A5101518977- Agriculture and Rural Development Research
- Education, sociology, and vocational training
- French Urban and Social Studies
- Wheat and Barley Genetics and Pathology
- Sphingolipid Metabolism and Signaling
- Aging, Elder Care, and Social Issues
- Genetics and Plant Breeding
- Social Policies and Family
- Social Sciences and Governance
- Genetic and phenotypic traits in livestock
- Antenna Design and Analysis
- Power Line Communications and Noise
- Antenna Design and Optimization
- Optimal Experimental Design Methods
- Multiple Sclerosis Research Studies
- African Botany and Ecology Studies
- Genetic diversity and population structure
- Plant Physiology and Cultivation Studies
- Evolution and Genetic Dynamics
- Drug Transport and Resistance Mechanisms
- Horticultural and Viticultural Research
- Statistical Methods in Clinical Trials
- Genetic Mapping and Diversity in Plants and Animals
- Fungal Plant Pathogen Control
- Genomics and Phylogenetic Studies
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Université Paris-Saclay
2019-2025
CEA LIST
2014-2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2003-2023
Novartis (Switzerland)
2010-2022
Mathématiques et Informatique Appliquées du Génome à l'Environnement
2005-2020
Espaces et Sociétés
1999-2019
Mathématiques et Informatique Appliquées
2006-2014
Département Mathématiques et Informatique Appliquées
2006-2013
Novartis Institutes for BioMedical Research
2011-2013
Abstract Background DNA barcoding aims to assign individuals given species according their sequence at a small locus, generally part of the CO1 mitochondrial gene. Amongst other issues, this raises question how deal with within-species genetic variability and potential transpecific polymorphism. In context, we examine several assignation methods belonging two main categories: (i) phylogenetic (neighbour-joining PhyML) that attempt account for genealogical framework evolution (ii) supervised...
<h3>Objective</h3> No Crohn's disease (CD) molecular maker has advanced to clinical use, and independent lines of evidence support a central role the gut microbial community in CD. Here we explore feasibility extracting bacterial protein signals relevant CD, by interrogating myriads intestinal proteomes from small number patients healthy controls. <h3>Design</h3> We first developed validated workflow—including extraction communities, two-dimensional difference gel electrophoresis (2D-DIGE),...
Abstract Owing to the growing recognition of gut microbiota as a main partner human health, we are expecting that number indications for fecal transplantation (FMT) will increase. Thus, there is an urgent need standardization entire process transplant production. This study provides complete standardized procedure prepare and store live ready-to-use transplants meet standard requirements good practices applied use in pharmaceutical industry. We show that, if time before transformation would...
Fingolimod, a first-in-class oral sphingosine 1-phosphate receptor (S1PR) modulator, is approved in many countries for relapsing-remitting multiple sclerosis, at once-daily 0.5-mg dose. A reduction peripheral lymphocyte count an expected consequence of the fingolimod mechanism S1PR modulation. The authors investigated if this pharmacodynamic effect impacts humoral and cellular immunogenicity. In double-blind, parallel-group, 4-week study, 72 healthy volunteers were randomized to steady...
Management of pesticide resistance is a major issue in modern agricultural systems, particularly the context broader challenge reducing use. However, such management must be adapted to dynamics, which remains challenging predict due its dependence on many biological traits pests, interactions with environment and We retrospectively studied evolution reported resistances four modes action (benzimidazoles, quinone outside inhibitors, sterol demethylation inhibitors succinate dehydrogenase...
Participatory plant breeding (PPB) is aimed at developing varieties adapted to agroecologically-based systems. In PPB, selection decentralized in the target environments, and relies on collaboration between farmers, farmers' organisations researchers. By doing so, evaluation of new genotypes takes genotype x environment (GxE) interactions into account select for specific adaptation. many cases, there little overlap among assessed from farm because farmers participating a PPB project choose...
The selection pressure experienced by organisms often varies across the species range. It is hence crucial to characterise link between environmental spatial heterogeneity and adaptive dynamics of or populations. We address this issue studying phenotypic evolution a metapopulation using an approach. singular strategy found be mean optimal phenotypes in each habitat with larger weights for habitats present large well connected patches. presence clusters facilitate specialisation increase both...
Summary In modern cropping systems, the near‐universal use of plant protection products selects for resistance in pest populations. The emergence and evolution this adaptive trait threaten treatment efficacy. We identified determinants fungicide quantified their effects at a large spatiotemporal scale. focused on Zymoseptoria tritici , which causes leaf blotch wheat. Phenotypes qualitative or quantitative to various fungicides were monitored annually, from 2004 2017, about 70 sites...
Fingolimod has a novel mechanism of action in multiple sclerosis, being first-in-class sphingosine 1-phosphate receptor modulator. Because potential risk fetal toxicity based on animal studies, women childbearing are advised to take effective contraceptive measures during and for 2 months after stopping fingolimod therapy. To assess whether the efficacy combined oral (OC) could be compromised therapy, steady-state, drug-drug interaction study with ethinylestradiol/levonorgestrel was...
ABSTRACT Decentralized participatory plant breeding (PPB) is a method for creating new varieties adapted to agroecology based systems. Selection decentralized in the target environments and relies on collaboration between farmers, Non Governmental Organizations (NGOs), researchers. In wheat PPB project studied, decentralization was extensive as each farmer participating performed selection experiment his farm. This led unbalanced designs with few residual degrees of freedom available...
Treatments are often assessed in small experimental units to economize on resources. Treatment differences for the large used practice may then be poorly estimated because of interference. Using prior information treatments, designs proposed which control interference by ensuring that treatments neighboring similar. Interference ignored analysis. Two types considered: block based concurrence same block, and neighbor take account adjacent units.
Fingolimod, a sphingosine 1-phosphate receptor modulator, is the first oral disease modifying therapy approved for treatment of relapsing multiple sclerosis. The aim this double-blind, placebo-controlled study was to evaluate effect fingolimod on cerebral blood flow, platelet function and macular thickness in healthy volunteers.
Abstract Fingolimod, a first‐in‐class sphingosine 1‐phosphate receptor modulator, is the first approved oral therapy for relapsing multiple sclerosis (MS). While treatment initiation of clinical dose fingolimod (0.5 mg) does not affect pulmonary function, supra‐therapeutic doses (≥5.0 increased airway resistance. The aim this double‐blind, placebo‐controlled, parallel group, 10‐day study was to measure effect on function in otherwise healthy patients with moderate asthma. Subjects (n = 36)...
In the context of touch-based object localisation, solving problem "where to sense next" is a challenging task due curse dimensionality related belief-state reasoning. We present constrained optimisation scheme that computes next best action maximising trade off between (i) localisation information gain, (ii) time required for its computation, and (iii) motion-execution time. This allows robot programmer have deterministic influence on length every sensing action. The proposed methodology...
Removal/reinstallation of all Test Blanket System (TBS) equipment present in the Port Cell is required during ITER Long Term Shutdown. TBS shall be designed so that occupational radiation exposure can As Low Reasonably Achievable (ALARA) over life plant to follow Policy. The expected level this area still allows performing maintenance tasks hands-on. However, cumulated dose could significant for operators. Classical Dose Reduction Measure (DRM) deploy Remote Handling systems. Consequently,...
Interplot interference is known to be potentially a major source of bias in cultivar trials several plant species, but there are few published results concerning grain maize ( Zea mays L.) France. Two series field experiments were conducted the North and South France from 1994 1996 quantify compare methods control. Each experiment typically consisted reference trial with two or three unharvested rows on each side plot, four‐row‐plot one row two‐row‐plot trial. Trials had seven cultivars...