A5074538393- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Pain Management and Placebo Effect
- Management of metastatic bone disease
- Neurofibromatosis and Schwannoma Cases
- Spine and Intervertebral Disc Pathology
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinoids in leukemia and cellular processes
- Spinal Fractures and Fixation Techniques
- Obsessive-Compulsive Spectrum Disorders
- Nanoparticle-Based Drug Delivery
- Pituitary Gland Disorders and Treatments
- RNA Interference and Gene Delivery
- Neurosurgical Procedures and Complications
- Cancer Research and Treatments
- Vagus Nerve Stimulation Research
- Pain Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- Laser Applications in Dentistry and Medicine
University of Turin
2016-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2018-2024
Agostino Gemelli University Polyclinic
2024
Ospedale Santa Maria
2024
Leonardo (United Kingdom)
2024
University Hospital of Zurich
2024
Fondazione Ricerca Molinette
2021
Neuroscience Institute
2021
Piedmont Reference Center for Epidemiology and Cancer Prevention
2020
Università Campus Bio-Medico
2016
The placebo and nocebo effect is believed to be mediated by both cognitive conditioning mechanisms, although little known about their role in different circumstances. In this study, we first analyzed the effects of opposing verbal suggestions on experimental ischemic arm pain healthy volunteers motor performance Parkinsonian patients found that verbally induced expectations analgesia/hyperalgesia improvement/worsening antagonized completely a procedure. We also measured hormonal secretion...
Objectives: Bilateral chronic high frequency stimulation of the subthalamic nucleus (STN), through stereotactical placement stimulating electrodes, effectively improves motor symptoms severe Parkinson9s disease. Intraoperative neurophysiological and clinical monitoring techniques (neuronal electrical activity recording intraoperative stimulation) may improve refine localisation nucleus. The objective this work was to compare preoperative CT MRI with identification STN. relation between STN...
Any medical treatment has 2 components, the first being specific effects of itself, second, knowledge that is performed (the placebo effect). So far, effect been studied by eliminating therapy through administration a dummy treatment. In this study, authors reversed experimental approach. fact, whereas were maintained constant, patient's was done away with. To do this, hidden treatments and compared these with open ones. The results show administrations pharmacological nonpharmacological...
Abstract Deep brain stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease. The benefits bilateral are well documented, and some studies reported outcomes with a follow‐up 5 to 6 years; nevertheless, few data available beyond years. We report long‐term prospective evaluation 14 consecutive parkinsonian patients, treated by at least 9 Motor symptoms, activity daily living, motor complications were evaluated means Unified Disease Rating Scale, while...
<i>Objective:</i> To evaluate modifications occurring in cognitive functions and behavioural aspects a group of 72 consecutive patients with Parkinson’s disease (PD) 15 months after bilateral deep brain stimulation (DBS) the subthalamic nucleus (STN). <i>Methods:</i> PD bilaterally implanted for DBS STN were evaluated before surgery mean follow-up months. A neuropsychological assessment was performed to reasoning (Raven Colour Matrices), memory (Bisyllabic Word...
Clinical findings in Parkinson's disease suggest that most patients progressively develop disabling non-levodopa-responsive symptoms during the course of disease. Nevertheless, several heterogeneous factors, such as clinical phenotype, age at onset and genetic aspects may influence long-term picture. In order to investigate main features progression, we studied a cohort 19 subjects treated with subthalamic nucleus deep brain stimulation after >20 years disease, reporting neuropsychological...
Thalamic deep brain stimulation is a mainstay treatment for severe and drug-refractory essential tremor, but postoperative management may be complicated in some patients by progressive cerebellar syndrome including gait ataxia, dysmetria, worsening of intention tremor dysarthria. Typically, this manifests several months after an initially effective therapy necessitates frequent adjustments parameters. There ongoing debate as to whether ataxia reflects delayed therapeutic failure due disease...
Expectations about future events are known to trigger neural mechanisms that affect both perception and action. Here we report different opposite expectations of bad good motor performance modulate the therapeutic effects subthalamic nucleus stimulation in Parkinsonian patients who had undergone chronic implantation electrodes for deep brain stimulation. By analyzing on velocity movement right hand, found hand be faster when expected a performance. The expectation was induced through...
The authors report the data relative to clinical effectiveness of bilateral deep brain stimulation subthalamic nucleus in 16 patients with PD 3 months after surgery. comparison Unified Rating Scale scores different conditions medication and stimulation, lack significant surgical complications, confirm safety for treatment advanced PD.
<i>Objective:</i> To evaluate motor and nonmotor symptoms in patients with Parkinson’s disease undergoing bilateral deep brain stimulation of the subthalamic nucleus (STN DBS). <i>Methods:</i> Thirty-six consecutive receiving STN implants were evaluated preoperatively as well 12 24 months after surgery. Motor assessed through Unified Disease Rating Scale (UPDRS). Data concerning collected from items UPDRS 2 additional questions clinical charts regarding constipation...
Key points We analysed the placebo response at single‐neuron level in thalamus of Parkinson patients to see differences between first‐time administration and after pharmacological pre‐conditioning. When was given for first time, it induced neither clinical improvement, as assessed through muscle rigidity reduction wrist, nor neuronal changes thalamic neurons. However, if two, three or four prior administrations an anti‐Parkinson drug, apomorphine, produced both responses. Both magnitude...
Background: Chronic Subdural Hematoma (CSDH) is a common condition in the elderly population. Recurrence rates after surgical evacuation range from 5 to 30%. Factors predicting recurrence remain debated and unclear. Objective: To identify factors associated with increased risk of recurrence. Methods: Cases CSDHs that underwent treatment between 2005 2018 Neurosurgery Units two major Italian hospitals were reviewed. Data extracted prospectively maintained database included demographics,...
Glioblastoma is the most common and invasive primary tumor of central nervous system normally has a negative prognosis. Biodistribution in healthy animal models an important preliminary study aimed at investigating efficacy chemotherapy, as it mainly addressed towards residual cells after surgery region with intact blood–brain barrier. Nanoparticles have emerged versatile vectors that can overcome In this experimental work, solid lipid nanoparticles, prepared using fatty acid coacervation,...
Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson's disease, dystonia, and essential tremor, has shown clinical benefits in other disorders. A natural path improvement this technique to continuously observe effects on patient symptoms neurophysiological markers. This requires evolution conventional deep stimulators bidirectional interfaces, able record, process, store, wirelessly communicate neural signals a robust reliable fashion. Here, we...
In the recent years, growing interest in simulation-based surgical education has led to various practical alternatives for medical training. More recently, courses based on virtual reality (VR) and three-dimensional (3D)-printed models are available. this paper, a hybrid (virtual physical) neurosurgical simulator been validated, equipped with augmented (AR) capabilities that can be used repeatedly increase familiarity improve technical skills human brain anatomy approaches.The study...