A5086490466- Drug-Induced Hepatotoxicity and Protection
- Echinoderm biology and ecology
- Seaweed-derived Bioactive Compounds
- Nanoparticles: synthesis and applications
- Bone Metabolism and Diseases
- Animal testing and alternatives
- Natural Antidiabetic Agents Studies
- Moringa oleifera research and applications
- Environmental Toxicology and Ecotoxicology
- Bioactive Compounds and Antitumor Agents
- Parasites and Host Interactions
- Essential Oils and Antimicrobial Activity
- Parasite Biology and Host Interactions
- Medicinal Plants and Neuroprotection
- Drug Transport and Resistance Mechanisms
- Kidney Stones and Urolithiasis Treatments
- Antifungal resistance and susceptibility
- Vitamin K Research Studies
- Coccidia and coccidiosis research
- Marine Sponges and Natural Products
- Bone health and osteoporosis research
- Helminth infection and control
- Bone health and treatments
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects of Natural Compounds
Cairo University
2016-2025
Al-Azhar University
2019-2025
Institute of Zoology
2021
Symbiosis International University
2018
Symbiosis Group
2018
Multidrug resistance (MDR) is a critical hindrance to the success of cancer chemotherapy. The main thing responsible for MDR phenotypes are plasma-membranes associated with adenosine triphosphate (ATP) Binding Cassette (ABC) drug efflux transporters, such as P-glycoprotein (Pgp) transporter that has broadest spectrum substrates. Curcumin (CURC) Pgp inhibitor, but it poorly soluble and bioavailable. To overcome these limitations, we validated efficacy safety CURC, loaded in biocompatible...
Rodents are widely used for animal research in Egypt. Pentobarbital is the most common anesthetic agent; however overdoses may affect experimental outcomes and limit use of tissues. To investigate effects sodium pentobarbital during exsanguination, three groups (6 rats/group) male female rats were injected i.p. with 50, 100 150 mg/kg pentobarbital, then carotid exsanguination was performed immediately after loss consciousness. Hypoxia-inducible factor 1-alpha (Hif1a) tumor necrosis...
Oxidative stress is a common mechanism contributing to the initiation and progression of hepatic damage. Hence there great demand for development agents with potent antioxidant effect. The aim present study evaluate efficacy Holothuria atra extract (HaE) as an against 7,12-dimethylbenz[a]anthracene- (DMBA-) induced hepatorenal dysfunction. Experimental animals were divided into two main groups: protective curative. Each group was then five subgroups pre- or posttreated either distilled water...
Although animal research ethics committees (AREC) are well established in Western countries, this field is weakly developed and its concept poorly understood the Middle East North Africa region.Our main objective was to introduce requirements of ethical approaches dealing with experimental teaching Egypt.Due very recent inception, Cairo University, Faculty Science IACUC decided operate accordance Guide for Care Use Laboratory Animals 8th Edition 2011 (the Guide) since Egypt has not yet...
Background: Sepsis is a severe medical disorder that poses significant risk to life, leading elevated rates of sickness and mortality globally, reaching 11 million annually. It distinguished by an imbalanced immune response infection, which subsequently causes failure in several organs. Eugenol obtained from clove oil possesses various beneficial properties, such as antifungal, anti-inflammatory, antiviral, antioxidant, anticancer, antibacterial effects. Aim: The present study aimed assess...
Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition affecting cognitive and social functions all over childhood. Monosodium glutamate (MSG) common food additive associated with ADHD-like symptoms in children. Nutraceuticals, like sesamol (SE) astaxanthin (AST), or physical activity (PHA) were reported to possess beneficial effects on human health. Meanwhile, still their neuroprotective effect against ADHD has been poorly investigated. This study aimed...
The present study aims to evaluate the possible protective role of polysaccharides extracted from Egyptian mango Mangifera indica L. (MPS) and silymarin against cyclophosphamide (CP) nephrotoxicity in male albino rats. Male rats were randomly divided into, control group (administered distilled water orally for 10 days) MPS (500, 1000 mg/kg, p.o.) and/or (150 treated groups days. In last 5 days treatment administered CP i.p). revealed significant prophylactic effect kidney injury induced by...
