Dietary habits with high consumption of acidic food can induce in orthodontic patients an increased risk demineralization lesions around brackets and bands. The purpose the present laboratory study is to assess vitro visual efficacy a biomimetic nano-hydroxyapatite remineralizing solution hypomineralized enamel surface its effect on adhesion fixed appliances microhardness. Intact teeth were demineralized, subsequently areas visually recorded using 0-100 scale. Subsequently, (Biorepair®...

Autologous graft is considered the gold standard of materials; however, this approach still limited due to both small amount tissue that can be collected and reduced cell viability cells obtained. The aim preliminary study was demonstrate efficacy an innovative medical device called Rigeneracons® (CE certified Class I) provide autologous micro‐grafts immediately available used in clinical practice. Moreover, instrument able create enriched progenitors which maintain their regenerative...

Human population is facing a revolutionary change in the demographic structure with an increasing number of elderly people requiring unmet need to ensure smooth aging process and dental care certainly important aspect that has be considered. To date, dentistry been conservative transferring scientific models regenerative into clinical practice becoming necessity. The aim this study was characterize differentiation commitment (in vitro) grafting ability vivo) progenitor stem cells obtained...

Abstract Study design This single‐masked, randomized and six‐month clinical intervention trial including two study groups was planned to evaluate the efficacy of maintenance treatment with glycine powder on periodontal health peri‐implant tissues. Methods A total 46 patients partial or edentulism, carrying a 88 implants, were assigned either an air abrasive group ( AAD ) manual debridement clorexidine administration MDA ). Clinical data collected before at 3 6 months after treatment. Plaque...

The aim of the study was to compare in a randomized controlled clinical trial use piezoelectric osteotomy as an alternative conventional approach terms surgery time, intraoperative blood loss, cut quality, nerve injury, and costs. One hundred ten patients who had orthognathic procedures with bimaxillary were divided into 2 groups: group A treated piezosurgery device, B, reciprocating saw bur. piezosurgical bone permitted individualized designs. surgical time reduced, mean for mandibular (1...

To evaluate the effect of ceramic firing cycles on interface screw-retained implant-supported metal-ceramic fixed dental prosthesis. Twenty-two frameworks were produced in cobalt-chrome alloy using an integrated CAD/CAM system. The manufactured with additive process milled implantframework interface. total distortion was measured before (T1) and after (T2) thermal cycles. a Coordinate Measuring Machine uncertainty 2.5 nm resolution 25 universal software for dimensional metrology. test...

The histomorphometric results of sinus floor augmentation with deproteinized bovine bone (DBB) and a new fully synthetic substitute, poly(lactic-co-glycolic acid/hydroxyapatite) (PLGA/HA), were compared in humans.Twelve maxillary sinuses eight patients requiring major free concomitant conditions (ASA scores 1 2) studied. Lateral was performed using DBB or PLGA/HA grafts; sites randomly assigned to control test groups. Patients reexamined approximately 6 months after grafting cone beam...

Sinus lift augmentation is a procedure required for the placement of dental implant, whose success can be limited by quantity or quality available bone. To this purpose, first aim current study was to evaluate ability autologous periosteum-derived micrografts and Poly(lactic-co-glycolic acid) (PLGA) supplemented with hydroxyl apatite (HA) induce bone in sinus procedure. Secondly, we compared micrograft's behavior respect biomaterial alone, including Bio-Oss® PLGA/HA, commercially named Alos....

The bone regeneration is one of the most important challenges for regenerative medicine.In maxillo-facial area, resorption alveolar crest occurs after tooth extraction and leads to several risks rehabilitation treatments, including dental implants procedures.Goal our study was demonstrate efficacy an innovative clinical protocol tissue engineering called Rigenera protocol, aimed create optimize bio-complexes constituted by collagen biomaterial human autologous periosteum-derived...

