A5005339733- Nanoparticle-Based Drug Delivery
- Retinal Diseases and Treatments
- Advancements in Transdermal Drug Delivery
- Curcumin's Biomedical Applications
- RNA Interference and Gene Delivery
- Ocular Surface and Contact Lens
- Lipid Membrane Structure and Behavior
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Advanced Drug Delivery Systems
- Syphilis Diagnosis and Treatment
- Graphene and Nanomaterials Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Dendrimers and Hyperbranched Polymers
- Infectious Diseases and Tuberculosis
- Reproductive System and Pregnancy
- Bone Tissue Engineering Materials
- Ocular Infections and Treatments
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Sarcoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Osteomyelitis and Bone Disorders Research
University of Turin
2019-2025
Background: Solid lipid nanoparticles (SLNs) are attractive drug delivery systems for lipophilic molecules like curcumin (CURC) with low chemical stability. Methods: A simple, innovative, and cold-operating method, named "cold dilution of microemulsion" is developed by the authors to produce SLNs. An oil-in-water microemulsion (µE), whose disperse phase consisted a solution trilaurin in partially water-miscible solvent, was prepared after mutually saturating solvent water. Trilaurin SLNs...
Endophthalmitis is a rare, but serious, intravitreal inflammatory disorder that can arise after cataract surgery. The intracameral injection of 1 mg cefuroxime (CEF) followed by three-times daily antibiotic topical administration for week generally recognized as the routine method prophylaxis This procedure controversial because both low efficacy and adherence to therapy elderly patients. A unique slow release could solve these problems. objective present study was design ophthalmic...
Bevacizumab (BVZ) is a monoclonal antibody that binds to human vascular endothelial growth factor A (VEGF-A) and inhibits the interaction between VEGF-A VEGF receptors, thus blocking angiogenesis. Repeated intravitreal injections of BVZ for treatment ocular pathologies present an excessive proliferation results in low patience compliance. specially indicated diabetic degenerative retinopathy. In study, we designed lipid nanoparticles (NPs) as sustained drug delivery system reducing frequency...
The treatment of bone diseases (including osteoporosis, osteoarthritis, and cancer) often results in reduced efficiency and/or adverse reactions due to the fact that it is not specifically targeted site action. employment a suitable carrier should increase drug location disease. purpose this study prepare characterize lipid nanoparticles (NPs) coated with calcium phosphate (CaP-NPs). A coating method, date used only obtain liposomes covered CaP, herein partially-modified CaP-coated NPs. An...
Osteosarcoma (OSA) is the most frequently diagnosed primary malignant bone tumor in humans and dogs. In both species, standard chemotherapy can be limited by multidrug resistance of neoplastic cells, which prevents intracellular accumulation cytotoxic drugs, resulting failure. this study, a lipophilic ester doxorubicin (C12DOXO) was loaded into nanoparticles (NPs) using "cold microemulsion dilution" method. The NPs were then coated with calcium phosphate (CaP) two different ways to have or...
Bevacizumab (BVZ), a recombinant humanized monoclonal antibody, has recently been proposed as topical application in the treatment of anterior segment neovascularization; however, there are some disadvantages administration common eye-drops, ophthalmic drug delivery systems under study to improve precorneal residence time, reducing frequency administration. In this work, oil-in-water and water-in-oil BVZ-loaded microemulsions developed, able increase their viscosity, either by formation...
Several semisynthetic, low-cardiotoxicity doxorubicin (DOXO) conjugated have been extensively described, considering the risk of cytotoxicity loss against resistant tumor cells, which mainly present drug efflux capacity. Doxorubicin 14-[4-(4-phenyl-5-thioxo-5H-[1,2]dithiol-3-yl)]-benzoate (H2S-DOXO) was synthetized and tested for its ability to overcome resistance with good intracellular accumulation. In this paper, we a formulation study aimed develop naked decorated H2S-DOXO-loaded lipid...
Repeated intravitreal (IVT) injections in the treatment of retinal diseases can lead to severe complications. Developing innovative drug delivery systems for IVT administration is crucial prevent adverse reactions, but requires extensive investigation including use different preclinical models (in vitro, ex vivo and vivo). Our previous work described an vitro tricompartmental ocular flow cell (TOFC) simulating anterior posterior cavities human eye. Based on promising preliminary results,...
Osteosarcoma (OSA) is a bone cancer that affects both humans and animals, with dogs being particularly vulnerable. Standard therapy often limited by multidrug resistance (MDR), primarily due to the overexpression of P-glycoprotein (P-gp), which expels drugs from cells, reducing their efficacy. To overcome this challenge, drug delivery systems (DDS) P-gp modulators have been explored. However, developing DDS selectively target cells remains difficult, many current options lacking efficiency....