A5079506605- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Vitamin D Research Studies
- Neonatal Health and Biochemistry
- SARS-CoV-2 and COVID-19 Research
- Heme Oxygenase-1 and Carbon Monoxide
- Ovarian function and disorders
- Parathyroid Disorders and Treatments
- SARS-CoV-2 detection and testing
- Adipose Tissue and Metabolism
- Reproductive Biology and Fertility
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
- Bariatric Surgery and Outcomes
- Thyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Bone health and osteoporosis research
- Dialysis and Renal Disease Management
- Magnesium in Health and Disease
- Atherosclerosis and Cardiovascular Diseases
- Pituitary Gland Disorders and Treatments
Medical University of Vienna
2016-2025
Vienna General Hospital
2011-2021
University of Vienna
2001-2018
Zentrum für Labormedizin
2015
National Heart Foundation of Australia
2013
University of Copenhagen
2013
Bispebjerg Hospital
2013
Griffith University
2013
Rigshospitalet
2013
Ludwig Boltzmann Institute Applied Diagnostics
2012
Reliable quantification of the antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly relevant, e.g., for identifying possible vaccine failure and estimating time protection. Therefore, we evaluated five different anti-SARS-CoV-2 assays regarding anti-spike (S) antibodies. Sera from 69 SARS-CoV-2-naive individuals 21 ± 1 days after vaccination with a single dose BNT162b2 (Pfizer/BioNTech) were tested using following quantitative assays: Roche S total...
Sclerostin serum levels are increased in patients with chronic kidney disease (CKD). Osteoporosis and CKD often occur simultaneously. Currently antisclerostin antibodies clinical development for the treatment of osteoporosis.The objective this study was to renal handling sclerostin.This a cross-sectional study.The conducted at university hospital outpatient clinic.One hundred twenty men women stage 1-5 participated study.Measurements sclerostin urine (ELISA), function [estimated glomerular...
Abstract Background In the context of COVID-19 pandemic, numerous new serological test systems for detection anti-SARS-CoV-2 antibodies rapidly have become available. However, clinical performance many these is still insufficiently described. Therefore, we compared 3 commercial CE-marked, SARS-CoV-2 antibody assays side by side. Methods We included a total 1154 specimens from pre-COVID-19 times and 65 samples patients (≥14 days after symptom onset) to evaluate Abbott, Roche, DiaSorin....
Experimental data suggest that bacterial translocation (BT) promotes systemic inflammation, portal hypertension, and circulatory dysfunction in advanced chronic liver disease (ACLD).Patients with ACLD undergoing hepatic venous pressure gradient (HVPG) measurement absence of acute decompensation or infections were included (n = 249). Serum biomarkers BT (lipopolysaccharide [LPS], lipoteichoic acid [LTA], DNA [bactDNA]), inflammation markers assessed. T-cell subsets intestinal biopsies 7 ACLD,...
Chronic myeloid leukemia (CML) is a stem cell disease in which BCR/ABL promotes the survival of leukemic cells. Heme oxygenase-1 (HO-1) an inducible stress protein that catalyzes degradation heme and has recently been implicated regulation growth various neoplastic In present study, we analyzed expression role HO-1 CML As assessed by Northern Western blot analysis as well immunostaining, primary cells were found to express mRNA constitutive manner. Exposure these tyrosine kinase inhibitor...
Most lymphoid malignancies are initiated by specific chromosomal translocations between immunoglobulin (Ig)/T cell receptor (TCR) gene segments and cellular proto-oncogenes. In many cases, illegitimate V(D)J recombination has been proposed to be involved in the translocation process, but this never functionally established. Using extra-chromosomal assays, we determined ability of several proto-oncogenes target recombination, assessed impact their recombinogenic potential on rates vivo. Our...
Recent epidemiological and clinical data show protection from CVD (cardiovascular disease), all-cause mortality cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only part to this protection. Therefore we investigated whether circulating UCB (unconjugated bilirubin) associated altered lipid metabolism. study was performed on age- gender-matched...
Background In nonalcoholic fatty liver disease (NAFLD), advanced fibrosis has been identified as an important prognostic factor with increased liver‐related mortality and treatment need. Due to the high prevalence of NAFLD, noninvasive risk stratification is needed select patients for biopsy treatment. Objective To compare diagnostic accuracy several widely available tests assessment among NAFLD or without steatohepatitis (NASH). Methods We enrolled consecutive admitted two Austrian referral...
The SARS-CoV-2 Omicron variant is characterized by substantial changes in the antigenic structure of Spike (S) protein. Therefore, antibodies induced primary infection lack neutralizing activity against earlier variants. In this study, we analyzed whether these impact sensitivity commercial anti-SARS-CoV-2 antibody assays. Sera from 37 unvaccinated, convalescent individuals after putative were tested with a panel 20 immunoassays. As controls, used samples 43 ancestral wild-type strain....