To analyze implant and prosthetic survival rates, complications, patient satisfaction, biological parameters of patients rehabilitated with overdentures (IOV) on splinted nonsplinted implants different attachment systems, in function for one to 17 years.

complex rehabilitations present multiple difficulties, regarding both the planification of surgery and design prothesis. A digital approach can support workflow, as well degree intraoperative precision, improve long-term prognosis. surgical guide was designed for implant placement. An extensive regeneration upper jaw performed with contextual insertion, a delayed load rehabilitation chosen. After four months, second simultaneous soft tissue augmentation performed, 3D-printed temporary...

Abstract Microrough, doubly acid etched titanium surfaces (Ti) were further modified by amination and covalent coupling of fibrillar collagen type I (ColTi). Human Mesenchymal Cells (HMC) adhesion growth, relevant osteogenic differentiation in nonosteogenic (basal) medium evaluated fluorescence microscopy, scanning electron RT‐PCR for a three‐week period. Results show strongly enhanced HMC cell density at short experimental time on ColTi, together with complete spreading the body over...

Although numerous biomaterials are used for maxillary sinus-lift surgery, the ideal material such procedures has not yet been identified. Both heterologous and alloplastic bone substitutes have a solely osteoconductive effect lack osteoinductive properties of morphogenetic proteins typical autologous bone. Our group assessed new graft material, poly(lactic-co-glycolic) acid/hydroxyapatite (PLGA/HA), implanted in human model surgery. For this prospective, random, double-blind trial, we...

Background: Mouthrinses are widely utilized in daily oral and dental hygiene to control plaque. However, most commercially available mouthrinses contain alcohol as an excipient. Most studies have focused on the clinical side effects related alcoholic fraction of mouthrinses, overlooking metabolism mouth. Due this enzymatic process, wellrecognized toxic compound acetaldehyde is emitted Since gingival fibroblasts play a key role connective tissue health maintenance, we investigated different...

Abstract Extracranial-intracranial arterial bypass was performed for intracranial internal carotid artery stenosis in 105 patients who had ischemic symptoms 1 to 3 months before operation. The degree of stenosis, measured angiographically, 60 98%. postoperative patency rate, determined angiographically or by Doppler examination, 97%. surgical mortality rate 1%, and the permanent morbidity 2%. During a mean follow-up period 54 months, 22 died: 10 deaths were caused cardiac disease related...

Abstract The goal of the study was evaluation effect biochemical surface modification by collagen on bone response to acid‐etched titanium surfaces. Fibrillar type I porcine adsorbed and covalently linked Ti disks implants. Adhesion, growth, specific alkaline phosphatase (ALP) activity osteoblast‐like SaOS2 cells were evaluated. Implants in femur tibia rabbit performed for 2 4 weeks relevant implant contact (BIC) evaluated histomorphometry. Results show that cell morphology growth are...

The paper presents results of physico-chemical and biological investigations a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present collagen nanolayer to surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized molecular cues can stimulate progression along osteogenic pathway undifferentiated human mesenchymal cells. Finally, vivo test rabbit model critical defects shows...

Clinical and radiological patterns from 148 patients with post-traumatic subarachnoid haemorrhage (TSAH) were analysed specific regard for the amount distribution of blood in spaces to verify if these variables have any influence on overall outcome. The degree extent TSAH classified according Fisher's criteria: 93 it was grade 1, 36 2, 13 3, six 4. There a significant correlation between increasing clinical severity at admission bleeding direct relation favourable outcome low Fisher grade....

We studied energy metabolism after experimental subarachnoid hemorrhage in rats. Four different cerebral areas were tested: frontal cortex, occipital hippocampus, and brainstem. Vmax of the following enzymatic activities was evaluated: homogenate: hexokinase, phosphofructokinase, lactate dehydrogenase for glycolytic pathway, glucose-6-phosphate hexose monophosphate shunt; purified nonsynaptic mitochondria: NAD+-isocitrate dehydrogenase, citrate synthase, succinate Krebs cycle, cytochrome...