A5091530860- Advancements in Transdermal Drug Delivery
- Surfactants and Colloidal Systems
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Proteins in Food Systems
- Advanced Drug Delivery Systems
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Skin Protection and Aging
- Lipid Membrane Structure and Behavior
- Wound Healing and Treatments
- Ginseng Biological Effects and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Biological Activity of Diterpenoids and Biflavonoids
- Drug Solubulity and Delivery Systems
- Pain Mechanisms and Treatments
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Ziziphus Jujuba Studies and Applications
- Mast cells and histamine
- Pickering emulsions and particle stabilization
- 3D Printing in Biomedical Research
- Curcumin's Biomedical Applications
- Sesquiterpenes and Asteraceae Studies
- Allergic Rhinitis and Sensitization
University of Vienna
2015-2025
Austrian Centre for Electron Microscopy and Nanoanalysis
2014
Graz University of Technology
2014
Abstract Background The rheological properties of dermal drug delivery systems are importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the penetration incorporated actives. Data on latter aspect controversial. Our objective was to elucidate relation between viscosity performance different model hydrogels assuming that enhanced microviscosity might delay release penetration. Materials Methods Hydrogels...
Skin is the largest organ and a multifunctional interface between body its environment. It acts as barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, it also known mirror of soul. The skin involved in temperature regulation by storage fat water. an interesting tissue regard to local transdermal application active ingredients for prevention treatment pathological conditions. Topical delivery emerging route drug cosmetic administration....
Postoperative pain affects most patients after major surgery and can transition to chronic pain. The considerable side effects limited efficacy of current treatments underline the need for new therapeutic options. We observed increased amounts metabolites BH4 serotonin skin injury. Mast cells were primary postoperative sources Gch1 , rate-limiting enzyme in synthesis, itself an obligate cofactor production by tryptophan hydroxylase (Tph1). Mice deficient mast or cell–specific Tph1 showed...
Phospholipids are versatile formulation compounds with high biocompatibility. However, no data on their effect skin in combination UVA radiation exist. Thus, it was the aim of this work to (i) develop o/w nanoemulsions (NEs) differing surfactant type and investigate physicochemical stability at different storage temperatures, (ii) establish a standardized protocol for vitro phototoxicity testing using primary human cells (iii) amphoteric phospholipids (S45, S75, E80, S100, LPC80), sodium...
In previous studies, lecithin-based nanoemulsions (NEs) have been shown to be skin friendly drug carrier systems. Due their nontoxic properties, NEs might also suitable as wound healing agents. Hence, different O/W based on lecithin Lipoid® S 75 and plant oils or medium chain triglycerides were produced characterised. Two lipophilic natural agents, a betulin-enriched extract from birch bark (BET) purified spruce balm (PSB), successfully incorporated effects primary human cells studied in...
Infrared (IR) densitometry is a highly practical method recently proposed for protein analysis during in vivo tape stripping. However, this has not yet been validated the quantification of porcine stratum corneum (SC) proteins. Therefore, aim study was to establish calibration curves adhesive tapes removed from ear skin. To end, absorption (as determined via IR densitometry) correlated with content Micro BCA™ assay after extraction tapes. The obtained linear regressions confirm that suitable...
Mild non-ionic sucrose ester surfactants can be employed to produce lipid-based drug delivery systems for dermal application. Moreover, esters of intermediate lipophilicity such as stearate S-970 possess a peculiar rheological behavior which create highly viscous semi-solid formulations without any further additives. Interestingly, it was possible develop both macroemulsions and fluid nanoemulsions with the same chemical composition merely by slight alteration production process. Optical...
Excised animal and human skins are frequently used in permeability testing pharmaceutical research. Several factors exist that may have influence on the results. In current study some of skin parameters affect drug were analysed for human, mouse, rat pig skin.Classic biophysical measured (e.g. pH, hydration, permittivity, transepidermal water loss). Physiological characteristics also by confocal Raman spectroscopy, scanning electron microscopy two-photon microscopy.Based testing, barrier...
Although very common in our society, the effect of hair removal on physiological skin parameters and ingress applied chemicals has not been systematically investigated. Thus, as a first step, aim present study was to elucidate through epilation (electric epilation, waxing) depilation (dry wet shaving, depilatory cream) properties vitro using porcine ear model.Attenuated total reflection Fourier transform infrared spectroscopy, measurement transepidermal water loss (TEWL), visualization by...
(1) Background: The aim of the study was to evaluate effect pure lecithins in comparison a conventional surfactant on skin vivo. (2) Methods: Physiological parameters were evaluated at beginning and end (day 1 day 4) (n = 8, healthy forearm skin) with an Aquaflux®, skin-pH-Meter, Corneometer® Epsilon® sensor. Confocal Raman spectroscopy employed monitor natural moisturizing factor, urea water content participants’ skin. Tape strips treated sites taken collected corneocytes subjected atomic...