A5082792007- Fetal and Pediatric Neurological Disorders
- Transplantation: Methods and Outcomes
- Immune Response and Inflammation
- Mast cells and histamine
- Advanced X-ray and CT Imaging
- Prenatal Screening and Diagnostics
- Allergic Rhinitis and Sensitization
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Food Allergy and Anaphylaxis Research
- RNA Interference and Gene Delivery
- Hemoglobinopathies and Related Disorders
- Congenital Diaphragmatic Hernia Studies
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Radiation Dose and Imaging
- Thermal Regulation in Medicine
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Cerebrospinal fluid and hydrocephalus
- Hematopoietic Stem Cell Transplantation
- Sarcoma Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
Medical University of Vienna
2018-2024
Austrian Academy of Sciences
2018-2022
CeMM Research Center for Molecular Medicine
2018-2022
University of Vienna
2020
Environmental microbial triggers shape the development and functionality of immune system. Alveolar macrophages (AMs), tissue-resident lungs, are in constant direct contact with inhaled particles microbes. Such exposures likely impact AM reactivity to subsequent challenges by immunological imprinting mechanisms referred as trained immunity. Here, we investigated whether a ubiquitous compound has potential induce training vivo. We discovered that intranasal exposure ambient amounts...
Prior work has shown improved image quality for photon-counting detector (PCD) CT of the lungs compared with energy-integrating CT. A paucity literature PCD using different reconstruction parameters.
To investigate the reproducibility of radiomics features extracted from two-dimensional regions interest (2D ROIs) versus whole lung (3D) ROIs in repeated in-vivo fetal magnetic resonance imaging (MRI) acquisitions.Thirty MRI scans including two axial T2-weighted acquisitions lungs were analysed. 2D (lung at level carina) and 3D (whole lung) manually segmented using ITK-Snap. Ninety-five 2 initial repeat Pyradiomics. Radiomics feature intra-class correlation coefficients (ICC) calculated...
Abstract Objectives To conduct an intrapatient comparison of ultra-low-dose computed tomography (ULDCT) and standard-of-care-dose CT (SDCT) the chest in terms diagnostic accuracy ULDCT intrareader agreement patients with post-COVID conditions. Methods We prospectively included 153 consecutive post-COVID-19 All participants received SDCT additional scan chest. SDCTs were performed standard imaging parameters ULDCTs at a fixed tube voltage 100 kVp (with tin filtration), 50 ref. mAs (dose...
In contrast to their clearly defined roles in allergic diseases, the physiologic functions of Immunoglobulin E antibodies (IgEs) and mast cells (MCs) remain enigmatic. Recent research supports toxin hypothesis, showing that MCs IgE-related type 2 immune responses can enhance host defense against certain noxious substances, including honeybee venom (BV). However, mechanisms by which interfere with BV toxicity are unknown. this study, we assessed role IgE MC products MC-mediated detoxification.
Rationale Lung transplantation is the ultimate treatment option for patients with end-stage respiratory diseases but bears highest mortality rate among all solid organ transplantations due to chronic lung allograft dysfunction (CLAD). The mechanisms leading CLAD remain elusive an insufficient understanding of complex post-transplant adaptation processes. Objectives To better understand these processes after and investigate their association future changes in function. Methods We performed...
To identify brain edema in fetuses with Chiari II malformation using a multiparametric approach including structural T2-weighted, diffusion tensor imaging (DTI) metrics, and MRI-based radiomics.
Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multiorgan failure. Therapeutic options prevent sepsis-associated immunopathology remain scarce. Here, we established mouse model of long-lasting disease tolerance during severe sepsis, manifested diminished immunothrombosis organ damage in spite high pathogen burden. We found that both neutrophils B cells emerged as key regulators tissue integrity. Enduring changes the...
Lipocalin 2 (LCN2) is a secreted glycoprotein with roles in multiple biological processes. It contributes to host defense by interference bacterial iron uptake and exerts immunomodulatory functions various diseases. Here, we aimed characterize the function of LCN2 lung macrophages dendritic cells (DCs) using Lcn2-/- mice. Transcriptome analysis revealed strong LCN2-related effects CD103+ DCs during homeostasis, differential regulation antigen processing presentation antiviral immunity...
Early detection of soft tissue sarcoma (STS) recurrence is essential; however, the role and timeline Magnetic resonance imaging (MRI) surveillance are still under debate. The aim this study was to determine whether local (LR) could be identified via clinical examination alone assess MRI morphology primary STS LR.
Alemtuzumab is a monoclonal antibody targeting CD52, used as induction therapy after lung transplantation (LTx). Its engagement produces long-lasting immunodepletion; however, the mechanisms driving cell reconstitution are poorly defined. We hypothesized that miRNAs involved in this process. The expression of set miRNAs, cytokines and co-signaling molecules was measured with RT-qPCR flow cytometry prospectively collected serum samples LTx recipients, alemtuzumab or no therapy. Twenty-six...
Background: The reproducibility of radiomics features extracted from CT and MRI examinations depends on several physiological technical factors. aim was to evaluate the impact contrast agent timing stability using dynamic contrast-enhanced perfusion (dceCT) or (dceMRI) in prostate lung cancers. Methods: Radiomics were dceCT dceMRI images patients with biopsy-proven peripheral cancer (pzPC) non-small cell (NSCLC), respectively. Features that showed significant differences between phases...
Intrauterine transfusions (IUTs) are a life-saving treatment for fetal anemia. However, with each transfusion, iron bypasses uptake regulation through the placenta and accumulates in organs. Unlike other imaging modalities, magnetic resonance (MRI) is capable of non-invasively assessing liver disease and/or organ overload. This study aimed to investigate effects IUTs on MRI findings spleen.
The radiologic evaluation of ongoing myelination is currently limited prenatally. Novel quantitative MR imaging modalities provide relaxometric properties that are linked to myelinogenesis. In this retrospective postmortem study, the capability Synthetic and fingerprinting-derived relaxometry for tracking fetal myelin development was investigated. Moreover, consistency results both approaches analyzed. 26 cases, brain data were available (gestational age range, 15 + 1 32 1; female/male...
To compare unsupervised deep clustering (UDC) to fat fraction (FF) and relative liver enhancement (RLE) on Gd-EOB-DTPA-enhanced MRI distinguish simple steatosis from non-alcoholic steatohepatitis (NASH), using histology as the gold standard.A derivation group of 46 fatty disease (NAFLD) patients underwent 3-T MRI. Histology assessed steatosis, inflammation, ballooning, fibrosis. UDC was trained different texture patterns MR data into 10 distinct clusters per sequence unenhanced T1-...
Abstract Objectives To investigate the advantage of T1-weighted fast fluid-attenuated inversion-recovery MRI sequence without (T1-FFLAIR) and with compressed sensing technology (T1-FFLAIR-CS), which shows improved contrast, over standard used field echo (T1-FFE) for assessment fetal myelination. Materials methods This retrospective single-center study included 115 consecutive brain examinations (63 axial 76 coronal, mean gestational age (GA) 28.56 ± 5.23 weeks, range 19–39 weeks). Two...