A5012943847- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Spine and Intervertebral Disc Pathology
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- Brain Metastases and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Management of metastatic bone disease
- Neurosurgical Procedures and Complications
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Sarcoma Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Medical Imaging and Analysis
- Medical Imaging Techniques and Applications
- Pelvic and Acetabular Injuries
Istituto Neurologico Mediterraneo
2022-2025
Policlinico Umberto I
2018-2025
University of Turin
2024
Sapienza University of Rome
2016-2024
Neurological Surgery
2022
Weill Cornell Medicine
2022
Cornell University
2022
Ospedale Santa Maria Goretti
2021
Azienda Ospedaliera Sant'Andrea
2018
Glioblastoma is a highly aggressive and invasive tumor that affects the central nervous system (CNS). With five-year survival rate of only 6.9% median time eight months, it has lowest among CNS tumors. Its treatment consists surgical resection, subsequent fractionated radiotherapy concomitant adjuvant chemotherapy with temozolomide. Despite implementation clinical interventions, recurrence common occurrence, over 80% cases arising at edge resection cavity few months after treatment. The high...
Neurosurgical indications for the superior eyelid transorbital endoscopic approach (SETOA) are rapidly expanding over last years. Nevertheless, as any new technique, a detailed knowledge of anatomy surgical target area, operative corridor, and specific landmark from this different perspective is required safest successful surgery. Therefore, aim study to provide, through anatomical dissections, investigation revealed by SETOA via anterolateral triangle middle cranial fossa. We also sought...
Background: The cavernous sinus (CS) is a highly vulnerable anatomical space, mainly due to the neurovascular structures that it contains; therefore, detailed knowledge of its anatomy mandatory for surgical unlocking. In this study, we compared region from different endoscopic and microsurgical operative corridors, further focusing on corresponding anatomic landmarks encountered along these routes. Furthermore, tried define safe entry zones venous space three provide indications regarding...
Gliomas within the insular region represent one of most challenging problems in neurosurgical oncology. There are two main surgical approaches to address complex vascular network and functional areas around insula: transsylvian approach transcortical approach. In literature, there is not a clear consensus on best terms safety efficacy. The purpose this study evaluate effectiveness these analyze prognostic factors natural history gliomas. Patients with newly diagnosed high-grade gliomas who...
Objectives The World Health Organization (WHO) grade I intracranial meningiomas (IMs) maintain a certain risk of recurrence (~10%) even if gross total resection is achieved. Most studies analyzing predictive factors benign meningioma focus on histological changes and related to radiologic-therapeutic follow-up. Few authors have speculated the role meningioma-related epilepsy developing recurrence. presence seizures their onset remained relatively understudied date in patients. Materials...
Chronic Subdural Hematoma (CSDH) is one of the most frequently encountered conditions in neurosurgical practice. The role timing CSDH surgery mild symptomatic patients remains uncertain. aim this study was to analyze prognostic surgical with CSDH. In multicenter retrospective study, diagnosed who underwent evacuation were enrolled. Marwalder Grading System (MGS) and GCS scores used for neurological evaluation. Patients presenting preoperative score ≥ 13 MGS ≤ 2 defined as "mild symptomatic"....
Background: Glioblastomas (GBM) are generally burdened, to date, by a dismal prognosis, although long term survivors have relatively significant incidence. Our specific aim was determine the exact impact of many surgery-, patient- and tumor-related variables on survival parameters. Methods: The surgical, radiological clinical outcomes patients been retrospectively reviewed for present study. All operated in our institution classified according their overall (LTS) short (STS). A thorough...
With the increasing life expectancy, a large number of intracranial meningiomas (IM) have been identified in elderly patients. There is no general consensus regarding management for IMs nor studies outcome older patients undergoing meningioma surgery. We aimed to determine whether preoperative variables and postoperative clinical outcomes differ between age groups after analyzed data from all who had undergone IM surgery our departments. The final cohort consisted 340 affected by with ASA...
Peritumoral brain edema (PBE) is common in intracranial meningiomas (IM) and can increase their morbidity. It not uncommon for a neurosurgeon to confront with large proportion of PBE independently from the site size contrast-enhancing lesion increased surgical risks. We performed retrospective review 216 surgically-treated patients suffering IM. recorded clinical, biological, radiological data based on rate tumor volume divided into group high Edema/Tumor ratio low ratio. investigated how...
The goal of glioma surgery is maximal tumor resection associated with minimal post-operative morbidity. Diffusion tensor imaging-tractography/fiber tracking (DTI-FT) a valuable white-matter (WM) visualization tool for diagnosis and surgical planning. Still, it assumes descriptive role since the main DTI metrics parameters showed several limitations in clinical use. New applications quantitative measurements were recently applied to describe WM architecture that surround area. brain adjacent...
Background: Brain metastases (BMs) is one of the most frequent metastatic sites for non-small-cell lung cancer (NSCLC). It a matter debate whether EGFR mutation in primary tumor may be marker disease course, prognosis, and diagnostic imaging BMs, comparable to that described brain tumors, such as glioblastoma (GB). This issue was investigated present research manuscript. Methods: We performed retrospective study identify relevance mutations prognostic factors imaging, survival, course within...