A5068360894- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Cytomegalovirus and herpesvirus research
- Liver Diseases and Immunity
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- Polyomavirus and related diseases
- Biosensors and Analytical Detection
- Liver Disease and Transplantation
- Infection Control and Ventilation
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- COVID-19 and healthcare impacts
- Renal Transplantation Outcomes and Treatments
- Parvovirus B19 Infection Studies
- Infrared Thermography in Medicine
- HIV/AIDS drug development and treatment
- COVID-19 epidemiological studies
Medical University of Vienna
2016-2025
Vienna General Hospital
2021
University of Veterinary Medicine Vienna
2015
Austrian Breast & Colorectal Cancer Study Group
2014
University Gastroenterology
2013
Dayanand Medical College & Hospital
2013
Paracelsus Medizinische Privatuniversität
2009
Universitätsklinik für Chirurgie Wien
1972
Fewer than 50% of kidney transplant recipients (KTRs) develop antibodies against the SARS-CoV-2 spike protein after 2 doses an mRNA vaccine. Preliminary data suggest that a heterologous vaccination, combining and viral vector vaccines, may increase immunogenicity.To assess effectiveness third dose vs vaccine in KTRs who did not have vaccine.This was single center, single-blinded, 1:1 randomized clinical trial SARS-CoV-2, conducted from June 15 to August 16, 2021, 201 had developed Data...
Abstract Background In the context of COVID-19 pandemic, numerous new serological test systems for detection anti-SARS-CoV-2 antibodies rapidly have become available. However, clinical performance many these is still insufficiently described. Therefore, we compared 3 commercial CE-marked, SARS-CoV-2 antibody assays side by side. Methods We included a total 1154 specimens from pre-COVID-19 times and 65 samples patients (≥14 days after symptom onset) to evaluate Abbott, Roche, DiaSorin....
Drug-induced immunosuppression following kidney transplantation is crucial to prevent allograft rejection, but increases risk for infectious disease. Tailoring of drug dosing both rejection and infection greatly desirable. The apathogenic ubiquitous torque teno virus (TTV) reflects immunocompetence the host might be a potential candidate immunologic monitoring. To assess TTV as an biomarker, load was prospectively quantified in peripheral blood 169 consecutive renal recipients at Medical...
The nonpathogenic and ubiquitous torque teno virus (TTV) is associated with immunosuppression in solid organ transplant recipients. Studies kidney patients proposed TTV quantification for risk stratification of graft rejection infection. In this prospective trial (DRKS00012335) 386 consecutive recipients were subjected to longitudinal per-protocol monitoring plasma load by polymerase chain reaction 12 months posttransplant. peaked at the end month 3 posttransplant reached steady state...
Coronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.This case-control study compared brachial-ankle pulse wave (baPWV) and carotid-femoral velocities (cfPWV) of acutely ill patients without COVID-19.Twenty-two (50% females, 77 [67-84] years) were 22 age- sex-matched controls. In patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], P = 0.02) cfPWV (14.3 [13.4-16.0] 11.0 [9.5-14.6], 0.01)...
The objective of our study was to evaluate the sensitivity and specificity rapid antigen detection tests versus those reverse transcriptase PCR (RT-PCR) using oral, anterior nasal, nasopharyngeal swabs. underlying prospective, diagnostic case-control-type accuracy included 87 hospitalized nonhospitalized participants in a positive negative sample cohort between 16 March 14 May 2021 two hospitals Vienna. SARS-CoV-2 infection status confirmed by RT-PCR. Participants self-performed one oral...
Abstract Background and Aims Cholestasis is associated with disease severity worse outcome in COVID‐19. Cases of secondary sclerosing cholangitis (SSC) after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection have been described. Approach Results Hospitalized patients COVID‐19 between 03/2020 07/2021 were included. Patients stratified as having (i) no chronic liver (CLD), (ii) non‐advanced CLD (non‐ACLD), or (iii) advanced (ACLD). non–COVID‐19 pneumonia matched to a...
To our knowledge, little is known about antibody development after SARS-CoV-2 vaccination in immunocompromised individuals, such as patients with cancer.To determine whether hematooncological develop anti-SARS-CoV-2 antibodies vaccination.This retrospective cohort study included 2 independent cohorts of who were treated for hematological and solid malignant tumors between October 2020 May 2021, comprising 901 samples from 595 58 health care workers (HCWs). Serum collected at an academic...
