A5021255644- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Dermatology and Skin Diseases
- Systemic Lupus Erythematosus Research
- Surfactants and Colloidal Systems
- Nanoplatforms for cancer theranostics
- Free Radicals and Antioxidants
- Microfluidic and Capillary Electrophoresis Applications
- Glioma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Antioxidant Activity and Oxidative Stress
- Bee Products Chemical Analysis
- Retinal Development and Disorders
- Essential Oils and Antimicrobial Activity
- Corneal Surgery and Treatments
- Cancer Research and Treatments
- Pickering emulsions and particle stabilization
- Biochemical effects in animals
- Phytochemicals and Antioxidant Activities
University of Turin
2016-2025
PRG S&Tech (South Korea)
2014
Multidrug resistance (MDR) is a critical hindrance to the success of cancer chemotherapy. The main thing responsible for MDR phenotypes are plasma-membranes associated with adenosine triphosphate (ATP) Binding Cassette (ABC) drug efflux transporters, such as P-glycoprotein (Pgp) transporter that has broadest spectrum substrates. Curcumin (CURC) Pgp inhibitor, but it poorly soluble and bioavailable. To overcome these limitations, we validated efficacy safety CURC, loaded in biocompatible...
A method to produce solid lipid nanoparticles (SLN) from W/O/W multiple emulsions was developed applying the solvent-in-water emulsion-diffusion technique. Insulin chosen as hydrophilic peptide drug be dissolved in acidic inner aqueous phase of and consequently carried SLN. Several partially water-miscible solvents with low toxicity were screened order optimize SLN composition, after assessing that insulin did not undergo any chemical modification presence different under production process...
Curcumin (CU) loaded solid lipid nanoparticles (SLNs) of fatty acids (FA) were prepared with a coacervation technique based on FA precipitation from their sodium salt micelles in the presence polymeric non-ionic surfactants. Myristic, palmitic, stearic, and behenic acids, different polymers various molecular weights hydrolysis grades employed as matrixes stabilisers, respectively. Generally, spherical-shaped mean diameters below 500 nm obtained, using only middle-high hydrolysis,...
Glioblastoma, the most common primary brain tumor in adults, has an inauspicious prognosis, given that overcoming blood-brain barrier is major obstacle to pharmacological treatment of tumors. As neoangiogenesis plays a key role glioblastoma growth, US Food and Drug Administration approved bevacizumab (BVZ), antivascular endothelial growth factor antibody for recurrent patients whose initial therapy failed. In this experimental work, BVZ was entrapped solid lipid nanoparticles (SLNs) prepared...
Background: Solid lipid nanoparticles (SLNs) are attractive drug delivery systems for lipophilic molecules like curcumin (CURC) with low chemical stability. Methods: A simple, innovative, and cold-operating method, named "cold dilution of microemulsion" is developed by the authors to produce SLNs. An oil-in-water microemulsion (µE), whose disperse phase consisted a solution trilaurin in partially water-miscible solvent, was prepared after mutually saturating solvent water. Trilaurin SLNs...
Therapeutic resistance in glioblastoma multiforme (GBM) has been linked to a subpopulation of cells with stem cell-like properties, the glioma (GSCs), responsible for cancer progression and recurrence. This study investigated vitro cytotoxicity three chemotherapeutics, temozolomide (TMZ), doxorubicin (Dox) paclitaxel (PTX) on cell lines, by analyzing molecular mechanisms leading DNA repair resistance, or death. The drugs were tested 16 GBM grown as neurospheres (NS) adherent (AC), studying...
Aim: Methotrexate-loaded biocompatible nanoparticles were tested for preliminary efficacy in glioma treatment. Materials & methods: Behenic acid nanoparticles, prepared by the coacervation method, loaded with ester prodrug didodecylmethotrexate, which was previously vitro against glioblastoma human primary cultures. Nanoparticle conjugation an ApoE mimicking chimera peptide performed to obtain active targeting brain. Results conclusion: Biodistribution studies healthy rats assessed...
Chitosan is an excipient which has been studied thoroughly in research works thanks to its positive characteristics such as muco-adhesiveness and ability open epithelial-tight-junctions. In this article, lipophilic stearoyl chitosan (ST-CS) was synthetized order anchor polymer lipid nanoparticles prepare ST-CS-coated (ST-CS-NP) using the microemulsion cold dilution technique. Curcumin (CURC) used model drug. CURC-ST-CS-NP were characterized by dimensional analysis, zeta potential, drug...
Endophthalmitis is a rare, but serious, intravitreal inflammatory disorder that can arise after cataract surgery. The intracameral injection of 1 mg cefuroxime (CEF) followed by three-times daily antibiotic topical administration for week generally recognized as the routine method prophylaxis This procedure controversial because both low efficacy and adherence to therapy elderly patients. A unique slow release could solve these problems. objective present study was design ophthalmic...
Doxorubicin (DOXO) lauroyl ester and amide were proposed as lipophilic derivatives entrapped in SLNs. DOXO derivatives-loaded SLNs spherical shaped, had 200-300 nm mean diameters showed 80-94% w/w drug entrapment efficiencies. The effect of free on cell growth was examined by MTT colony-forming assays four different tumour lines: a pancreatic, CFPAC-1, lung, A549, two ovarian, A2780 A2780res (DOXO-resistant). results obtained with assay show that although displayed an inhibition...
In this study, an overview of the regulations in force some extra-EU states belonging to different geoeconomic areas is provided, starting from current EU legislation on cosmetic products. We focused their legislative frameworks and location relevant regulatory documentation. Furthermore, for each state considered, our analysis examined notification/authorization processes, approaches animal testing, allowed/prohibited ingredient lists, as these aspects are considered be among primary...