Hervé M. Blottière
A5081742118- Gut microbiota and health
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Cancer Research and Treatments
- Food composition and properties
- Immune Cell Function and Interaction
- Microbial Metabolites in Food Biotechnology
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Biochemical Analysis and Sensing Techniques
- Monoclonal and Polyclonal Antibodies Research
- Gastrointestinal motility and disorders
- Oral microbiology and periodontitis research
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Nutritional Studies and Diet
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Bone and Dental Protein Studies
- Advanced Chemical Sensor Technologies
PhysioPathologie des Adaptations Nutritionnelles
2022-2025
Microbiologie de l’alimentation au service de la santé
2015-2025
AgroParisTech
2015-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Université Paris-Saclay
2016-2025
Nantes Université
1991-2025
Technologies pour la Santé
2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2024
CEA Paris-Saclay
2024
Institut de Biologie et Technologies
2024
A decrease in the abundance and biodiversity of intestinal bacteria within dominant phylum Firmicutes has been observed repeatedly Crohn disease (CD) patients. In this study, we determined composition mucosa-associated microbiota CD patients at time surgical resection 6 months later using FISH analysis. We found that a reduction major member Firmicutes, Faecalibacterium prausnitzii, is associated with higher risk postoperative recurrence ileal CD. lower proportion F. prausnitzii on resected...
The aim of this paper is to review the evidence association between energy balance and obesity. In December 2015, International Agency for Research on Cancer (IARC), Lyon, France convened a Working Group international experts regarding obesity, with focus Low Middle Income Countries (LMIC). global epidemic obesity double burden, in LMICs, malnutrition (coexistence undernutrition overnutrition) are both related poor quality diet unbalanced intake. Dietary patterns consistent traditional...
Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake insulin secretion, are translational interest field obesity diabetes. PYY production is highest enteroendocrine cells located distal intestine, mirroring sites where high concentrations short chain fatty acids (SCFAs) produced by gut microbiota. We show here that propionate butyrate strongly increased expression but not GCG human cell line intestinal primary culture models. The effect...
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in MetaCardis cohort three European countries have elevated serum imidazole levels. Furthermore, levels were increased low bacterial gene richness Bacteroides 2 enterotype, previously been associated obesity. The enterotype was also...
Abstract The intestinal microbiota contributes to the global wellbeing of their host by fundamental role in induction and maintenance a healthy immune system. Commensal bacteria shape mucosal system influencing proportion activation state anti-inflammatory regulatory T cells (Treg) metabolites that are still only partially unravelled. Microbiota members such as Clostridiales provide transforming growth factor β (TGFβ)-rich environment promotes accumulation Treg gut. epithelial (IECs) take...
The mucus layer covering the gastrointestinal mucosa is considered first line of defense against aggressions arising from luminal content. It mainly composed high molecular weight glycoproteins called mucins. Butyrate, a short-chain fatty acid produced during carbohydrate fermentation, has been shown to increase mucin secretion. aim this study was test 1) whether butyrate regulates expression various MUC genes, which are coding for protein backbones mucins, and 2) effect depends on status as...
Short-chain fatty acids (SCFAs) are recognized as the major anions of large intestinal content in humans, but their effect on colonic motility is controversial. This study explores motor SCFAs and mechanisms rat. Colonic (electromyography) transit time (plastic markers) were measured conscious rats while infused into colon, either alone or after administration neural antagonists immunoneutralization circulating polypeptide YY (PYY). SCFA-induced PYY release was by RIA then simulated infusing...
Streptococcus salivarius is one of the first colonizers human oral cavity and gut after birth therefore may contribute to establishment immune homeostasis regulation host inflammatory responses. The anti-inflammatory potential S. was evaluated in vitro on intestinal epithelial cells peripheral blood mononuclear cells. We show that live strains inhibited activation NF-κB pathway also demonstrate JIM8772 strain significantly inflammation severe moderate colitis mouse models. These vivo...
Abstract The ligand activated transcription factor, aryl hydrocarbon receptor (AhR) emerged as a critical regulator of immune and metabolic processes in the gastrointestinal tract. In gut, main source AhR ligands derives from commensal bacteria. However, many reported microbiota-derived have been restricted to indolyl metabolites. Here, by screening bacteria supernatants on an reporter system expressed human intestinal epithelial cell line (IEC), we found that short chain fatty acid (SCFA)...
Commensal bacteria are crucial for the development and maintenance of a healthy immune system therefore contributing to global wellbeing their host. A wide variety metabolites produced by commensal influencing host health but characterisation multiple molecular mechanisms involved in host-microbiota interactions is still only partially unravelled. The intestinal epithelial cells (IEC) take central part dialogue inducing first microbial-derived signals. Amongst numerous effector molecules...
Extracellular vesicles (EVs) are nanometric spherical structures involved in intercellular communication, whose production is considered to be a widespread phenomenon living organisms. Bacterial EVs associated with several processes that include survival, competition, pathogenesis, and immunomodulation. Among probiotic Gram-positive bacteria, some Propionibacterium freudenreichii strains exhibit anti-inflammatory activity, notably via surface proteins such as the surface-layer protein B...