A5045015403- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical and Antibiotic Environmental Impacts
- Enterobacteriaceae and Cronobacter Research
- Bacterial biofilms and quorum sensing
- Genomics and Phylogenetic Studies
- Streptococcal Infections and Treatments
- Bacteriophages and microbial interactions
- Probiotics and Fermented Foods
- Gut microbiota and health
- Antibiotic Use and Resistance
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Bacterial Genetics and Biotechnology
- Evolution and Genetic Dynamics
- Infective Endocarditis Diagnosis and Management
- Infections and bacterial resistance
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Antibiotics Pharmacokinetics and Efficacy
- Microbial Metabolism and Applications
- Vibrio bacteria research studies
- Plant Pathogenic Bacteria Studies
Instituto Ramón y Cajal de Investigación Sanitaria
2016-2025
Instituto Cajal
2016-2025
Centro de Investigación Biomédica en Red
2012-2025
Hospital Universitario Ramón y Cajal
2015-2024
Centre for Biomedical Network Research on Rare Diseases
2017-2024
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2014-2024
Instituto de Salud Carlos III
2014-2024
University of Birmingham
2024
European Society of Clinical Microbiology and Infectious Diseases
2024
Medical Research Network
2023
Extended-spectrum beta-lactamases (ESBLs) have been increasingly reported in Europe since their first description 1983. During the 1990s, they were described mainly as members of TEM- and SHV-beta-lactamase families Klebsiella pneumoniae causing nosocomial outbreaks. Nowadays, are mostly found Escherichia coli that cause community-acquired infections with increasing frequency contain CTX-M enzymes. Dissemination specific clones or clonal groups epidemic plasmids community settings has main...
Abstract We analyzed 43 CTX-M-15–producing Escherichia coli isolates and 6 plasmids encoding the blaCTX-M-15 gene from Canada, India, Kuwait, France, Switzerland, Portugal, Spain. Most belonged to phylogroups B2 (50%) D (25%). An EC-B2 strain of clonal complex sequence type (ST) 131 was detected in all countries; other corresponded ST28, ST405, ST354, ST695 specific areas. EC-D strains were clonally unrelated but 3 countries ST405. All CTX-M-15 IncFII group with overrepresentation...
Nowadays, six types of acquired vancomycin resistance in enterococci are known; however, only VanA and to a lesser extent VanB widely prevalent. Various genes encode these typically associated with mobile genetic elements which allow spread clonally laterally. The major reservoir is Enterococcus faecium; vancomycin-resistant faecalis still rare. Population analysis E. faecium has revealed distinct subpopulation hospital-acquired strain types, can be differentiated by molecular typing methods...
Vancomycin-resistant enterococci (VRE) have caused hospital outbreaks worldwide, and the vancomycin-resistance gene (vanA) has crossed genus boundaries to methicillin-resistant Staphylococcus aureus. Spread of VRE, therefore, represents an immediate threat for patient care creates a reservoir mobile resistance genes other, more virulent pathogens. Evolutionary genetics, population structure, geographic distribution 411 VRE vancomycin-susceptible Enterococcus faecium isolates, recovered from...
Abstract Vancomycin-resistant enterococci (VRE) have caused hospital outbreaks worldwide, and the vancomycin-resistance gene (vanA) has crossed genus boundaries to methicillin-resistant Staphylococcus aureus. Spread of VRE, therefore, represents an immediate threat for patient care creates a reservoir mobile resistance genes other, more virulent pathogens. Evolutionary genetics, population structure, geographic distribution 411 VRE vancomycin-susceptible Enterococcus faecium isolates,...
ABSTRACT A multilocus sequence typing (MLST) scheme based on seven housekeeping genes was used to investigate the epidemiology and population structure of Enterococcus faecalis . MLST 110 isolates from different sources geographic locations revealed 55 types that grouped into four major clonal complexes (CC2, CC9, CC10, CC21) by use eBURST. Two these complexes, CC2 are particularly fit in hospital environment, as includes previously described BVE complex identified an alternative CC9...
ABSTRACT The occurrence of extended-spectrum β-lactamase (ESBL)-producing isolates has increased worldwide. Fecal carriage ESBL-producing mainly been detected in nosocomial outbreaks, and few studies have evaluated fecal during nonoutbreak situations among patients the community. We studied prevalence ESBLs 1,239 samples from 849 (64.1% whom were ambulatory) 1991 compared data with those obtained 2003 for 400 386 (75.9% 108 independent healthy volunteers. Samples diluted saline cultured two...
The presence of vancomycin-resistant enterococci (VRE) was looked for in fecal samples from 104 healthy volunteers (3 with hospital exposure), 100 selected hospitalized patients, and various environmental sources (44 commercial chickens, 5 farm-raised 3 turkeys, 2 chicken farm lagoon slurries). Five probiotic preparations were also studied. No VRE vanA or vanB genes isolated the without exposure, sources, preparations. found stools 16% high-risk patients one volunteer contact. All examined...
Journal Article Incidence of Hemolysin, Gelatinase, and Aggregation Substance among Enterococci Isolated from Patients with Endocarditis Other Infections Feces Hospitalized Community-Based Persons Get access Teresa M. Coque, Coque Search for other works by this author on: Oxford Academic PubMed Google Scholar Jan E. Patterson, Patterson James Steckelberg, Steckelberg Barbara Murray Reprints or correspondence: Dr. Murray, University Texas Medical School, Center Infectious Diseases, 6431...
ABSTRACT Over a 12-year period (1989 to 2000), 159 Klebsiella pneumoniae isolates harboring extended-spectrum β-lactamases (ESBLs) (4.8% of the total number K. obtained) were recovered from 58 patients, who mainly hospitalized in intensive care and surgery units. For 62 representative 31 clonal types TEM-4 ( n = 5), SHV-2 7), SHV2a 4), SHV-5 1), CTX-M-10 13), or CTX-M-9 1) identified by pulsed-field gel electrophoresis. This is first report document presence β-lactamase . These previously...
The contribution of integrons to the dissemination extended-spectrum beta-lactamases (ESBL) was analyzed on all ESBL-producing Escherichia coli isolates from 1988 2000 at Ramon y Cajal Hospital. We studied 133 E. pulsed-field gel electrophoresis types: (i) 52 clinical strains (C-ESBL) (16 TEM, 9 SHV, 21 CTX-M-9, 1 CTX-M-14, and 5 CTX-M-10); (ii) 43 non-ESBL blood (C-nESBL); (iii) 38 fecal healthy volunteers (V-nESBL). Class were more common among C-ESBL (67%) than C-nESBL (40%) or V-nESBL...
ABSTRACT This article reports the spread of bla KPC-2 in Sao Paulo and Rio de Janeiro states, facilitated by globally K. pneumoniae clonal complex 258 (CC258) clones (ST258, ST11, ST437) a diversity plasmids (IncFII, IncN, IncL/M, two untypeable carrying Tn 4401 or b) successfully disseminated among species Enterobacteriaceae ( Enterobacter cloacae , Serratia marcescens Citrobacter freundii ). It also constitutes first description sequence type (ST258) Brazil, which was associated with...