Holothuria arenicola is the most important and abundant sea cucumber species in Mediterranean Sea on Egyptian coast. The present study aims to assess anti-oxidative anticholestatic effects of extract (HaE) a model bile duct ligation male albino rats.Fifty four Wistar rats were assigned into two main groups, Sham-operated control ligated (BDL) group. After 14 days surgery, animals group I (Sham control) received distilled water only for 7, 28 days. Second (BDL group) was divided 2 subgroups,...
More research is needed to understand the interactions of nanoparticles (NPs) with aquatic organisms and their mechanism toxic action. Zinc oxide (ZnONPs) are most used engineered metal NPs in consumer products. The present study was designed evaluate cytotoxicity, genotoxicity digestive gland (DG) as well gill histopathology freshwater molluscan bivalve Coelatura aegyptiaca following exposure ZnONPs (2, 10 50 mg/L) for 6 consecutive days. Exposure (10 induced a significant increase...
The current study aimed to evaluate the antibacterial, anti-inflammatory, analgesic, and renoprotective effects of echinochrome pigment extracted from sea urchin. disk diffusion method was used for antibacterial activity against four different bacterial strains; Salmonella typhimurium, Pseudomonas aeroginosa, Staphylococcus aureus, Listeria monocytogenes. While, acetic acid-induced writhing, formalin-induced licking, hot plate latency assays analgesic activity. biochemical oxidative stress...
Abstract Allolobophora calignosa (Ac) is a folk medicine for millennia, as it possesses many biological activities. This study aimed to investigate the chemo-preventive activity of A.calignosa coelomic fluid (AcCF) and extract (AcE) on glucocorticoid-induced osteoporosis (GIOP) in mice. Characterization vitro AcE AcCF has been assessed. Male CD-1 mice were subcutaneously received dexamethasone (DEX) (1 mg/kg, 5 times/week) concurrently intraperitoneally treated with either (20 mg/kg) or (45...
Abstract Main conclusions Green-synthesized zinc oxide nanoparticle is a promising treatment modality against parasitic infection through its powerful anthelmintic, antioxidant, healing promotion, and anti-inflammation effects. Background Nanoparticles have many properties, depending on their size, shape, morphology, allowing them to interact with microorganisms, plants, animals. Objectives Investigation of the therapeutic effects green-synthesized nanoparticles (ZnO NPs) Parascaris equorum...
The present study aims to evaluate the curative activity of freshwater crustacean extract (FCE) from crayfish Procambarus clarkii and silymarin on oxidative stress induced by carbon tetrachloride (CCl4) in rat liver and erythrocytes. degree treatment this has been measured using biochemical parameters such as serum aspartate aminotransferase (ASAT), alanine (ALAT), alkaline phosphatase (ALP) total protein well malondialdehyde (MDA), glutathione reduced (GSH),...
Holothuria arenicola is the most important and abundant sea cucumber species in Mediterranean Sea on Egyptian coast. This work aimed to investigate prophylactic curative effects of H. extract HaE (200 mg/kg) gastric mucosal damage following indomethacin cold stress healthy rats. Sixty-four rats were randomly divided into four main groups. Rats first group (8 rats/group) administered distilled water orally (control group), second single oral dose (150 exposed (4 ± 1 °C) for 30 min induce...
The present study was designed to assess the relationship between anti-schistosomal effect of antimalarial drug mefloquine (Mef) and oxidative stress status Schistosoma mansoni infected mice. Forty mice were divided into eight groups (5 mice/group); control (I, II), (III, IV), Mef low dosage (200 mg/kg) (V, VI), high (400 (VII, VIII). 400 administered orally as a single dose at days 14 35 post infection (PI). All sacrificed after 8 weeks PI. Oral administration or day PI reduced total worm...
Abstract Obesity has been identified with an expanded danger of a progression illnesses that include different organ-frameworks the body. In present examination, we evaluated hypolipidemic properties Echinochrome (Ech) pigment in high-fat diet (HFD) induced hyperlipidemia rats. After hyperlipidemic model was set up, rats were haphazardly separated into five groups as follows: normal control group, HFD Atorvastatin (ATOR) group (80 mg/kg), Ech (1 mg/kg) and combined ATOR + Ech. The outcomes...