A5069897003- Spine and Intervertebral Disc Pathology
- Intracranial Aneurysms: Treatment and Complications
- Spinal Fractures and Fixation Techniques
- Management of metastatic bone disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Head and Neck Surgical Oncology
- Orthopaedic implants and arthroplasty
- Cerebrovascular and Carotid Artery Diseases
- Medical Imaging and Analysis
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Scoliosis diagnosis and treatment
- Sarcoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Connective tissue disorders research
- Musculoskeletal pain and rehabilitation
- S100 Proteins and Annexins
- Nanoplatforms for cancer theranostics
- Pituitary Gland Disorders and Treatments
- Bone Tissue Engineering Materials
- Spinal Hematomas and Complications
Ospedale di Parma
2019-2024
Ospedale Maggiore
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024
Istituto di Sessuologia Clinica
2020-2024
University of Pavia
1995-2023
Ospedale Humanitas Gradenigo
2021-2023
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
2021-2023
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2022
University of Parma
2019-2021
Istituti Ospitalieri di Cremona
2016-2020
Cytokines are considered as mediators of immune and inflammatory responses. Cisternal CSF levels interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1) the soluble adhesion molecule E-selectin were evaluated in patients operated on for intracranial aneurysms. samples obtained at surgery 41 selected (31 with diagnosis subarachnoid hemorrhage (SAH) 10 control incidental unruptured aneurysms); 14 within 72 h after SAH (early surgery) 17 day (delayed surgery). The cytokines using...
Background: Chronic Subdural Hematoma (CSDH) is a common condition in the elderly population. Recurrence rates after surgical evacuation range from 5 to 30%. Factors predicting recurrence remain debated and unclear. Objective: To identify factors associated with increased risk of recurrence. Methods: Cases CSDHs that underwent treatment between 2005 2018 Neurosurgery Units two major Italian hospitals were reviewed. Data extracted prospectively maintained database included demographics,...
Objective: Intradural Extramedullary (IDEM) tumors are usually treated with surgical excision. The aim of this study was to investigate the impact on clinical outcomes pre-surgical conditions, intraoperative neurophysiological monitoring (IONM), access spinal canal, histology, degree resection and intra/postoperative complications. Methods: This is a retrospective observational analyzing data patients suffering from IDEM who underwent treatment over 12 year period in double-center...
Background: The prognosis of cerebral metastases (MTS) is linked to progression both systemic and local disease. importance MTS resection has been already pointed out. observation a high mortality for not-neurological causes confirms that the modern treatments allow significant control disease within nervous system. Nevertheless, management difficulties increase with multiple lesions in these cases role surgery still be defined.Materials Methods: We collected clinical data patients operated...
In the last few years, treatment of spinal metastases has significantly changed. This is due to advancements in surgical technique, radiotherapy, and chemotherapy which have enriched multidisciplinary management. Above all, field molecular biology tumors continuous prosperous evolution. this review, markers new approaches that radically modified chemotherapeutic strategy most common metastatic neoplasms will be examined together with clinical implications. The experience skills several...
Producing mesenchymal stem cell (MSC)-secretome for dose escalation studies and clinical practice requires scalable good manufacturing (GMP)-compliant production procedures formulation into a standardized medicinal product. Starting from method that combines ultrafiltration freeze-drying to transform MSC-secretome pharmaceutical product, the lyosecretome, this work aims to: (i) optimize lyosecretome formulation; (ii) investigate sources of variability can affect robustness process; (iii)...
Recent studies have suggested that metalloproteinases (MMP) might be involved in the pathogenesis of cerebral aneurysm formation and rupture elevated serum levels MMP may effectively considered as possible markers cerebrovascular malformations. The present study was planned order to verify if MMPs mirror activity wall intracranial aneurysms, reflecting predisposition development and/or rupture. A series 84 patients operated for lesions (63 aneurysms 21 artero-venous malformations ( AVM)) 20...
Background: The effectiveness of antiepileptic prophylaxis in patients with newly diagnosed high-grade glioma is debated. Craniotomy, surgical manipulation and bleeding are believed to favor the onset seizures and, therefore, perioperative drugs (AEDs) generally used. Nevertheless, evidence initiate preoperative AED weak. Aim: Aim this paper was evaluate need for surgically-treated malignant without history seizures. Materials Methods: We conducted a retrospective, two-center cohort study...
The impact of neurological deficits plays a role inestimable importance in patients with neoplastic disease. surgery for the management symptomatic spinal cord compression (SSCC) cannot be overemphasized, as represents often first and paramount step presenting motor deficits. traditional paradigm simple bilateral laminectomy treatment has been reviewed. need to achieve proper circumferential decompression sac progressively highlighted combination development more comprehensive...
Clinical and radiological patterns from 148 patients with post-traumatic subarachnoid haemorrhage (TSAH) were analysed specific regard for the amount distribution of blood in spaces to verify if these variables have any influence on overall outcome. The degree extent TSAH classified according Fisher's criteria: 93 it was grade 1, 36 2, 13 3, six 4. There a significant correlation between increasing clinical severity at admission bleeding direct relation favourable outcome low Fisher grade....
Abstract Spine degenerative conditions are becoming increasingly prevalent, affecting about 5.7% of the population in Europe, resulting a significant reduction life’s quality. Up to now, many materials have been used manufacturing cage implants, as graft substitutes, achieve immediate and long-term spinal fixation. Particularly, titanium its alloys emerging valuable candidates develop new types cages. The aim this vitro study was evaluate adhesion, proliferation osteogenic differentiation...