. All showed activity, but only methanolic extract from fresh leaves exhibited significant activity against heat-induced denaturation BSA a dose-dependent manner. At 500 μg/mL, reference drug 79.05% 99.81% inhibition protein denaturation, respectively. These results indicate that...
Two triterpene saponins (IPS-1, IPS-2) for the first time were isolated from roots of Impatiens parviflora DC. (Balsaminaceae). Their anti-inflammatory activity was evaluated by means two in vitro models: anti-hyaluronidase and anti-denaturation assays. Both shown to be potent hyaluronidase inhibitors that affect enzyme a dose-dependent manner. The effect IPS-2 (IC50 = 286.7 µg/mL) higher than reference drug: escin 303.93 µg/mL). protected bovine serum albumin heat-induced denaturation IPS-1...