•Complement factors, immunoglobulins, and acute-phase proteins are dysregulated in patients with advanced chronic liver disease (ACLD), correlate severity, indicate alterations of innate adaptive immunity.•Low complement C3c levels independently predicted decompensation or liver-related death ACLD.•High IgG-1 the incidence infections ACLD. Background & AimsCirrhosis-associated immune dysfunction (CAID) affects both immunity. This study investigated system, their prognostic relevance...
Abstract Background and aims Experimental studies linked dysfunctional Farnesoid X receptor (FXR)-fibroblast growth factor 19 (FGF19) signaling to liver disease. This study investigated key intersections of the FXR-FGF19 pathway along gut–liver axis their link disease severity in patients with cirrhosis. Methods Patients cirrhosis undergoing hepatic venous pressure gradient measurement (cohort-I n = 107, including 53 concomitant biopsy; 5 healthy controls) or colonoscopy ileum biopsy...
AimsPrevious risk assessment scores for patients with coronary artery disease (CAD) have focused on primary prevention and acute syndrome. However, especially in stable CAD improved long-term prediction is crucial to efficiently apply measures of secondary prevention. We aimed create a clinically applicable mortality score based routinely determined laboratory biomarkers clinical determinants
<h3>Objective</h3> Biomarkers play a pivotal role in heart failure (HF) management. Reference values and insights from studies adults cannot be extrapolated to the paediatric population due important differences pathophysiology compensatory reserve. We assessed diagnostic utility of four novel biomarkers HF. <h3>Methods</h3> Midregional (MR) pro-atrial natriuretic peptide (proANP), soluble ST2 (sST2), growth differentiation factor-15 (GDF-15), MR-pro-adrenomedullin (proADM) N-terminal pro-B...
Scope Oxidative imbalance plays a key role in cancer induction and cardiovascular diseases (CVD) patients with type 2 diabetes mellitus (T2DM). The aim of this study is to find out if gallic acid (GA) prevents oxidative stress diabetic patients. Therefore, we investigate its impact on oxidation DNA bases other health‐related macromolecules. Methods results We perform an intervention ( n = 19) GA monitored alterations the stability single cell gel electrophoresis (SCGE) assays lymphocytes....
<b><i>Background:</i></b> Fragility fractures, especially hip are a very common complication of osteoporosis in elderly subjects. Sclerostin (SOST) and dickkopf-1 (DKK-1) inhibitors the canonical wnt signalling pathway thus could be involved pathogenesis age-related bone fragility. <b><i>Objective:</i></b> To investigate SOST DKK-1 large group geriatric patients with fractures to relate age gender. <b><i>Methods:</i></b>...
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Obesity is associated with increasing cardiometabolic morbidity and mortality worldwide. Not everyone obesity, however, develops metabolic complications. Brown adipose tissue (BAT) has been suggested as a promoter of leanness health. To date, little known about the prevalence function BAT in subjects severe population at high risk. In this cross-sectional study, we included 40 individuals WHO class II-III obesity (BMI ≥ 35 kg/m2). Employing 150-minute personalized cooling protocol...
Abstract Background & Aims Experimental evidence indicates that systemic inflammation (SI) promotes liver fibrogenesis. This study investigated the potential link between SI and fibrogenesis in patients with advanced chronic disease (ACLD). Methods Serum biomarkers of (CRP, IL‐6, procalcitonin [PCT]) extracellular matrix (ECM) turnover (i.e., fibrogenesis/fibrolysis) were analysed 215 prospectively recruited ACLD (hepatic venous pressure gradient [HVPG] ≥6 mm Hg) undergoing hepatic vein...
Due to its high metabolic activity, brown adipose tissue (BAT) has become a promising target for the development of novel treatment concepts disease. Despite several reports negative association between presence active BAT and obesity, very little is known about quantitative qualitative differences in lean obese individuals. Systematic studies directly comparing cold-induced activity leanness obesity are currently lacking. Here we studied mass function 31 64 men women. After standardized...
Abstract We aimed to assess the systemic and hepatic renin-angiotensin-system (RAS) fingerprint in advanced chronic liver disease (ACLD). This prospective study included 13 compensated (cACLD) 12 decompensated ACLD (dACLD) patients undergoing venous pressure gradient (HVPG) measurement. Plasma components (all patients) liver-local enzymes (n = 5) of RAS were analyzed using liquid chromatography–tandem mass spectrometry. Patients with dACLD had significantly higher angiotensin (Ang) I, Ang II...
Background: In functional hypothalamic amenorrhea (FHA), luteinizing hormone and follicle-stimulating levels show high interindividual variability, which significantly limits their diagnostic value in differentiating FHA from polycystic ovary syndrome (PCOS). Our aim was to profile the LH:FSH ratio a large sample of patients with well-defined FHA. Methods: This observational study included all consecutive presenting Department Gynecologic Endocrinology Reproductive Medicine, Medical...