A5048033563- Bone Tissue Engineering Materials
- Bacterial biofilms and quorum sensing
- Electrospun Nanofibers in Biomedical Applications
- Antimicrobial Resistance in Staphylococcus
- biodegradable polymer synthesis and properties
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Cell Adhesion Molecules Research
- Streptococcal Infections and Treatments
- Biochemical and Structural Characterization
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Spaceflight effects on biology
- Additive Manufacturing and 3D Printing Technologies
- Orthopedic Infections and Treatments
- Antimicrobial Peptides and Activities
- Bone and Dental Protein Studies
- Titanium Alloys Microstructure and Properties
- Endodontics and Root Canal Treatments
- Nanoplatforms for cancer theranostics
- Nanocomposite Films for Food Packaging
- Antimicrobial agents and applications
- Laser Applications in Dentistry and Medicine
University of Pavia
2016-2025
Istituti Clinici Scientifici Maugeri
2016-2025
Technologies pour la Santé
2017-2025
Institute of Science and Technology for Ceramics
2018-2025
National Research Council
2020-2025
National Interuniversity Consortium of Materials Science and Technology
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2023
ISI Foundation
2020
Fondazione Salvatore Maugeri
2011-2018
Politecnico di Milano
2006-2016
The application of mesoporous bioactive glasses (MBGs) containing controllable amount different ions, with the aim to impart antibacterial activity, as well stimulation osteogenesis and angiogenesis, is attracting an increasing interest. In this contribution, in order endow nano-sized MBG additional biological functions, framework a binary SiO2-CaO glass was modified concentrations copper ions (2 5%mol.), through one-pot ultrasound-assisted sol-gel procedure. Cu-containing (2%mol.) showed...
Macrophage activation can be modulated by biomaterial topography according to the biological scale (micrometric and nanometric range). In this study, we investigated effect of fiber diameter alignment electrospun poly(l-lactic) (PLLA) scaffolds on macrophage RAW 264.7 secretion proinflammatory cytokines chemokines at 24 h 7 days. Macrophages were cultured four different types fibrous PLLA scaffold (aligned microfibers, aligned nanofibers, random nanofibers) film (used as a reference)....
In coatings technology, the possibility of introducing specific characteristics at surface level allows for manufacture medical devices with efficient and prolonged antibacterial properties. This efficiency is often achieved by use a small amount molecules, which can fulfil their duty while limiting eventual releasing problems. The object this work was preparation characterization silver, titanium dioxide chitosan polyurethane-based coatings. Coatings three antibacterials were prepared using...
Twenty-one genes encoding surface proteins belonging to the LPXTG family have been identified by in silico analysis of six Staphylococcus aureus genome sequences. Eleven encode previously described proteins, while 10 not yet characterized. Of these, eight contain cell-wall sorting signal responsible for covalently anchoring peptidoglycan. The remaining two, SasF and SasD, harbour a single residue variation fourth position motif (LPXAG). Western blotting lysostaphin-solubilized S....
Summary Staphylococcus aureus is a leading cause of infective endocarditis (IE). Platelet activation promoted by S. resulting in aggregation and thrombus formation an important step the pathogenesis IE. Here, we report that fibrinogen/fibronectin‐binding proteins FnBPA FnBPB are major platelet‐activating factors on surface from exponential phase growth. Truncated derivatives FnBPA, presenting either fibrinogen‐binding A domain or fibronectin‐binding BCD region, each platelet when expressed...
Staphylococci are important causes of nosocomial and medical-device-related infections. Their virulence is attributed to the elaboration biofilms that protect organisms from immune system clearance increased resistance phagocytosis antibiotics. Photodynamic treatment (PDT) has been proposed as an alternative approach for inactivation bacteria in biofilms. In this study, we have investigated effect photodynamic action toluidine blue O (TBO) on viability structure Staphylococcus epidermidis a...
ABSTRACT The second immunoglobulin-binding protein (Sbi) of Staphylococcus aureus has two N-terminal domains that bind the Fc region IgG in a fashion similar to A and can complement C3 promote its futile consumption fluid phase. It been proposed Sbi helps bacteria avoid innate immune defenses. By comparing mutant defective with mutants A, clumping factor iron-regulated surface determinant H, capsular polysaccharide, it was shown is indeed an evasion promotes bacterial survival whole human...
Abstract Exposure to Pulsed Electromagnetic Field (PEMF) has been shown affect proliferation and differentiation of human mesenchymal stem cells derived from bone marrow stroma (BM-hMSC). These offer considerable promise in the field regenerative medicine, but their clinical application is hampered by major limitations such as poor availability time required differentiate up a stage suitable for implantation. For this reason, several research efforts are focusing on identifying strategies...
Monolayers of gold nanostars (GNS) are grafted on mercaptopropyltrimethoxysilane-coated glass slides. In the formed monolayers localized surface plasmon resonance GNS can be tuned in 700-1100 nm range. Upon laser excitation nearIR LSPR an efficient photothermal response is observed, inducing local hyperthermia and killing Staphylococcus aureus biofilms.
The aim of this study was to evaluate and compare the antimicrobial activity cytocompatibility six different pulp-capping materials: Dycal (Dentsply), Calcicur (Voco), Calcimol LC TheraCal (Bisco), MTA Angelus (Angelus), Biodentine (Septodont). To activity, materials were challenged in vitro with Streptococcus mutans , salivarius sanguis agar disc diffusion test. Cytocompatibility assayed towards rat MDPC-23 cells evaluated at times by both MTT apoptosis assays. Results significantly...