A5035816396- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Essential Oils and Antimicrobial Activity
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Bee Products Chemical Analysis
- CAR-T cell therapy research
- Curcumin's Biomedical Applications
- Corneal Surgery and Treatments
- Synthesis and biological activity
- TiO2 Photocatalysis and Solar Cells
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmacological Effects and Toxicity Studies
- Graphene and Nanomaterials Applications
- Vascular Malformations Diagnosis and Treatment
- Boron Compounds in Chemistry
- Long-Term Effects of COVID-19
- Cancer Research and Treatments
- Magnetic and Electromagnetic Effects
- Virus-based gene therapy research
University of Turin
2016-2025
PRG S&Tech (South Korea)
2014
The traits of lipid biocompatibility and versatility have led to many nano- microparticulate formulations being engineered, over the last two decades, in form spheres capsules, using solid liquid lipids as matrices. This review describes main types microparticles, well their preparation methods, administration routes, fields application. It will also provide a synthetic overview patents that been filed. Patenting activity nanoparticle field has ongoing for 25 years driven by boom use...
Solid lipid nanoparticles (SLN) of fatty acids (FAs) were prepared with a new, solvent-free technique based on FAs precipitation from their sodium salt micelles in the presence polymeric non-ionic surfactants: this was called ‘coacervation’. Myristic, palmitic, stearic, arachidic and behenic acid employed as matrixes. Spherical shaped mean diameters ranging 250 to ∼500 nm obtained. Different aqueous acidifying solutions used precipitate various micellar solution. Good encapsulation...
A method to produce solid lipid nanoparticles (SLN) from W/O/W multiple emulsions was developed applying the solvent-in-water emulsion-diffusion technique. Insulin chosen as hydrophilic peptide drug be dissolved in acidic inner aqueous phase of and consequently carried SLN. Several partially water-miscible solvents with low toxicity were screened order optimize SLN composition, after assessing that insulin did not undergo any chemical modification presence different under production process...
Curcumin (CU) loaded solid lipid nanoparticles (SLNs) of fatty acids (FA) were prepared with a coacervation technique based on FA precipitation from their sodium salt micelles in the presence polymeric non-ionic surfactants. Myristic, palmitic, stearic, and behenic acids, different polymers various molecular weights hydrolysis grades employed as matrixes stabilisers, respectively. Generally, spherical-shaped mean diameters below 500 nm obtained, using only middle-high hydrolysis,...
Glioblastoma, the most common primary brain tumor in adults, has an inauspicious prognosis, given that overcoming blood-brain barrier is major obstacle to pharmacological treatment of tumors. As neoangiogenesis plays a key role glioblastoma growth, US Food and Drug Administration approved bevacizumab (BVZ), antivascular endothelial growth factor antibody for recurrent patients whose initial therapy failed. In this experimental work, BVZ was entrapped solid lipid nanoparticles (SLNs) prepared...
Aim: To develop an innovative delivery system for temozolomide (TMZ) in solid lipid nanoparticles (SLN), which has been preliminarily investigated the treatment of melanoma. Materials and Methods: SLN-TMZ was obtained through fatty acid coacervation. Its pharmacological effects were assessed compared with free TMZ vitro vivo models melanoma glioblastoma. Results: Compared to standard TMZ, exerted larger effects, when cell proliferation cells, neoangiogeneis evaluated. also inhibited growth...
Solid lipid nanoparticles (SLNs) comprise a versatile drug delivery system that has been developed for the treatment of variety diseases. The present study will investigate feasibility entrapping an active doxorubicin prodrug (a squalenoyl-derivative) in SLNs. derivative-loaded SLNs are spherically shaped, have mean diameter 300–400 nm and show 85% w/w entrapment efficiency. effects on cell growth loaded SLNs, free examined using cytotoxicity colony-forming assays both human ovarian cancer...
Glioblastoma is the most common and invasive primary tumor of central nervous system normally has a negative prognosis. Biodistribution in healthy animal models an important preliminary study aimed at investigating efficacy chemotherapy, as it mainly addressed towards residual cells after surgery region with intact blood–brain barrier. Nanoparticles have emerged versatile vectors that can overcome In this experimental work, solid lipid nanoparticles, prepared using fatty acid coacervation,...
Insulin-loaded solid lipid nanoparticles (SLN), obtained by the solvent-in-water emulsion–diffusion technique, were produced using isovaleric acid (IVA) as organic phase, glyceryl mono-stearate (GMS) lipid, soy lecithin and sodium taurodeoxycholate (TDC) emulsifiers. IVA, a partially water-miscible solvent with low toxicity, was used to dissolve both insulin lipids. SLN of spherical shape simple water dilution O/W emulsion. Analysis content after processing showed interesting encapsulation...
Aims: Advanced melanoma is characterized by poor outcome. Despite the number of treatments having been increased over last decade, current pharmacological strategies are only partially effective. Therefore, improvement systemic therapy worthy investigation. Methods: a nanotechnology-based poly-chemotherapy was tested at preclinical level. Temozolomide, rapamycin, and bevacizumab were co-loaded as injectable nanoemulsions for total parenteral nutrition (Intralipid®), due to suitable devices,...
Stearic acid solid lipid nanoparticles were prepared according to a new technique, called coacervation. The main goal of this experimental work was the entrapment peptide drugs into SLN, which is difficult task, since their chemical characteristics (molecular weight, hydrophilicity, and stability) hamper peptide‐containing formulations. Insulin leuprolide, chosen as model drugs, encapsulated within after hydrophobic ion pairing with anionic surfactants. Peptide integrity maintained...