A5024770382- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Brain Metastases and Treatment
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Spine and Intervertebral Disc Pathology
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Fractures and Fixation Techniques
- Vascular Malformations Diagnosis and Treatment
- Anesthesia and Pain Management
- Pituitary Gland Disorders and Treatments
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Cell Adhesion Molecules Research
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Traumatic Brain Injury Research
- Fetal and Pediatric Neurological Disorders
- Long-Term Effects of COVID-19
- Lung Cancer Research Studies
- Diet and metabolism studies
Policlinico Umberto I
2020-2025
Sapienza University of Rome
1994-2025
Cornell University
2024
Neurological Surgery
2024
Azienda Ospedaliera Sant'Andrea
2017-2019
Background: Chronic Subdural Hematoma (CSDH) is a common condition in the elderly population. Recurrence rates after surgical evacuation range from 5 to 30%. Factors predicting recurrence remain debated and unclear. Objective: To identify factors associated with increased risk of recurrence. Methods: Cases CSDHs that underwent treatment between 2005 2018 Neurosurgery Units two major Italian hospitals were reviewed. Data extracted prospectively maintained database included demographics,...
Background: The genitofemoral nerve is the most variable of lumbar plexus, in terms its course and bifurcation, thus it must be taken into consideration during extended pelvic lymph node dissection. Its borders, robotic, laparoscopic or open radical prostatectomy for intermediate high-grade prostate cancer, have long been defined usually respected; represents lymph-node dissection lateral boundary may vary from case to putting integrity at risk. Materials methods: For first time, here...
With the increasing life expectancy, a large number of intracranial meningiomas (IM) have been identified in elderly patients. There is no general consensus regarding management for IMs nor studies outcome older patients undergoing meningioma surgery. We aimed to determine whether preoperative variables and postoperative clinical outcomes differ between age groups after analyzed data from all who had undergone IM surgery our departments. The final cohort consisted 340 affected by with ASA...
In the latest 2021 WHO classification of central nervous system tumours (CNS), gliomas that present isocitrate dehydrogenase (IDH) mutations are defined as diffuse low-grade (DLGGs). IDH commonly observed in this tumour type. The Extent Resection (EOR) positively influence survival; however, it is still debated whether predictive value EOR independent 1p/19q co-deletion. We carried out a retrospective analysis on patients operated for DLGG at Sant'Andrea University Hospital Sapienza Rome,...
Normal Pressure Hydrocephalus (iNPH) typically affects the elderly and can cause cognitive decline, resulting in its differential diagnosis with other neurodegenerative conditions. Moreover, it is probably underdiagnosed; such under- misdiagnosis prevents patient from receiving right treatment significantly quality of life expectancy. This investigation an in-depth analysis actual incidence iNPH population province served by our hospital (circa 580,000 individuals). The first phase this...
Background: Brain metastases (BMs) is one of the most frequent metastatic sites for non-small-cell lung cancer (NSCLC). It a matter debate whether EGFR mutation in primary tumor may be marker disease course, prognosis, and diagnostic imaging BMs, comparable to that described brain tumors, such as glioblastoma (GB). This issue was investigated present research manuscript. Methods: We performed retrospective study identify relevance mutations prognostic factors imaging, survival, course within...
Giant intracranial meningiomas (GIMs) are a subgroup of with huge dimensions maximum diameter more than 5 cm. The mechanisms by which meningioma can grow to be defined as “giant” unknown, and the biological, radiological profile different outcomes poorly investigated. We performed multi-centric retrospective study series surgically treated patients suffering from meningioma. All were assigned on grounds preoperative imaging giant medium/large groups cut-off investigated whether presence...
High-Grade Gliomas are the most common primary brain malignancies and despite multimodal treatment, increasing amount of adjuvant treatment options overall prognosis remains dismal. The present investigation aims to analyze safety profile use intraoperative ultrasounds (Io-US) in a homogeneous matched cohort patients suffering from High-grade gliomas (HGG) operated on with or without aid Io-US Fluorescein specific relation incidence neurological functional status sequelae.
Background: Glioblastoma (GBM) contacting the Subventricular Zone (SVZ) may display a more aggressive pattern of invasiveness with higher potential to recruit migratory progenitor cells.We aims determine relationships between location lesion and clinical, molecular characteristics outcome in patients affected by GBM.Methods: The surgical, radiological clinical outcomes have been retrospectively reviewed for present study.All classified according their anatomical relationship SVZ + SVZ-.A...
Maximal surgical resection remains the treatment of choice for grade II meningiomas, and some authors it is sufficient to guarantee a long indolent course even without postsurgical radiotherapy (RT), but there no consensus on use RT in this patient population. We retrospectively compared clinical radiologic outcomes between World Health Organization I (group A) B) surgically treated focusing role adjuvant RT. registered clinical, surgical, data detect differences survival functional outcome...
Glioblastoma (GBM) is the most common and aggressive primary brain neoplasia in adults. Seizure a manifestation GBM. Up to 25 60% of patients with GBM have seizures. We aim summarize all relevant clinical, surgical, radiologic, molecular features cohort suffering from GBM-related epilepsy measure outcome, understand possible existence clinical/phenotypical specificity this subgroup patients. retrospectively analyzed 177 affected by isocitrate dehydrogenase wild-type (IDH-WT) GBM; 49...
Glioblastoma is an aggressive brain tumor with average life expectancy between 14 and 16 months after diagnosis. The Ki-67 labeling index (LI), a measure of cellular proliferation, emerging as prognostic marker in GBM. In this study, we investigated the ultrastructure glioblastoma tissue from 9 patients same molecular profile (adult IDH wild-type glioblastoma, ATRX, positive for TP53 expression, GFAP EGFR overexpression) to find possible ultrastructural features be used biomarkers correlated...