A5057884134- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Catalytic Cross-Coupling Reactions
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Silicone and Siloxane Chemistry
- Chemical Synthesis and Reactions
- Polyoxometalates: Synthesis and Applications
- Organometallic Complex Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Quinazolinone synthesis and applications
- Metal-Organic Frameworks: Synthesis and Applications
- Metal complexes synthesis and properties
- Neuroscience and Neuropharmacology Research
- Magnetism in coordination complexes
- Catalytic Alkyne Reactions
- Chemistry and Chemical Engineering
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Receptor Mechanisms and Signaling
- Cyclopropane Reaction Mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical synthesis and alkaloids
Institut des Biomolécules Max Mousseron
2016-2025
Institut Universitaire de France
2022-2024
Université de Montpellier
2015-2024
Centre National de la Recherche Scientifique
2015-2024
École Nationale Supérieure de Chimie de Montpellier
2015-2024
Institut Parisien de Chimie Moléculaire
2009-2020
Sorbonne Université
2009-2020
Université de Haute-Alsace
2020
Université de Rouen Normandie
2020
Bipar
2016-2019
Phosphine-free palladium-catalyzed Mizoroki-Heck reaction was performed using ball-milling in polyethylene glycol under mild conditions. Good to excellent yields of coupling products were obtained. This activation technique also allowed the concomitant formation round shaped Pd-PEG nanoparticles that characterized by TEM analysis.
Abstract Synthetic mechanochemistry, the use of mechanical force produced by milling, grinding or extruding, as an activation technique, provides access to chemical entities all kinds. This Review is focused on examples reported so far known Active Pharmaceutical Ingredients (APIs), and effectively evaluated bioactive molecules, prepared mechanosynthesis. Three families molecules are discussed: heterocyclic compounds, metal complexes peptides. Advantages mechanochemistry approach highlighted...
The synthesis, characterisation and catalytic behaviour of ruthenium indenylidene complexes bearing an N-heterocyclic carbene triisopropylphosphite are described.
Modulators of the serotonin 5-HT6 receptor (5-HT6R) offer a promising strategy for treatment cognitive deficits that are associated with dementia and Alzheimer's disease. Herein, we report design, synthesis, characterization novel class 5-HT6R antagonists is based on 1H-pyrrolo[3,2-c]quinoline core. The most active compounds exhibited comparable binding affinity to reference compound, SB-742457, markedly improved selectivity. Lead optimization led identification...
Ball-milling of heterogeneous metallic copper, O<sub>2</sub> and imidazolium salts enables the highly efficient production Cu–NHC complexes.
Abstract The transmetalation of bimetallic copper–sodium silsesquioxane cages, namely, [(PhSiO 1.5 ) 10 (CuO) 2 (NaO 0.5 ] (“Cooling Tower”; 1 ), 12 4 (“Globule”; and 6 (PhSiO (“Sandwich”; 3 resulted in the generation three types hexanuclear cylinder‐like copper silsesqui‐ oxanes, (C H 9 OH) 5 ( 8 O (PhCN) (MeOH) (NaCl)(C (H O) ). products show a prominent “solvating system–structure” dependency, as determined by X‐ray diffraction. Topological analysis cages – was also performed. In...
A silver-catalyzed cycloisomerization reaction of a series o-alkynylbenzohydroxamic acids is reported. Several 5-exo-dig and 6-endo-dig modes cyclization were observed with the nitrogen or oxygen atoms amide group acting as nucleophiles. The selectivity was strongly dependent on silver salt used presence triphenylphosphine an additive. Indeed, while use Ag2O at room temperature allowed isolation isobenzofuran-1-one oximes (7 compounds, 48–92% yield), [Ag(Im)]n concomitant addition 2 equiv...
Allylic sulfoxides, via [2,3]-sigmatropic rearrangement and oxidative addition of the resulting allylic sulfenate esters to Pd(0), are found be excellent precursors anions. This hitherto unknown reactivity is applied in a new Pd(0)-catalyzed domino sequence involving anion generation followed by arylation afford aryl sulfoxides.
In this report, recent advancements in metal-catalysed homogeneous transformations involving N-heterocyclic carbene (NHC) are described. spite of the efficiency NHCs organocatalysis1 and their advantageous properties coordination chemistry,2 because ever growing interest NHC chemistry space limitations, focus report is transition-metal mediated catalysis.
Ready, steady, copper! The efficient copper-catalyzed formation of amides, from benzylic alcohols and hydrochloride salts primary- secondary amines, uses cheap readily available copper oxide, as well tert-butylhydroperoxide (TBHP) an oxidant. Detailed facts importance to specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made submitted by the authors. Please note: publisher is responsible for content functionality any...
