A5083325160- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Hypoxia, and Metabolism
- Spine and Intervertebral Disc Pathology
- Vascular Malformations Diagnosis and Treatment
- Brain Metastases and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging Techniques and Applications
- MicroRNA in disease regulation
- RNA Research and Splicing
- Anatomy and Medical Technology
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Medical Imaging and Analysis
- Cancer Treatment and Pharmacology
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Lymphoma Diagnosis and Treatment
University of Campania "Luigi Vanvitelli"
2024-2025
Ospedale San Carlo
2024
University of Turin
2014-2023
University of Catania
2019-2023
Policlinico Universitario di Catania
2019-2023
Neurological Surgery
2020-2021
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2018-2020
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2020
Piedmont Reference Center for Epidemiology and Cancer Prevention
2019
Fondazione Ricerca Molinette
2017
Glioblastoma multiforme (GBM) is the most frequent and deadly human brain cancer. Early diagnosis through non-invasive biomarkers may render GBM more easily treatable, improving prognosis of this currently incurable disease. We suggest use serum extracellular vesicle (sEV)-derived circular RNAs (circRNAs) as highly stable minimally invasive diagnostic for diagnosis. EVs were isolated by size exclusion chromatography from sera 23 5 grade 3 glioma (GIII) patients, 10 unaffected controls (UC)....
Abstract Background Extent of tumor resection (EOTR) in glioblastoma surgery plays an important role improving survival. Objective To analyze the efficacy, safety and reliability fluid-attenuated inversion-recovery (FLAIR) magnetic resonance (MR) images used to guide ( FLAIRectomy ) volumetrically measure postoperative EOTR, which was correlated with clinical outcome Methods A total 68 patients (29 males, mean age 65.8) were prospectively enrolled. Hyperintense areas on FLAIR images,...
Lactic acidosis has been reported in solid tumor microenvironment (TME) including glioblastoma (GBM). In TME, several signaling molecules, growth factors and metabolites have identified to induce resistance chemotherapy sustain immune escape. the early phases of disease, microglia infiltrates contributing tumorigenesis rather than counteracting its growth. Insulin-like Growth Factor Binding Protein 6 (IGFBP6) is expressed during development, it involved migration, immune-escape inflammation,...
Circular RNAs (circRNAs) are a large class of with regulatory functions within cells. We recently showed that circSMARCA5 is tumor suppressor in glioblastoma multiforme (GBM) and acts as decoy for Serine Arginine Rich Splicing Factor 1 (SRSF1) through six predicted binding sites (BSs). Here we characterized RNA motifs functionally involved the interaction between SRSF1. Three different molecules (Mut1, Mut2, Mut3), each mutated two SRSF1 BSs at once, were obtained PCR-based replacement...
Radiomics holds great promise in the field of cancer management. However, clinical application radiomics has been hampered by uncertainty about robustness features extracted from images. Previous studies have reported that are sensitive to changes voxel size resampling and interpolation, image perturbation, or slice thickness. This study aims observe variability positron emission tomography (PET) under impact co-registration with magnetic resonance imaging (MRI) using difference percentage...
The tumor microenvironment (TME) plays a pivotal role in establishing malignancy, and it is associated with high glycolytic metabolism lactate release through monocarboxylate transporters (MCTs). Several lines of evidence suggest that also serves as signaling molecule its receptor hydroxycarboxylic acid 1 (HCAR1/GPR81), thus functioning paracrine autocrine molecule. aim the present study was to investigate glioblastoma (GBM) progression metabolic reprogramming an
Background/Objectives: Degenerative lumbar spine conditions are a major cause of disability, particularly in elderly patients or those with comorbidities. Surgical treatment often combines decompression and stabilization to address pain instability. Pedicle screws the gold standard for but pose challenges compromised bone quality. Interspinous devices have emerged as less invasive alternative, comparative studies limited. This study aimed compare clinical surgical outcomes using pedicle...
Background/Objectives: Lumbar disk herniation (LDH) significantly affects quality of life due to lower back and radiating leg pain. Surgical intervention, such as discectomy, is effective for symptom relief when conservative measures fail; however, psychological factors like anxiety, depression, maladaptive coping strategies may negatively impact surgical outcomes. This study aims assess the role preoperative evaluations in predicting postoperative recovery identify key functional predictors...
Background: The aim of this study was to investigate the immunohistochemical expression and distribution serine arginine rich splicing factor 1 (SRSF1) in a series 102 cases both diffuse circumscribed adult gliomas establish potential diagnostic role protein differential diagnosis brain tumors. Methods: This retrospective included 42 glioblastoma cases, 21 oligodendrogliomas, 15 ependymomas, pilocytic astrocytomas, 5 sub-ependymal giant cell astrocytoma 4 pleomorphic xanthoastrocytomas....
The management of patients with Central Nervous System (CNS) malignancies relies on the appropriate classification these tumors. Recently, World Health Organization (WHO) has published new criteria underlining importance an accurate molecular characterization CNS malignancies, in order to integrate information generated by histology. Next generation sequencing (NGS) allows single step multiple genes, generating a comprehensive and specific mutational profile tumor tissue. We developed custom...
Nowadays, Machine Learning (ML) algorithms have demonstrated remarkable progress in image-recognition tasks and could be useful for the new concept of precision medicine order to help physicians choice therapeutic strategies brain tumours. Previous data suggest that, central nervous system (CNS) tumours, amino acid PET may more accurately demarcate active disease than paramagnetic enhanced MRI, which is currently standard method evaluation tumours helps assessment grading, as a fundamental...
OBJECTIVE No consensus exists on the best treatment for recurrent high-grade glioma (HGG), particularly in terms of surgical indications, and scant data are available integrated use multiple technologies to overcome intraoperative limits pitfalls related artifacts secondary previous surgery radiotherapy. Here, authors report their experience with integration tools HGG surgery, analyzing pros cons as well effectiveness increasing extent tumor resection. In addition, they present a review...
The extent of resection beyond the enhancing core (EC) in glioblastoma IDH-wild type (GBM, IDHwt) is one most debated topics neuro-oncology. Indeed, it has been demonstrated that local disease recurrence often arises peritumoral areas and radiologically-defined FLAIR hyperintensity GBM IDHwt are visible conventional EC. Therefore, need to extend surgical also a matter debate. Since little known about histological composition regions, this study we aimed provide comprehensive description...