A5002860977- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Polyomavirus and related diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Pulmonary Hypertension Research and Treatments
- Trauma Management and Diagnosis
- Organ and Tissue Transplantation Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Respiratory viral infections research
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Tissue Engineering and Regenerative Medicine
- Cystic Fibrosis Research Advances
- Pleural and Pulmonary Diseases
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- Peptidase Inhibition and Analysis
Medical University of Vienna
2016-2025
Universitätsklinik für Chirurgie Wien
2018
Policlinico San Matteo Fondazione
2016
Istituti di Ricovero e Cura a Carattere Scientifico
2016
Torque teno viruses (TTV) are small DNA-viruses, of the genus Alphatorquevirus, whose replication is linked to immune status. TTV load may be an indicator for efficacy IS in lung transplant recipients (LTRs). In a prospective single-center-study 143 LTRs were followed up and tested by quantitative TTV-DNA PCR. Using multivariate Cox-regression contribution TTV-load occurrence severe infections, chronic allograft dysfunction (CLAD), acute cellular rejection (ACR), death was assessed. During...
Extracorporeal photopheresis (ECP) is used by few lung transplant centers to treat chronic allograft dysfunction (CLAD). Although reported results suggest a beneficial effect on CLAD progression, evidence limited single center experiences. The aim of this study analyze outcomes ECP in large multicenter European cohort. primary endpoint was patient survival after initiation ECP. This included 631 patients, 87% suffered from bronchiolitis obliterans syndrome (BOS), and 13% had restrictive...
Objective: To determine the impact of prolonged storage donor lungs at 10°C up to 24h on outcome after lung transplantation. Background: An increasing body evidence suggests as optimal temperature for lungs. A recent study showed that cold ischemic times can be safely expanded >12h when are stored 10°C. However, it is currently unknown how long preserved before they deteriorate in function. Methods: Patients who received a between 11/2020 and 06/2023 transplant programs Toronto, Vienna...
Introduction: Idiopathic pulmonary fibrosis(IPF) is a chronic progressive lung disease that leads to destruction of alveoli and replacement by fibrotic tissue. Metabolic profiling tissue serum from IPF patients has revealed levels tricarboxylic acid (TCA) cycle metabolites such as succinate are altered in with IPF. In our study, we aim evaluate the role its receptor- receptor 1 (SUCNR1) pathogenesis fibrosis, focus on fibroblasts, central cell Methods: SUCNR1 expression was investigated...
Lung transplantation (LuTx) is an established treatment for patients with end-stage lung diseases, however, outcomes are limited by acute and chronic rejection. One aspect that has received increasing attention the role of host’s humoral alloresponse, particularly formation de novo donor-specific antibodies (dnDSAs). The aim this study was to investigate clinical significance transient persistent dnDSAs understand their impact on after LuTx. A retrospective analysis conducted using DSA...
Question addressed by the study The value of induction therapy in lung transplantation is controversial. According to ISHLT, only about 50% patients transplanted within last 10 years received therapy. We reviewed our institutional experience investigate impact on short- and long-term outcomes. Materials/Patients methods Between 2007 2015, 446 with a complete follow-up were included this retrospective analysis. Analysis comprised kidney function, infectious complications, incidence rejection...
Remodelling of the peripheral lung tissue and fibrotic foci are main pathologies idiopathic pulmonary fibrosis (IPF), a disease that is difficult to treat. TGF- β activation fibroblasts indicated as major cause remodelling in IPF resulting fibroblast hyperplasia deposition extracellular matrix. Soluble guanylate cyclase (sGC) stimulators combined with cyclic AMP (cAMP) activators have been reported reduce proliferation matrix other conditions than IPF. Therefore, this drug combination may...
Aim of work was to locate a simple, reproducible protocol for uniform seeding and optimal cellularization biodegradable patch minimizing the risk structural damages its contamination in long-term culture. Two procedures are exploited, namely static on biocompatible patches incubated as free floating (floating conditions) or supported by CellCrownTM insert (fixed engineered porcine bone marrow MSCs (p-MSCs). Scaffold prototypes having specific features with regard pore size, orientation,...
<b><i>Introduction:</i></b> The diagnosis and treatment of antibody-mediated rejection (AMR) after lung transplantation has recently gained recognition within the transplant community. Extracorporeal photopheresis (ECP), currently used to treat chronic allograft dysfunction, modulates various pathways immune system known be involved in AMR. We hypothesize that adding ECP established AMR treatments could prevent rebound donor-specific antibodies (DSA)....
Pulmonary retransplant (ReTx) is considered a controversial procedure. Despite literature reporting outcomes following ReTx, limited data exist in recipients bridged to their ReTx on extracorporeal life support (ECLS). The goal of this study was investigate the first-time by ECLS.We performed retrospective multicentre cohort analysis from 10 centres Europe, Asia and North America. primary outcome overall survival. Risk factors were analysed using Cox regression models.ECLS as bridge 50...
When early acute rejection is adequately controlled, transplanted organs enter a regenerative phase characterized by the presence of recipient monocyte-derived, tissue-reparative macrophages. These cells are responsible for tissue remodeling removing necrotic cells, stimulating revascularization, secreting tissue-trophic factors, and suppressing intragraft allogeneic T cell reactions.1 Ideally, tissues would then return to normal homeostasis stable allograft acceptance be achieved. However,...
A gold standard for esophagus reconstruction is not still available. The present work aims to design a polymer patch combining synthetic polylactide‐ co ‐polycaprolacton and chitosan biopolymers, tailoring properties esophageal tissue characteristics by temperature‐induced precipitation method, get multilayered patches (1L, 2L, 3L). Characterization shows stable (1L 2L) selection of copolymer type, their M w . In vitro investigation the functional in simulated physiologic pathologic...
Abstract Chronic Lung Allograft Dysfunction (CLAD), manifesting as Bronchiolitis Obliterans Syndrome (BOS) or Restrictive (RAS), is the main reason for adverse long-term outcome after Transplantation (LTX). Until now, no specific biomarkers exist to differentiate between CLAD phenotypes. Therefore, we sought find suitable cytokines distinguish BOS, RAS and Azithromycin Responsive (ARAD); reveal potential similarities differences end-stage fibrotic diseases. We observed significantly...