The synthesis of the four olefin metathesis precatalysts Caz-1a–d, featuring NHC ligand N,N′-bis(2,4,6-trimethylphenyl)imidazolin-2-ylidene (SIMes) and different phosphites (P(OiPr)3, P(OPh)3, P(OEt)3, P(OMe)3), is reported. complexes are readily synthesized from commercially available [RuCl2(3-phenylinden-1-ylidene)(pyridine)(SIMes)] (Ind-III) in yields up to 88%. These adopt an unusual cis configuration between phosphite ligands. NMR experiments computational studies confirm that...
The exotic “Asian Lantern” heterometallic cage silsesquioxane [(PhSiO<sub>1.5</sub>)<sub>20</sub>(FeO<sub>1.5</sub>)<sub>6</sub>(NaO<sub>0.5</sub>)<sub>8</sub>(<italic>n</italic>-BuOH)<sub>9.6</sub>(C<sub>7</sub>H<sub>8</sub>)] (<bold>I</bold>) was obtained and characterized by X-ray diffraction, EXAFS, topological analyses DFT calculation.
A solvent-free thermo-mechanochemical synthesis of amides from carboxylic acids and amines, performed by reactive extrusion, in the absence coupling agents, additives or catalyst is reported. We developed a Bayesian optimization approach able to handle holistically various parameters (temperature, reaction time, excess starting material) as well setting target for sustainability. The methodology proved be straightforward, high yielding, sustainable easily optimized each set materials with...
The steric and electronic influence of backbone substitution in IMes-based (IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene) N -heterocyclic carbenes (NHC) was probed by synthesizing the [RhCl(CO) 2 (NHC)] series complexes to quantify experimentally Tolman parameter (electronic) percent buried volume (% V bur , steric) parameters. corresponding ruthenium–indenylidene were also synthesized tested benchmark metathesis transformations establish possible correlations between reactivity NHC
The compounds 4,5-dimethyl-N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene silver chloride [AgCl(IPrMe)] 3 and gold(I) [AuCl(IPrMe)] 4 have been synthesized. attempted synthesis of the corresponding gold(III) by oxidative addition chlorine gas on allowed for formation expected complex, concomitantly with 6, resulting from a chlorination methyl group situated in backbone NHC (N-heterocyclic carbene). Additionally, buried volume %Vbur IPrMe ligand complexes was calculated compared to more...
Abstract The synthesis and characterization of two new ruthenium indenylidene complexes [RuCl 2 (SIPr)(Py)(Ind)] 6 (SIPr)(3‐BrPy)(Ind)] 7 featuring the sterically demanding N‐heterocyclic carbene 1,3‐bis(2,6‐di isopropylphenyl)‐4,5‐dihydroimidazol‐2‐ylidene (SIPr) are reported. Remarkable activity was observed with these in ring closing, enyne, cross metathesis olefins at low catalyst loadings. performance SIPr‐bearing as well (SIPr)(PCy 3 )(Ind)] 5 opening polymerization is also disclosed....
The use of phosphites in second generation, ruthenium-based olefin metathesis pre-catalysts leads to an improvement catalyst stability and activity at low loadings.
The absence of solvent, associated with intensive mechanical agitation, allowed the first mechanosynthesis high-value silver(I)-carbene complexes and corresponding N,N-dialkylimidazolium precursors. This procedure gave outstanding results in terms yield reaction time, when compared to solution-based conditions previously described literature, was generalized unprecedented compounds. Silver(I)-carbene could either be obtained from salts or directly imidazole alkyl halides a one-pot two-step...
A solvent-free synthesis of NHC–silver, gold, copper and palladium complexes in a ball-mill was achieved.
Unusual high-cluster (Cu9) cage phenylsilsesquioxanes were obtained via complexation of in situ CuII,Na-silsesquioxane species formed with phenanthroline and neocuproine. In the first case, phenanthroline, acting as "a silent ligand" (not participating composition final product), favors formation an unprecedented cagelike phenylsilsesquioxane Cu9Na6 nuclearity, 1. second neocuproine ligands withdraws two Cu ions from metallasilsesquioxane matrix, producing cationic fragments...
Abstract A series of four unprecedented heterometallic metallagermsesquioxanes were synthesized. Their cage‐like architectures have a unique type molecular topology consisting the hexairon oxo {Fe 6 O 19 } core surrounded in triangular manner by three cyclic germoxanolates [PhGe(O)O] 5 . This structural organization induces antiferromagnetic interactions between Fe III ions through oxygen atoms. Evaluated for this first time catalysis, these compounds showed high catalytic activity oxidation...