Venous thromboembolism (VTE) is a well-recognized complication of cancer. Laboratory parameters might be useful to assess the VTE risk in patients with The aim this study was investigate D-dimer and prothrombin fragment 1 + 2 (F 2), which reflect activation blood coagulation fibrinolysis, for prediction cancer-associated VTE.In prospective, observational, cohort 821 newly diagnosed cancer or progression disease who did not recently receive chemotherapy, radiotherapy, surgery were enrolled...

Background Systemic activation of hemostasis is frequently observed in cancer patients, even the absence thrombosis. Moreover, this has been implicated tumor progression, angiogenesis and metastatic spread. Increased levels D-dimer, which a degradation product cross-linked fibrin, indicate global fibrinolysis.Design Methods In prospective observational cohort study, we assessed prognostic value D-dimer for overall survival mortality risk 1178 patients included Vienna Cancer Thrombosis Study...

<h3>Context</h3>Although some studies have shown that men are at greater age-specific risk for advanced colorectal neoplasia than women, the age referring patients to screening colonoscopy is independent of sex and usually recommended be 50 years.<h3>Objective</h3>To determine compare prevalence number needed screen (NNS) adenomas, adenomas (AAs), carcinomas (CRCs) different groups in women.<h3>Design, Setting, Patients</h3>Cohort study 44 350 participants a national program over 4-year...

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by intraluminal thrombus organization and fibrous obliteration of arteries. Recently, associated medical conditions such as splenectomy, ventriculoatrial shunt for the treatment hydrocephalus, permanent central intravenous lines, inflammatory bowel disease, osteomyelitis were found to be with development CTEPH. The study aim was define impact these novel risk factors on survival.Between January 1992 December 2006, 181...

Patients with cancer are at increased risk of venous thromboembolism (VTE). Laboratory tests measuring the overall thrombophilic tendency might be useful to assess VTE risk. The aim this study was investigate thrombin generation, a key process in hemostasis, as predictor cancer-associated VTE.The Vienna Cancer and Thrombosis Study (CATS) is prospective observational cohort patients newly diagnosed or progression disease after remission. end point occurrence objectively confirmed symptomatic...

Statistical models are simple mathematical rules derived from empirical data describing the association between an outcome and several explanatory variables. In a typical modeling situation statistical analysis often involves large number of potential variables frequently only partial subject-matter knowledge is available. Therefore, selecting most suitable for model in objective practical manner usually non-trivial task. We briefly revisit purposeful variable selection procedure suggested...

Objective— Patients with cancer are at an increased risk for venous thromboembolism (VTE). Clotting factor VIII activity (FVIII) has been established as of primary and recurrent VTE. We investigated FVIII predictive parameter VTE in patients. Methods Results— The prospective observational Cancer Thrombosis Study (CATS) includes patients newly diagnosed or disease progression, study end point is symptomatic was measured on a Sysmex CA 7000 analyzer. Data 840 (median age: 62 years, 25th to...

<h3>Importance</h3> Type 2 diabetes mellitus and associated chronic kidney disease (CKD) have become major public health problems. Little is known about the influence of diet on incidence or progression CKD among individuals with type diabetes. <h3>Objective</h3> To examine association between (healthy) diet, alcohol, protein, sodium intake, <h3>Design, Setting, Participants</h3> All 6213 without macroalbuminuria from Ongoing Telmisartan Alone in Combination With Ramipril Global Endpoint...

Purpose Patients with cancer are at risk of venous thromboembolism (VTE). Tumor-related factors could help estimate patients' individual for VTE. Currently, only scarce information on the association between tumor grade and VTE is available. We thus evaluated role its Methods The Vienna Cancer Thrombosis Study a prospective, observational cohort study including patients newly diagnosed or progression disease after remission. end point occurrence symptomatic Results Seven hundred forty-seven...

Background and objectives Quantitative data for prediction of incidence progression early CKD are scarce in individuals with type 2 diabetes. Therefore, two risk models were developed after 5.5 years the relative effect predictors ascertained. Design, setting, participants, & measurements Baseline prospective follow-up randomized clinical trials, ONgoing Telmisartan Alone combination Ramipril Global Endpoint Trial (ONTARGET) Outcome Reduction Initial Glargine Intervention (ORIGIN), used as...

Cox's regression model for the analysis of survival data relies on proportional hazards assumption. However, this assumption is often violated in practice and as a consequence average relative risk may be under- or overestimated. Weighted estimation Cox parsimonious alternative which supplies well interpretable effects also case non-proportional hazards. We provide R package coxphw implementing weighted regression. By means two biomedical examples appropriate analyses presence are...

Regression models have been in use for decades to explore and quantify the association between a dependent response several independent variables environmental sciences, epidemiology public health. However, researchers often encounter situations which some exhibit high bivariate correlation, or may even be collinear. Improper statistical handling of this situation will most certainly generate little no practical misleading interpretations. By means two example studies, we demonstrate how...

Summary Atherosclerotic plaque rupture with subsequent mural thrombus formation is considered the main event compromising epicardial flow in acute myocardial infarction (AMI). However, precise mechanisms underlying coronary occlusion are unknown. We compared proteomic profiles of systemic plasma and derived from site patients AMI by two-dimensional gel electrophoresis ELISA. identified a local activation complement system, selective accumulation activator Creactive protein (CRP) downstream...

Quality indicators including cecal intubation rate (CIR) and adenoma detection (ADR) are established. Sex differences of quality observed, but the influence sedation has not been investigated so far. The objective this study is to assess impact on indicators, CIR ADR, according sex.We analyzed data 52,506 screening colonoscopies performed by 196 endoscopists between November 2007 April 2011 Austrian "quality management for colon cancer prevention" program.Sedation did affect polyp (women...

The most commonly used methods to investigate risk factors associated with renal function trajectory over time include linear regression on individual glomerular filtration rate (GFR) slopes, mixed models and generalized estimating equations (GEEs). objective of this study was explain the principles these three discuss their advantages limitations in particular when trajectories are not completely observable due dropout. We generated data from a hypothetical cohort 200 patients chronic...

Advanced cancer is a risk factor for venous thromboembolism. However, lymph node metastases are usually not considered an established factor. In the framework of prospective, observational Vienna Cancer and Thrombosis Study we investigated association between local (N0), regional (N1–3), distant (M1) stages occurrence Furthermore, were specifically interested in relationship stage biomarkers that have been reported to be associated with We followed 832 patients solid tumors median 527 days....