A5067894013- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Transplantation: Methods and Outcomes
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Vasculitis and related conditions
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Infective Endocarditis Diagnosis and Management
- Immune cells in cancer
- Pain Mechanisms and Treatments
- Immune Response and Inflammation
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Gut microbiota and health
- RNA modifications and cancer
- Sexual function and dysfunction studies
- Medical and Biological Ozone Research
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- RNA Interference and Gene Delivery
- Organ Transplantation Techniques and Outcomes
- Pulmonary Hypertension Research and Treatments
- Mycobacterium research and diagnosis
- Venous Thromboembolism Diagnosis and Management
- Adenosine and Purinergic Signaling
Medical University of Vienna
2019-2024
CeMM Research Center for Molecular Medicine
2021
Austrian Academy of Sciences
2021
Vienna General Hospital
2020
Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of abdominal aortic aneurysm (AAA), located adventitia and intraluminal thrombus. We compared therapeutic potential targeting upstream or downstream effector molecules NET formation 2 murine AAA models based on angiotensin II peri-adventitial elastase application. In both models, NETs were detected formed aneurysms at treatment start. Although inhibitors failed model, they prevented progression II–induced with thrombus,...
Postoperative pain affects most patients after major surgery and can transition to chronic pain. The considerable side effects limited efficacy of current treatments underline the need for new therapeutic options. We observed increased amounts metabolites BH4 serotonin skin injury. Mast cells were primary postoperative sources Gch1 , rate-limiting enzyme in synthesis, itself an obligate cofactor production by tryptophan hydroxylase (Tph1). Mice deficient mast or cell–specific Tph1 showed...
Neutrophils release their chromatin into the extracellular space upon activation. These web-like structures are called neutrophil traps (NETs) and have potent prothrombotic proinflammatory properties. In ST-elevation myocardial infarction (STEMI), NETs correlate with increased infarct size. The interplay of neutrophils monocytes impacts cardiac remodeling. Monocyte subsets classified as classical, intermediate non-classical monocytes. present study, in vitro stimulation led to an increase...
Abstract Aims Extracellular chromatin and deoxyribonuclease (DNase) have been identified as important players of thrombosis, inflammation, homeostasis in a murine model. We previously demonstrated that activated neutrophils release neutrophil extracellular traps (NETs) at the culprit site ST-elevation myocardial infarction (STEMI), which significantly contribute to burden, are associated with larger infarcts. To understand correlation between activation, chromatin, infarct size (IS), we...
Abstract Background and Aims Neutrophil extracellular traps (NETs) trigger atherothrombosis during acute myocardial infarction (AMI), but mechanisms of induction remain unclear. Levels vesicles (EV) carrying oxidation-specific epitopes (OSE), which are targeted by specific natural immunoglobulin M (IgM), increased at the culprit site in AMI. This study investigated EV as inducers NETosis assessed inhibitory effect anti-OSE–IgM this process. Methods Blood from peripheral ST-segment elevation...
Rationale Lung transplantation is the ultimate treatment option for patients with end-stage respiratory diseases but bears highest mortality rate among all solid organ transplantations due to chronic lung allograft dysfunction (CLAD). The mechanisms leading CLAD remain elusive an insufficient understanding of complex post-transplant adaptation processes. Objectives To better understand these processes after and investigate their association future changes in function. Methods We performed...
(1) Background: An unhealthy lifestyle is a significant contributor to the development of chronic diseases. Physical activity can benefit primary and secondary prevention. Higher DNase associated with favourable outcomes after cardiovascular (CV) events. In this study, we aimed investigate influence consequent endurance exercise on activity. (2) Methods: 98 subjects at least one CV risk factor but physical ability perform training were included. Individuals performed bicycle stress test...
Postoperative pain affects most patients after major surgery and can transition to chronic pain. Here, we discovered that postoperative hypersensitivity correlated with markedly increased local levels of the metabolite BH4. Gene transcription reporter mouse analyses skin injury identified neutrophils, macrophages mast cells as primary sources GTP cyclohydrolase-1 (
Abstract Introduction Extracellular cell-free DNA (cfDNA) originates from various biological processes, including cell turnover, apoptosis, necrosis, NETosis, and other forms of death. In healthy individuals, highly fragmented cfDNA is elevated in the bloodstream due to infection, cancer, inflammation thrombosis. thrombotic vascular diseases, neutrophils release elongated, high-molecular-weight with bioactive prothrombotic properties a process termed NETosis. Circulating nucleases are...
Abstract Introduction Thoracic aortic aneurysm (TAA) is a rare but severe cardiovascular disease. The condition often goes undiagnosed, increasing the risk of acute events. It characterized by medial degeneration, caused neutrophils infiltrating tissue. Neutrophils can form proinflammatory and prothrombotic neutrophil extracellular traps (NETs), promoting disease progression. Purpose Recently, NETs abdominal (AAA) were linked, while their effects on TAA development progression remain...
Abstract Background Neutrophil extracellular traps (NETs) are critical mediators of thromboinflammation during acute myocardial infarction (AMI). However, triggers and signalling pathways NETosis in AMI remain incompletely understood. Levels vesicles (EV) carrying oxidation-specific epitopes (OSE) originating from lipid peroxidation increased at the culprit site AMI. Importantly, natural IgM antibodies with specificity for OSE, such as malondialdehyde (MDA), have been shown to modulate...
Degenerative aortic valve stenosis is an inflammatory process that resembles atherosclerosis. Neutrophils release their DNA upon activation and form neutrophil extracellular traps (NETs), which are present on degenerated valves. NETs correlate with pressure gradients in severe stenosis. Transcatheter replacement (TAVR) established treatment option for Bioprosthetic deterioration promoted by inflammatory, fibrotic thrombotic processes limits outcome. Deoxyribonuclease a natural counter...