A5074278103- Evolution and Genetic Dynamics
- Leptospirosis research and findings
- Microbial Metabolic Engineering and Bioproduction
- Viral Infections and Vectors
- Zoonotic diseases and public health
- Evolutionary Game Theory and Cooperation
- CRISPR and Genetic Engineering
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Cyclone Separators and Fluid Dynamics
- Gut microbiota and health
- Mathematical and Theoretical Epidemiology and Ecology Models
- Bioinformatics and Genomic Networks
VetAgro Sup
2024
Université Claude Bernard Lyon 1
2024
Université Paris Cité
2018-2022
Inserm
2018-2022
Université Sorbonne Paris Nord
2021
Sorbonne Université
2021
Microbiologie de l’alimentation au service de la santé
2016-2019
ESPCI Paris
2018
Université Paris Sciences et Lettres
2018
Délégation Paris 7
2018
Abstract Owing to the growing recognition of gut microbiota as a main partner human health, we are expecting that number indications for fecal transplantation (FMT) will increase. Thus, there is an urgent need standardization entire process transplant production. This study provides complete standardized procedure prepare and store live ready-to-use transplants meet standard requirements good practices applied use in pharmaceutical industry. We show that, if time before transformation would...
Our ability to predict the impact of mutations on traits relevant for disease and evolution remains severely limited by dependence their effects genetic background environment. Even when molecular interactions between genes are known, it is unclear how these translate organism-level alleles. We therefore characterized interplay environmental dependencies in determining fitness quantifying ~4000 expression variants two metabolic genes, starting from various environmentally modulated levels....
Abstract Background Leptospirosis is a zoonotic disease. It particularly prevalent in tropical countries and has major consequences for human animal health. In Benin, the disease's epidemiology remains poorly understood, especially livestock, which data are lacking. Objectives To characterise Leptospira seroprevalence locally circulating serogroups livestock from Cotonou to estimate prevalence of renal carriage cattle. Methods We conducted cross‐sectional study February 2020 during were...
Abstract Epistasis affects genome evolution together with our ability to predict individual mutation effects. The mechanistic basis of epistasis remains, however, largely unknown. To quantify and better understand interactions between fitness-affecting mutations, we focus on a 11 amino-acid α-helix the protein β-lactamase TEM-1, build comprehensive library more than 15,000 double mutants. Analysis growth rates these mutants shows pervasive epistasis, which can be explained by non-linear...
Abstract Our ability to predict the impact of mutations on traits relevant for disease and evolution remains severely limited by dependence their effects genetic background environment. Even when molecular interactions between genes are known, it is unclear how these translate organism-level alleles. We therefore characterized interplay environmental dependencies in determining fitness quantifying ~4,000 expression variants two metabolic genes, different environments. detect a remarkable...
Abstract Epistasis affects genome evolution together with our ability to predict individual mutation effects. The mechanistic basis of epistasis remains, however, largely unknown. To quantify and better understand interactions between fitness-affecting mutations, we focus on a 11 amino-acid α-helix the protein β-lactamase TEM-1, build comprehensive library more than 15,000 double mutants. Analysis growth rates these mutants shows pervasive epistasis, which can be explained by non-linear...