A5048024594- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Transplantation: Methods and Outcomes
- Periodontal Regeneration and Treatments
- Corneal Surgery and Treatments
- Wound Healing and Treatments
- Ocular Surface and Contact Lens
- Renal Transplantation Outcomes and Treatments
- Tissue Engineering and Regenerative Medicine
- Organ Transplantation Techniques and Outcomes
- Neonatal Respiratory Health Research
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Electrospun Nanofibers in Biomedical Applications
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- COVID-19 Clinical Research Studies
- 3D Printing in Biomedical Research
- Acute Lymphoblastic Leukemia research
- Blood transfusion and management
- Platelet Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Polyomavirus and related diseases
- CAR-T cell therapy research
Policlinico San Matteo Fondazione
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Bristol-Myers Squibb (Germany)
2017
Janssen (Belgium)
2017
Amgen (United States)
2017
Mallinckrodt (Ireland)
2017
University of Pavia
2001-2017
Ministero della Salute
2014
Organ Transplantation and Immunology Institute
2001-2005
Policlinico S.Orsola-Malpighi
2001
Hyperimmune plasma from Covid-19 convalescent is a potential treatment for severe Covid-19. We conducted multicenter one arm proof of concept interventional study. Patients with disease moderate-to-severe Acute Respiratory Distress Syndrome, elevated C-reactive Protein and need mechanical ventilation and/or CPAP were enrolled. One to three 250-300 ml unit hyperimmune (neutralizing antibodies titer ≥1:160) administered. Primary outcome was 7-days hospital mortality. Secondary outcomes...
Abstract There is great interest in mesenchymal stromal cells (MSCs) for cell‐therapy and tissue engineering approaches. MSCs are currently expanded vitro the presence of fetal calf serum (FCS); however, FCS raises concerns when used clinical grade preparations. The aim this study was to evaluate whether medium supplemented with platelet‐lysate (PL), already shown promote MSC growth, endowed biological properties appropriate We confirm previously published data showing that either or PL...
Summary. This study aimed to ascertain whether extracorporeal photochemotherapy (ECP) is an effective treatment for paediatric patients with refractory graft‐versus‐host disease (GVHD). From January 1992 December 2000, 77 children (median age 8·6 years) either acute ( n = 33) or chronic 44) GVHD, resistant conventional immunosuppressive therapy, were treated ECP in four Italian hospitals. After ECP, GVHD involving skin, liver and gut responded completely 76%, 60% 75% of respectively. The...
Autologous graft is considered the gold standard of materials; however, this approach still limited due to both small amount tissue that can be collected and reduced cell viability cells obtained. The aim preliminary study was demonstrate efficacy an innovative medical device called Rigeneracons® (CE certified Class I) provide autologous micro‐grafts immediately available used in clinical practice. Moreover, instrument able create enriched progenitors which maintain their regenerative...
BACKGROUND: Extracorporeal photochemotherapy (EPC) has recently been proposed for the treatment of adults with either acute or chronic GVHD. However, data on children given this therapy are scarce. A Phase I‐II study was carried out EPC in experiencing GVHD after allogeneic transplantation HPCs. STUDY DESIGN AND METHODS: Nine patients steroid‐resistant, grade II‐IV and 14 GVHD, all whom had refractory to at least one line treatment, were enrolled analyzed. The median age 10.3 years (range,...
Background Mesenchymal stromal cells are employed in various different clinical settings order to modulate immune response. However, relatively little is known about the mechanisms responsible for their immunomodulatory effects, which could be influenced by both cell source and culture conditions.Design Methods We tested ability of a 5% platelet lysate-supplemented medium support isolation ex vivo expansion mesenchymal from full-term umbilical-cord blood. also investigated...
Extracorporeal photochemotherapy (ECP) is a valid therapeutic option in the treatment of acute and chronic graft-versus-host disease (aGVHD cGVHD, respectively). No standard clinical laboratory criteria response to ECP are available at moment.Clinical variables on 73 pediatric patients with aGVHD (n = 50) cGVHD 23) were correlated survival.An overall (OR) was obtained 34 50 (68%) 16 23 (69.5%) patients. Steroid tapering within 30 days 1.3 mg/kg OR (p 0.004) sole highly significant...
Extracorporeal photopheresis (ECP) is used by few lung transplant centers to treat chronic allograft dysfunction (CLAD). Although reported results suggest a beneficial effect on CLAD progression, evidence limited single center experiences. The aim of this study analyze outcomes ECP in large multicenter European cohort. primary endpoint was patient survival after initiation ECP. This included 631 patients, 87% suffered from bronchiolitis obliterans syndrome (BOS), and 13% had restrictive...
<b><i>Background:</i></b> Extracorporeal photochemotherapy (ECP) for chronic lung allograft dysfunction (CLAD) has been reported as beneficial in a few short-term studies. <b><i>Objectives:</i></b> In this retrospective cohort study on 48 CLAD patients treated by ECP (off-line technique) period of >8 years (compared to 58 controls), we explored potential predictors survival and response. <b><i>Methods:</i></b>...
Human population is facing a revolutionary change in the demographic structure with an increasing number of elderly people requiring unmet need to ensure smooth aging process and dental care certainly important aspect that has be considered. To date, dentistry been conservative transferring scientific models regenerative into clinical practice becoming necessity. The aim this study was characterize differentiation commitment (in vitro) grafting ability vivo) progenitor stem cells obtained...
Abstract Objectives Growth factors contained in platelet α-granules initiate and modulate tissue repair are proposed for the treatment of soft hard-tissue surgical conditions management non-healing wounds. Platelet lysate is a hemoderivative obtained from platelet-rich plasma capable releasing pool growth factors. Many medical techniques have been corneal lesions; these remains problematic healing with standard protocols unattainable. The aim this study was to develop formulations suitable...
Although many trials are currently investigating the safety and efficacy of convalescent plasma (CP) in critically ill COVID-19 patients, there is a paucity ongoing published studies evaluating CP donors' side. This retrospective study reports first Italian experience on selection donations.Patients aged 18-68 years who had recovered from at least 2 weeks previously were recruited between March 18 June 30, 2020 protocol hospitals Pavia Mantova.During period, 494 512 donors judged eligible...
BACKGROUND: Chronic graft‐versus‐host disease (cGVHD) classification has recently been improved by the National Institutes of Health (NIH); patients’ stratification with those new criteria implications for patients' prognosis. STUDY DESIGN AND METHODS: To assess whether NIH consensus (NCC) better predicts survival and response to extracorporeal photochemotherapy (ECP), identify variables associated survival, we retrospectively analyzed 102 patients cGVHD reclassified according NCC treated...