A5044355737- Sarcoidosis and Beryllium Toxicity Research
- Hematopoietic Stem Cell Transplantation
- Cutaneous lymphoproliferative disorders research
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vector-borne infectious diseases
- Wound Healing and Treatments
- Melanoma and MAPK Pathways
- Dermatological and COVID-19 studies
- Mesenchymal stem cell research
- T-cell and B-cell Immunology
- Viral Infections and Vectors
- Biomedical Ethics and Regulation
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Parvovirus B19 Infection Studies
- Nonmelanoma Skin Cancer Studies
- Drug-Induced Adverse Reactions
- Phagocytosis and Immune Regulation
- Infectious Diseases and Mycology
- Dermatology and Skin Diseases
- Single-cell and spatial transcriptomics
- Cutaneous Melanoma Detection and Management
- Extracellular vesicles in disease
Medical University of Vienna
2021-2024
Granulomas are lumps of immune cells that can form in various organs. Most granulomas appear unstructured, yet they have some resemblance to lymphoid To better understand granuloma formation, we performed single-cell sequencing and spatial transcriptomics on from patients with sarcoidosis bioinformatically reconstructed the underlying gene regulatory networks. We discovered an stimulatory environment repurposes transcriptional programs associated organ development. Granuloma formation...
Emigration of tissue-resident memory T cells (TRMs) was recently introduced in mouse models and may drive systemic inflammation. Skin TRMs patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) can coexist beside donor cells, offering a unique human model system to study migration. By genotyping, mathematical modeling, single-cell transcriptomics, functional analysis patient blood skin we detected small consistent population circulating skin-derived with TRM phenotype...
During cutaneous tick attachment, the feeding cavity becomes a site of transmission for salivary compounds and tick-borne pathogens. However, immunological consequences human skin remain unclear. Here, we assessed blood samples upon bite developed explant model mimicking Ixodes ricinus bites pathogen infection. Following observed rapidly occurring patterns immunomodulation, including increases in neutrophils B T cells. cells upregulated tissue residency markers, while lymphocytic cytokine...
Abstract Background Graft-versus-host disease (GvHD) is a major life-threatening complication of allogeneic haematopoietic stem cell transplantation (HSCT), limiting the broad application HSCT for haematological malignancies. Cutaneous GvHD described as post-transplant inflammatory reaction by skin-infiltrating donor T cells and remaining recipient tissue-resident memory cells. Despite influence lymphocytes on pathogenesis, complex role mononuclear phagocytes (MNPs) in tissues affected...
Allogeneic hematopoietic stem-cell transplantation (HSCT) seeks to reconstitute the host's immune system from donor stem cells. The success of HSCT is threatened by complications including leukemia relapse or graft-versus-host-disease (GvHD). To investigate underlying regulatory processes in central and peripheral T cell recovery, we performed sequential multi-omics analysis cells skin blood during HSCT. We detected rapid effector reconstitution, while emergence was delayed. Epigenetic...
In patients infected with severe acute respiratory syndrome coronavirus 2, vasculopathic changes of the skin are associated a prognosis. However, pathogenesis this vasculopathy is not conclusively clarified. study, 25 prospectively collected samples from COVID-19-related lesions were examined for and, in case vasculitis, further analyzed electron microscopy and immunohistochemistry. Vasculopathy was observed 76% all inflammatory lesions. Visual endothelial without manifest leukocytoclastic...
A 55-year-old woman from Afghanistan presented with multiple reddish lesions on the left forearm that appeared 8 weeks prior. Of note, after infiltration of a carpal tunnel syndrome 2 years ago, she had developed recurrent phlegmons forearm. This led to an ulcer which was covered by split skin graft 1.5 ago. The clinical examination showed several livid-erythematous, partially hyperkeratotic plaques, measuring up 3 cm, dorsal (Figure 1). These non-painful plaques expression pus pressure. In...
Abstract Acral melanoma is challenging in two ways: it some cases difficult to diagnose and, once metastases have occurred, the prognosis poor as therapy less effective compared from other parts of skin. Here we report a case, were correct diagnosis was made after has spread already distant sites. Instead surgery, decided start with immunotherapy consisting Ipilimumab and Nivolumab. A complete response could be achieved without surgery any tumors, including primary melanoma.