Torque Teno virus (TTV) is nonpathogenic, highly prevalent, and reflects the immune status of its host. Thus, TTV plasma load was suggested for guidance immunosuppression post solid organ transplantation. The present study designed to determine kinetics following changes in calcineurin inhibitor (CNI) dose. A total 48 adult recipients a kidney graft transplanted at Medical University Vienna between 2018 2019 with isolated CNI dose were selected from prospective TTV-POET trial. quantified by...
Drug-induced immunosuppression in kidney transplant recipients is crucial to prevent allograft rejection, but increases risk for infectious disease. Immunologic monitoring tailor immunosuppressive drugs might alloreactivity and adverse effects simultaneously. The apathogenic torque teno virus (TTV) reflects the immunocompetence of its host act as a potential candidate holistic monitoring. We screened all 1010 consecutive patients from prospective Vienna Kidney Transplant Cohort Study...
Nonpathogenic torque teno viruses (TTVs) are highly prevalent in transplant recipients and associated with immunosuppression. Studies kidney patients have proposed assessment of TTV load for risk stratification clinically overt graft rejection. The value quantification the context subclinical rejection has not been evaluated.In this prospective trial, 307 consecutive were subjected to per-protocol monitoring plasma TTV. was analyzed protocol biopsies (n = 82), scheduled 1 year...
Summary Background In recent years there has been an increase in the diagnoses of sexually transmitted infections (STI) among men who have sex with (MSM) using human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP); however, data on PrEP users Austria are limited. Patients, material and methods June 2020, we initiated a prospective observational cohort study at Vienna General Hospital including from Vienna. Participants underwent STI testing quarterly provided behavioral...
Summary. Data on the efficacy of lamivudine (LAM)‐, tenofovir (TDF)‐ and emtricitabine (FTC)‐based antiretroviral therapy (HAART) in HBV–HIV coinfection are limited. We completed a retrospective analysis HBV–HIV‐coinfected patients treated at Medical University Vienna. One‐hundred ten coinfected were included, with 57% being initially HBV e‐Antigen (HBeAg) positive. Baseline load was significantly higher HBeAg+ than HBeAg− (5962 ± 3663 vs 20 19 × 10 6 IU/mL; P < 0.0001). Over median...
To analyze the prevalence of SARS-CoV-2 infection in patients with cancer hospital care after implementation institutional and governmental safety measurements.
BackgroundDuring the COVID-19 outbreak, healthcare professionals (HCP) are at frontline of clinical management and increased risk for infection. The SARS-CoV-2 seroprevalence oncological HCP their patients has significant implications care.MethodsHCP with cancer Division Oncology, Medical University Vienna were included between 21 March 4 June tested total antibodies against employing Roche Elecsys Anti-SARS-CoV-2 immunoassay. Reactive samples confirmed or disproved by Abbott IgG test....
Antibody tests are essential tools to investigate humoral immunity following SARS-CoV-2 infection or vaccination. While first-generation antibody have primarily provided qualitative results, accurate seroprevalence studies and tracking of levels over time require highly specific, sensitive quantitative test setups.
SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound of the "alternative" (alt) renin-angiotensin system (RAS). ACE2 counteracts angiotensin II by converting it to potentially protective 1-7. Using mass spectrometry, we assessed key metabolites classical RAS (angiotensins I-II) and alt-RAS 1-7 1-5) pathways as well ACE concentrations in 159 patients hospitalized with COVID-19, stratified disease severity (severe, n = 76; non-severe: 83). Plasma renin...
Hemophagocytic lymphohistiocytosis (HLH) is an excessive immune activation with cytokine storm und multi-organ dysfunction. It can occur secondarily, especially due to viral infections like COVID-19. Rapid treatment crucial for favourable outcomes, but diagnosing HLH challenging. The most common diagnostic instrument the H-Score. However, prognostic value of H-score has not yet been assessed in detail spotlight secondary severe COVID-19 patients treated between February 2020 and April 2021...
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing disease 2019 (COVID-19) can damage the endothelium and increase arterial stiffness, potentially leading to adverse cardiovascular events. In parallel, systemic inflammation in COVID-19 also impacts endothelial function. Angiotensin-converting enzyme (ACE2) promotes vasodilation anti-inflammatory effects, but facilitates SARS-CoV-2 entry into human cells. Thus, concerns have been raised about use of RAAS...