A5035651551- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Use and Resistance
- Evolution and Genetic Dynamics
- Bacterial biofilms and quorum sensing
- Bacterial Genetics and Biotechnology
- Gut microbiota and health
- Cystic Fibrosis Research Advances
- Genomics and Phylogenetic Studies
- Streptococcal Infections and Treatments
- Bacteriophages and microbial interactions
- Bacterial Infections and Vaccines
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Probiotics and Fermented Foods
- Mycobacterium research and diagnosis
- Infections and bacterial resistance
- Escherichia coli research studies
- Listeria monocytogenes in Food Safety
- Clostridium difficile and Clostridium perfringens research
Instituto Cajal
2016-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2016-2025
Instituto Ramón y Cajal de Investigación Sanitaria
2016-2025
Hospital Universitario Ramón y Cajal
2016-2025
Instituto de Salud Carlos III
2002-2024
Centre for Biomedical Network Research on Rare Diseases
2017-2024
Medical Research Network
2023-2024
Centro de Investigación Biomédica en Red
2012-2024
Health Net
2021-2023
Hospital Universitari i Politècnic La Fe
2022
Listeria monocytogenes is a food-borne pathogen with high mortality rate that has also emerged as paradigm for intracellular parasitism. We present and compare the genome sequences of L. (2,944,528 base pairs) nonpathogenic species, innocua (3,011,209 pairs). found large number predicted genes encoding surface secreted proteins, transporters, transcriptional regulators, consistent ability both species to adapt diverse environments. The presence 270 149 strain-specific (clustered in 100 63...
Extended-spectrum beta-lactamases (ESBLs) have been increasingly reported in Europe since their first description 1983. During the 1990s, they were described mainly as members of TEM- and SHV-beta-lactamase families Klebsiella pneumoniae causing nosocomial outbreaks. Nowadays, are mostly found Escherichia coli that cause community-acquired infections with increasing frequency contain CTX-M enzymes. Dissemination specific clones or clonal groups epidemic plasmids community settings has main...
Abstract We analyzed 43 CTX-M-15–producing Escherichia coli isolates and 6 plasmids encoding the blaCTX-M-15 gene from Canada, India, Kuwait, France, Switzerland, Portugal, Spain. Most belonged to phylogroups B2 (50%) D (25%). An EC-B2 strain of clonal complex sequence type (ST) 131 was detected in all countries; other corresponded ST28, ST405, ST354, ST695 specific areas. EC-D strains were clonally unrelated but 3 countries ST405. All CTX-M-15 IncFII group with overrepresentation...
It has been widely assumed that the ecological function of antibiotics in nature is fighting against competitors. This made them a good example Darwinian struggle-for-life microbial world. Based on this idea, it also believed antibiotics, even at subinhibitory concentrations, reduce virulence bacterial pathogens. Herein, using combination genomic and functional assays, we demonstrate specific (namely tobramycin, tetracycline, norfloxacin) concentrations trigger expression determinants...
Vancomycin-resistant enterococci (VRE) have caused hospital outbreaks worldwide, and the vancomycin-resistance gene (vanA) has crossed genus boundaries to methicillin-resistant Staphylococcus aureus. Spread of VRE, therefore, represents an immediate threat for patient care creates a reservoir mobile resistance genes other, more virulent pathogens. Evolutionary genetics, population structure, geographic distribution 411 VRE vancomycin-susceptible Enterococcus faecium isolates, recovered from...
Abstract Vancomycin-resistant enterococci (VRE) have caused hospital outbreaks worldwide, and the vancomycin-resistance gene (vanA) has crossed genus boundaries to methicillin-resistant Staphylococcus aureus. Spread of VRE, therefore, represents an immediate threat for patient care creates a reservoir mobile resistance genes other, more virulent pathogens. Evolutionary genetics, population structure, geographic distribution 411 VRE vancomycin-susceptible Enterococcus faecium isolates,...
The role of listeriolysin O in the intracellular multiplication Listeria monocytogenes and, therefore, its pathogenicity was questioned through a genetic complementation study. A nonhemolytic mutant generated by inserting single copy transposon Tn917 bacterial chromosome. This insertion localized DNA sequence analysis hlyA, gene coding for O. As another that we previously characterized, this avirulent mouse. It transformed with plasmid carrying only able to replicate L. monocytogenes, and...
ABSTRACT A multilocus sequence typing (MLST) scheme based on seven housekeeping genes was used to investigate the epidemiology and population structure of Enterococcus faecalis . MLST 110 isolates from different sources geographic locations revealed 55 types that grouped into four major clonal complexes (CC2, CC9, CC10, CC21) by use eBURST. Two these complexes, CC2 are particularly fit in hospital environment, as includes previously described BVE complex identified an alternative CC9...
Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that antibiotic of bacterial pathogens mainly the consequence cellular impermeability and activity efflux pumps. However, analysis transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows phenotype emerges from action numerous proteins all functional categories. Mutations some genes make P. more susceptible thereby represent new targets. other resistant therefore...